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Article: Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK

TitlePolysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK
Authors
Issue Date2014
Citation
BMC Complementary and Alternative Medicine, 2014, v. 14, p. 303 How to Cite?
AbstractBACKGROUND: Prostate cancer (PCa) frequently relapses after hormone ablation therapy. Unfortunately, once progressed to the castration resistant stage, the disease is regarded as incurable as prostate cancer cells are highly resistant to conventional chemotherapy. METHOD: We recently reported that the two natural compounds polysaccharopeptide (PSP) and Gamma-tocotrienols (gamma-T3) possessed potent anti-cancer activities through targeting of CSCs. In the present study, using both prostate cancer cell line and xenograft models, we seek to investigate the therapeutic potential of combining gamma-T3 and PSP in the treatment of prostate cancer. RESULT: We showed that in the presence of PSP, gamma-T3 treatment induce a drastic activation of AMP-activated protein kinase (AMPK). This was accompanied with inactivation of acetyl-CoA carboxylase (ACC), as evidenced by the increased phosphorylation levels at Ser 79. In addition, PSP treatment also sensitized cancer cells toward gamma-T3-induced cytotoxicity. Furthermore, we demonstrated for the first time that combination of PSP and gamma-T3 treaments significantly reduced the growth of prostate tumor in vivo. CONCLUSION: Our results indicate that PSP and gamma-T3 treaments may have synergistic anti-cancer effect in vitro and in vivo, which warrants further investigation as a potential combination therapy for the treatment of cancer.
Persistent Identifierhttp://hdl.handle.net/10722/219202
ISSN
2015 Impact Factor: 1.987
2015 SCImago Journal Rankings: 0.783

 

DC FieldValueLanguage
dc.contributor.authorLiu, J-
dc.contributor.authorLau, YT-
dc.contributor.authorChen, J-
dc.contributor.authorYong, J-
dc.contributor.authorTang, KD-
dc.contributor.authorLo, J-
dc.contributor.authorNg, IOL-
dc.contributor.authorLee, KW-
dc.contributor.authorLing, MT-
dc.date.accessioned2015-09-18T07:17:23Z-
dc.date.available2015-09-18T07:17:23Z-
dc.date.issued2014-
dc.identifier.citationBMC Complementary and Alternative Medicine, 2014, v. 14, p. 303-
dc.identifier.issn1472-6882-
dc.identifier.urihttp://hdl.handle.net/10722/219202-
dc.description.abstractBACKGROUND: Prostate cancer (PCa) frequently relapses after hormone ablation therapy. Unfortunately, once progressed to the castration resistant stage, the disease is regarded as incurable as prostate cancer cells are highly resistant to conventional chemotherapy. METHOD: We recently reported that the two natural compounds polysaccharopeptide (PSP) and Gamma-tocotrienols (gamma-T3) possessed potent anti-cancer activities through targeting of CSCs. In the present study, using both prostate cancer cell line and xenograft models, we seek to investigate the therapeutic potential of combining gamma-T3 and PSP in the treatment of prostate cancer. RESULT: We showed that in the presence of PSP, gamma-T3 treatment induce a drastic activation of AMP-activated protein kinase (AMPK). This was accompanied with inactivation of acetyl-CoA carboxylase (ACC), as evidenced by the increased phosphorylation levels at Ser 79. In addition, PSP treatment also sensitized cancer cells toward gamma-T3-induced cytotoxicity. Furthermore, we demonstrated for the first time that combination of PSP and gamma-T3 treaments significantly reduced the growth of prostate tumor in vivo. CONCLUSION: Our results indicate that PSP and gamma-T3 treaments may have synergistic anti-cancer effect in vitro and in vivo, which warrants further investigation as a potential combination therapy for the treatment of cancer.-
dc.languageeng-
dc.relation.ispartofBMC Complementary and Alternative Medicine-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titlePolysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK-
dc.typeArticle-
dc.identifier.emailLau, YT: eytlau@hku.hk-
dc.identifier.emailLo, J: jlo88@hku.hk-
dc.identifier.emailNg, IOL: iolng@hku.hk-
dc.identifier.emailLee, KW: tkwlee@hkucc.hku.hk-
dc.identifier.authorityNg, IOL=rp00335-
dc.identifier.authorityLee, KW=rp00447-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1472-6882-14-303-
dc.identifier.hkuros252155-
dc.identifier.volume14-
dc.identifier.spage303-
dc.identifier.epage303-

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