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Article: Hypromellose-graft-chitosan and Its Polyelectrolyte Complex as Novel Systems for Sustained Drug Delivery

TitleHypromellose-graft-chitosan and Its Polyelectrolyte Complex as Novel Systems for Sustained Drug Delivery
Authors
Issue Date2015
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick
Citation
ACS Applied Materials & Interfaces, 2015, v. 7 n. 19, p. 10501-10510 How to Cite?
AbstractPolyelectrolyte complexes formed between chitosan (CS) and anionic polymers have attracted increasing interest in drug delivery. In this study, CS is copolymerized with hypromellose via a coupling reagent-mediated approach to form a water-soluble, nontoxic CS derivative, namely hypromellose-graft-CS (HC), which is subsequently complexed with carboxymethylcellulose (CMC) to generate a polyampholytic hydrogel. When compared with conventional CS, HC is highly water-soluble across a wide pH range, and has a substantially higher pH buffering capacity to provide a pH-stable environment for delivery of drugs. In addition, the polyelectrolyte complex of HC exhibits a drug encapsulation efficiency of over 90% in all drugs tested, which is 1–2 fold higher than the efficiency attainable by the polyelectrolyte complex of conventional CS, with a 2–3 fold longer duration of sustained drug release. Our results indicate that as a novel polymer, HC has excellent promise for future pharmaceutical applications.
Persistent Identifierhttp://hdl.handle.net/10722/219124
ISSN
2015 Impact Factor: 7.145
2015 SCImago Journal Rankings: 2.381

 

DC FieldValueLanguage
dc.contributor.authorLai, WF-
dc.contributor.authorShum, HC-
dc.date.accessioned2015-09-18T07:13:47Z-
dc.date.available2015-09-18T07:13:47Z-
dc.date.issued2015-
dc.identifier.citationACS Applied Materials & Interfaces, 2015, v. 7 n. 19, p. 10501-10510-
dc.identifier.issn1944-8244-
dc.identifier.urihttp://hdl.handle.net/10722/219124-
dc.description.abstractPolyelectrolyte complexes formed between chitosan (CS) and anionic polymers have attracted increasing interest in drug delivery. In this study, CS is copolymerized with hypromellose via a coupling reagent-mediated approach to form a water-soluble, nontoxic CS derivative, namely hypromellose-graft-CS (HC), which is subsequently complexed with carboxymethylcellulose (CMC) to generate a polyampholytic hydrogel. When compared with conventional CS, HC is highly water-soluble across a wide pH range, and has a substantially higher pH buffering capacity to provide a pH-stable environment for delivery of drugs. In addition, the polyelectrolyte complex of HC exhibits a drug encapsulation efficiency of over 90% in all drugs tested, which is 1–2 fold higher than the efficiency attainable by the polyelectrolyte complex of conventional CS, with a 2–3 fold longer duration of sustained drug release. Our results indicate that as a novel polymer, HC has excellent promise for future pharmaceutical applications.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick-
dc.relation.ispartofACS Applied Materials & Interfaces-
dc.titleHypromellose-graft-chitosan and Its Polyelectrolyte Complex as Novel Systems for Sustained Drug Delivery-
dc.typeArticle-
dc.identifier.emailLai, WF: wflai@hku.hk-
dc.identifier.emailShum, HC: ashum@hku.hk-
dc.identifier.authorityShum, HC=rp01439-
dc.identifier.doi10.1021/acsami.5b01984-
dc.identifier.hkuros250690-
dc.identifier.volume7-
dc.identifier.issue19-
dc.identifier.spage10501-
dc.identifier.epage10510-
dc.publisher.placeUnited States-

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