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Conference Paper: Temporal-medial prefrontal circuitry identified in non-treatment seeking cocaine users predicts relapse in an independent cohort of treated cocaine dependent individuals

TitleTemporal-medial prefrontal circuitry identified in non-treatment seeking cocaine users predicts relapse in an independent cohort of treated cocaine dependent individuals
Authors
KeywordsCocaine addiction
Ttreatment outcome prediction
Morphological and resting state brain activity
Issue Date2015
PublisherNature Publishing Group. The Journal's web site is located at http://www.neuropsychopharmacology.org
Citation
The 54th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2015), Hollywood, FL., 6-10 December 2015. In Neuropsychopharmacology, 2015, v. 40 n. S1, p. S255-S256, abstract no. M237 How to Cite?
AbstractBackground: Both clinical and preclinical data support differences in brain structure and functional connectivity following chronic cocaine use; however, results have not been consistent between studies. To date, few studies have explored the relationship between structural differences and functional network differences in chronic cocaine users, which might improve reliability of results. Further, differences found in cocaine users are not often investigated as predictors of treatment outcome, and have never, to the best of our knowledge, been applied to an independent sample. In this study, we identify brain areas where cortical thickness differs between non-treatment seeking cocaine users (NTSCU) and healthy controls (HC). We then use these areas of difference as seeds in resting connectivity analyses to identify network alterations that relate to the structural differences. Finally, we apply the circuits found to differ between NTSCU and HC to an independent cohort of treated cocaine dependent (TxCD) individuals scanned in the final week of a residential treatment program and followed for six months.
DescriptionPoster Session 1
Persistent Identifierhttp://hdl.handle.net/10722/217927
ISSN
2015 Impact Factor: 6.399
2015 SCImago Journal Rankings: 3.517

 

DC FieldValueLanguage
dc.contributor.authorSalmeron, BJ-
dc.contributor.authorGeng, X-
dc.contributor.authorHu, Y-
dc.contributor.authorGu, H-
dc.contributor.authorAdinoff, B-
dc.contributor.authorStein, E-
dc.contributor.authorYang, Y-
dc.date.accessioned2015-09-18T06:18:26Z-
dc.date.available2015-09-18T06:18:26Z-
dc.date.issued2015-
dc.identifier.citationThe 54th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2015), Hollywood, FL., 6-10 December 2015. In Neuropsychopharmacology, 2015, v. 40 n. S1, p. S255-S256, abstract no. M237-
dc.identifier.issn0893-133X-
dc.identifier.urihttp://hdl.handle.net/10722/217927-
dc.descriptionPoster Session 1-
dc.description.abstractBackground: Both clinical and preclinical data support differences in brain structure and functional connectivity following chronic cocaine use; however, results have not been consistent between studies. To date, few studies have explored the relationship between structural differences and functional network differences in chronic cocaine users, which might improve reliability of results. Further, differences found in cocaine users are not often investigated as predictors of treatment outcome, and have never, to the best of our knowledge, been applied to an independent sample. In this study, we identify brain areas where cortical thickness differs between non-treatment seeking cocaine users (NTSCU) and healthy controls (HC). We then use these areas of difference as seeds in resting connectivity analyses to identify network alterations that relate to the structural differences. Finally, we apply the circuits found to differ between NTSCU and HC to an independent cohort of treated cocaine dependent (TxCD) individuals scanned in the final week of a residential treatment program and followed for six months.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.neuropsychopharmacology.org-
dc.relation.ispartofNeuropsychopharmacology-
dc.subjectCocaine addiction-
dc.subjectTtreatment outcome prediction-
dc.subjectMorphological and resting state brain activity-
dc.titleTemporal-medial prefrontal circuitry identified in non-treatment seeking cocaine users predicts relapse in an independent cohort of treated cocaine dependent individuals-
dc.typeConference_Paper-
dc.identifier.emailGeng, X: gengx@hku.hk-
dc.identifier.authorityGeng, X=rp01678-
dc.identifier.doi10.1038/npp.2015.325-
dc.identifier.hkuros251736-
dc.identifier.volume40-
dc.identifier.issueS1-
dc.identifier.spageS255, abstract no. M237-
dc.identifier.epageS256-
dc.publisher.placeUnited Kingdom-

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