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Article: The Effects of Macrophage Polarity on Influenza Virus Replication and Innate Immune Responses

TitleThe Effects of Macrophage Polarity on Influenza Virus Replication and Innate Immune Responses
Authors
Issue Date2015
Citation
Journal of Clinical & Cellular Immunology, 2015, v. 6, p. 297 How to Cite?
AbstractDifferent pathways of macrophage differentiation and activation lead to diverse macrophage phenotypes including expression of cell surface molecules, cytokine secretion and transcription profiles. Here we investigated in vitro the impact of inflammatory or anti-inflammatory polarization of human primary macrophages on their susceptibility to Influenza A virus infection and characterised innate immune responses in infected cells. M2 M-CSF+IL4 macrophages showed greater susceptibility to influenza A infection than M1 GM-CSF+interferon (IFN)γ macrophages.
Persistent Identifierhttp://hdl.handle.net/10722/219149

 

DC FieldValueLanguage
dc.contributor.authorDUTRY, ICA-
dc.contributor.authorLi, J-
dc.contributor.authorLi, PH-
dc.contributor.authorBruzzone, R-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorJaume, MDA-
dc.date.accessioned2015-09-18T07:14:46Z-
dc.date.available2015-09-18T07:14:46Z-
dc.date.issued2015-
dc.identifier.citationJournal of Clinical & Cellular Immunology, 2015, v. 6, p. 297-
dc.identifier.urihttp://hdl.handle.net/10722/219149-
dc.description.abstractDifferent pathways of macrophage differentiation and activation lead to diverse macrophage phenotypes including expression of cell surface molecules, cytokine secretion and transcription profiles. Here we investigated in vitro the impact of inflammatory or anti-inflammatory polarization of human primary macrophages on their susceptibility to Influenza A virus infection and characterised innate immune responses in infected cells. M2 M-CSF+IL4 macrophages showed greater susceptibility to influenza A infection than M1 GM-CSF+interferon (IFN)γ macrophages.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical & Cellular Immunology-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleThe Effects of Macrophage Polarity on Influenza Virus Replication and Innate Immune Responses-
dc.typeArticle-
dc.identifier.emailLi, PH: phli@hkucc.hku.hk-
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailJaume, MDA: breizh@hku.hk-
dc.identifier.authorityBruzzone, R=rp01442-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.4172/2155-9899.1000297-
dc.identifier.hkuros252401-
dc.identifier.volume6-
dc.identifier.spage297-
dc.identifier.epage297-

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