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Article: Osteogenic ability of Cu-bearing stainless steel

TitleOsteogenic ability of Cu-bearing stainless steel
Authors
Issue Date2015
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/
Citation
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015, v. 103 n. 7, p. 1433-1444 How to Cite?
AbstractA newly developed copper-bearing stainless steel (Cu-SS) by directly immobilizing proper amount of Cu into a medical stainless steel (317L SS) during the metallurgical process could enable continuous release of trace amount of Cu2+ ions, which play the key role to offer the multi-biofunctions of the stainless steel, including the osteogenic ability in the present study. The results of in vitro experiments clearly demonstrated that Cu2+ ions from Cu-SS could promote the osteogenic differentiation by stimulating the Alkaline phosphatase enzyme activity and the osteogenic gene expressions (Col1a1, Opn, and Runx2), and enhancing the adhesion and proliferation of osteoblasts cultured on its surface. The in vivo test further proved that more new bone tissue formed around the Cu-SS implant with more stable bone-to-implant contact in comparison with the 317L SS. In addition, Cu-SS showed satisfied biocompatibility according to the results of in vitro cytotoxicity and in vivo histocompatibility, and its daily released amount of Cu2+ ions in physiological saline solution was at trace level of ppb order (1.4 ppb/cm2), which is rather safe to human health. Apart from these results, it was also found that Cu-SS could inhibit the happening of inflammation with lower TNF-α expression in the bone tissue post implantation compared with 317L SS. In addition to good biocompatibility, the overall findings demonstrated that the Cu-SS possessed obvious ability of promoting osteogenesis, indicating a unique application advantage in orthopedics. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1433-1444, 2015. © 2014 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/218787
ISSN
2015 Impact Factor: 2.881
2015 SCImago Journal Rankings: 0.784
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorREN, L-
dc.contributor.authorWong, HM-
dc.contributor.authorYan, CH-
dc.contributor.authorYeung, KWK-
dc.contributor.authorYANG, K-
dc.date.accessioned2015-09-18T06:53:24Z-
dc.date.available2015-09-18T06:53:24Z-
dc.date.issued2015-
dc.identifier.citationJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2015, v. 103 n. 7, p. 1433-1444-
dc.identifier.issn1552-4973-
dc.identifier.urihttp://hdl.handle.net/10722/218787-
dc.description.abstractA newly developed copper-bearing stainless steel (Cu-SS) by directly immobilizing proper amount of Cu into a medical stainless steel (317L SS) during the metallurgical process could enable continuous release of trace amount of Cu2+ ions, which play the key role to offer the multi-biofunctions of the stainless steel, including the osteogenic ability in the present study. The results of in vitro experiments clearly demonstrated that Cu2+ ions from Cu-SS could promote the osteogenic differentiation by stimulating the Alkaline phosphatase enzyme activity and the osteogenic gene expressions (Col1a1, Opn, and Runx2), and enhancing the adhesion and proliferation of osteoblasts cultured on its surface. The in vivo test further proved that more new bone tissue formed around the Cu-SS implant with more stable bone-to-implant contact in comparison with the 317L SS. In addition, Cu-SS showed satisfied biocompatibility according to the results of in vitro cytotoxicity and in vivo histocompatibility, and its daily released amount of Cu2+ ions in physiological saline solution was at trace level of ppb order (1.4 ppb/cm2), which is rather safe to human health. Apart from these results, it was also found that Cu-SS could inhibit the happening of inflammation with lower TNF-α expression in the bone tissue post implantation compared with 317L SS. In addition to good biocompatibility, the overall findings demonstrated that the Cu-SS possessed obvious ability of promoting osteogenesis, indicating a unique application advantage in orthopedics. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1433-1444, 2015. © 2014 Wiley Periodicals, Inc.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/-
dc.relation.ispartofJournal of Biomedical Materials Research Part B: Applied Biomaterials-
dc.rightsJournal of Biomedical Materials Research Part B: Applied Biomaterials. Copyright © John Wiley & Sons, Inc.-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.titleOsteogenic ability of Cu-bearing stainless steel-
dc.typeArticle-
dc.identifier.emailWong, HM: khmwong@hku.hk-
dc.identifier.emailYan, CH: yanchoi@hku.hk-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityYan, CH=rp00303-
dc.identifier.authorityYeung, KWK=rp00309-
dc.identifier.doi10.1002/jbm.b.33318-
dc.identifier.pmid25418073-
dc.identifier.scopuseid_2-s2.0-84941730358-
dc.identifier.hkuros251951-
dc.identifier.volume103-
dc.identifier.issue7-
dc.identifier.spage1433-
dc.identifier.epage1444-
dc.identifier.isiWOS:000363693600011-
dc.publisher.placeUnited States-

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