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Article: Community-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong

TitleCommunity-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong
Authors
Issue Date2015
Citation
PLOS one, 2015, v. 10 n. 4, p. e0125715 How to Cite?
AbstractThe increasing prevalence of HIV-1 among men having sex with men (MSM) calls for an investigation of HIV-1 prevalence and incidence in MSM by early diagnosis to assist with early preventive interventions in Hong Kong. The participants were recruited randomly from MSM communities within a one-year period. Rapid HIV Test (RHT) and real-time dried blood spot (DBS)-based quantitative polymerase chain reaction (DBS-qPCR) were used for the early diagnosis of 474 participants. Risk behavior analysis was performed by studying information obtained from the participants during the study period. The HIV-1 prevalence and incident rates in the studied MSM population were 4.01%(19/474) and 1.47% (7/474), respectively. Three infected participants were found at the acute phase of infection by DBS-qPCR. Only 46.4%(220/474) MSM were using condoms regularly for anal sex. HIV infection significantly correlated with unprotected receptive anal sex and syphilis infection. An increased number of infections was found among foreign MSM in Hong Kong. This study is the first to use DBS-qPCR to identify acutely infected individuals in a community setting and to provide both the prevalence and incident rates of HIV-1 infection among MSM in Hong Kong. The risk analysis provided evidence that behavior intervention strengthening is necessary to fight against the increasing HIV-1 epidemic among MSM in Hong Kong and surrounding regions in Asia.
Persistent Identifierhttp://hdl.handle.net/10722/218776
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
ISI Accession Number ID
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DC FieldValueLanguage
dc.contributor.authorLiang, J-
dc.contributor.authorLiu, L-
dc.contributor.authorChen, M-
dc.contributor.authorLi, MP-
dc.contributor.authorLi, CH-
dc.contributor.authorChan, CC-
dc.contributor.authorTang, X-
dc.contributor.authorPeng, J-
dc.contributor.authorCheung, KW-
dc.contributor.authorYam, WC-
dc.contributor.authorChen, Z-
dc.date.accessioned2015-09-18T06:53:04Z-
dc.date.available2015-09-18T06:53:04Z-
dc.date.issued2015-
dc.identifier.citationPLOS one, 2015, v. 10 n. 4, p. e0125715-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/218776-
dc.description.abstractThe increasing prevalence of HIV-1 among men having sex with men (MSM) calls for an investigation of HIV-1 prevalence and incidence in MSM by early diagnosis to assist with early preventive interventions in Hong Kong. The participants were recruited randomly from MSM communities within a one-year period. Rapid HIV Test (RHT) and real-time dried blood spot (DBS)-based quantitative polymerase chain reaction (DBS-qPCR) were used for the early diagnosis of 474 participants. Risk behavior analysis was performed by studying information obtained from the participants during the study period. The HIV-1 prevalence and incident rates in the studied MSM population were 4.01%(19/474) and 1.47% (7/474), respectively. Three infected participants were found at the acute phase of infection by DBS-qPCR. Only 46.4%(220/474) MSM were using condoms regularly for anal sex. HIV infection significantly correlated with unprotected receptive anal sex and syphilis infection. An increased number of infections was found among foreign MSM in Hong Kong. This study is the first to use DBS-qPCR to identify acutely infected individuals in a community setting and to provide both the prevalence and incident rates of HIV-1 infection among MSM in Hong Kong. The risk analysis provided evidence that behavior intervention strengthening is necessary to fight against the increasing HIV-1 epidemic among MSM in Hong Kong and surrounding regions in Asia.-
dc.languageeng-
dc.relation.ispartofPLOS one-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleCommunity-based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong-
dc.typeArticle-
dc.identifier.emailLiu, L: liuli71@hkucc.hku.hk-
dc.identifier.emailCheung, KW: fayekw@hku.hk-
dc.identifier.emailYam, WC: wcyam@hkucc.hku.hk-
dc.identifier.emailChen, Z: zchenai@hku.hk-
dc.identifier.authorityLiu, L=rp00268-
dc.identifier.authorityYam, WC=rp00313-
dc.identifier.authorityChen, Z=rp00243-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0125715-
dc.identifier.pmid25915755-
dc.identifier.hkuros254396-
dc.identifier.volume10-
dc.identifier.spagee0125715-
dc.identifier.epagee0125715-
dc.identifier.isiWOS:000353659100144-
dc.relation.projectEstablishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system-

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