File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Altered myocardial response in patients with diabetic retinopathy: An exercise echocardiography study

TitleAltered myocardial response in patients with diabetic retinopathy: An exercise echocardiography study
Authors
Issue Date2015
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cardiab.com/
Citation
Cardiovascular Diabetology, 2015, v. 14, article no. 123 How to Cite?
AbstractType 2 diabetes mellitus (T2DM) complicated by retinopathy is associated with altered left ventricular (LV) structure and resting myocardial dysfunction unlike T2DM without retinopathy. The myocardial response to stress has not been compared in patients with and without diabetic retinopathy. The aim of this retrospective study was to determine the relationship between retinopathy and myocardial function in patients with T2DM at rest and during exercise echocardiography. Methods 134 patients with T2DM and no evidence of underlying coronary artery disease were recruited. All patients underwent retinal photography to screen for diabetic retinopathy, and resting and exercise echocardiography. Resting echocardiography was analyzed by conventional echocardiographic parameters and speckle tracking derived global longitudinal strain (GLS). Exercise echocardiography parameters included diastolic function reserve index (DFRI) and stress GLS. Results The mean age of participants was 60 years and 49% were male. Diabetic retinopathy was identified in 43 patients (32%). Resting echocardiography revealed that those with diabetic retinopathy had a higher prevalence of impaired diastolic function, higher E/E` ratio (LV filling pressures) and impaired resting GLS compared with those without. Exercise echocardiography revealed that those with diabetic retinopathy also had more impaired DFRI and stress GLS. Multivariable analysis showed that the presence of diabetic retinopathy was independently associated with high resting E/E`, diastolic dysfunction grade, impaired resting GLS, low DFRI and impaired stress GLS. Conclusions In conclusion, the presence of diabetic retinopathy was independently associated with impaired resting myocardial function (diastolic and systolic function) and myocardial function during stress (evaluated by DFRI and stress GLS).
Persistent Identifierhttp://hdl.handle.net/10722/219168
ISSN
2015 Impact Factor: 4.534
2015 SCImago Journal Rankings: 1.757
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhen, Z-
dc.contributor.authorChen, Y-
dc.contributor.authorShih, KC-
dc.contributor.authorLiu, JH-
dc.contributor.authorYuen, MAM-
dc.contributor.authorWong, DSH-
dc.contributor.authorLam, KSL-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.date.accessioned2015-09-18T07:15:41Z-
dc.date.available2015-09-18T07:15:41Z-
dc.date.issued2015-
dc.identifier.citationCardiovascular Diabetology, 2015, v. 14, article no. 123-
dc.identifier.issn1475-2840-
dc.identifier.urihttp://hdl.handle.net/10722/219168-
dc.description.abstractType 2 diabetes mellitus (T2DM) complicated by retinopathy is associated with altered left ventricular (LV) structure and resting myocardial dysfunction unlike T2DM without retinopathy. The myocardial response to stress has not been compared in patients with and without diabetic retinopathy. The aim of this retrospective study was to determine the relationship between retinopathy and myocardial function in patients with T2DM at rest and during exercise echocardiography. Methods 134 patients with T2DM and no evidence of underlying coronary artery disease were recruited. All patients underwent retinal photography to screen for diabetic retinopathy, and resting and exercise echocardiography. Resting echocardiography was analyzed by conventional echocardiographic parameters and speckle tracking derived global longitudinal strain (GLS). Exercise echocardiography parameters included diastolic function reserve index (DFRI) and stress GLS. Results The mean age of participants was 60 years and 49% were male. Diabetic retinopathy was identified in 43 patients (32%). Resting echocardiography revealed that those with diabetic retinopathy had a higher prevalence of impaired diastolic function, higher E/E` ratio (LV filling pressures) and impaired resting GLS compared with those without. Exercise echocardiography revealed that those with diabetic retinopathy also had more impaired DFRI and stress GLS. Multivariable analysis showed that the presence of diabetic retinopathy was independently associated with high resting E/E`, diastolic dysfunction grade, impaired resting GLS, low DFRI and impaired stress GLS. Conclusions In conclusion, the presence of diabetic retinopathy was independently associated with impaired resting myocardial function (diastolic and systolic function) and myocardial function during stress (evaluated by DFRI and stress GLS).-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cardiab.com/-
dc.relation.ispartofCardiovascular Diabetology-
dc.rightsCardiovascular Diabetology. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAltered myocardial response in patients with diabetic retinopathy: An exercise echocardiography study-
dc.typeArticle-
dc.identifier.emailShih, KC: kcshih@hku.hk-
dc.identifier.emailLiu, JH: liujuhua@hku.hk-
dc.identifier.emailWong, DSH: shdwong@hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityShih, KC=rp01374-
dc.identifier.authorityWong, DSH=rp00516-
dc.identifier.authorityLam, KSL=rp00343-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12933-015-0281-5-
dc.identifier.pmid26382215-
dc.identifier.pmcidPMC4574544-
dc.identifier.scopuseid_2-s2.0-84942014735-
dc.identifier.hkuros252031-
dc.identifier.volume14-
dc.identifier.isiWOS:000361357300001-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats