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Conference Paper: Captopril pre-treatment produces additive cardioprotective effects to isoflurane preconditioning in attenuating myocardial ischemia reperfusion injury in rabbits and in humans

TitleCaptopril pre-treatment produces additive cardioprotective effects to isoflurane preconditioning in attenuating myocardial ischemia reperfusion injury in rabbits and in humans
Authors
KeywordsMedical sciences
Anaesthesiology
Issue Date2015
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.anesthesia-analgesia.org
Citation
The 2015 Annual Meeting and International Science Symposium of the International Anesthesia Research Society (IARS), Honolulu, HI., 21-24 March 2015. In Anesthesia and Analgesia, 2015, v. 120 n. 3, p. S-34 How to Cite?
AbstractINTRODUCTION: Pre-treatment with the angiotensin-converting inhibitor captopril or volatile anesthetic isoflurane has, respectively, been shown to attenuate myocardial ischemia reperfusion (MI/R) injury in rodents1 or in patients2 undergoing coronary artery bypass graft (CABG) surgery using cardiopulmonary bypass (CPB). It is unknown whether or not captopril pre-treatment and isoflurane preconditioning may additively or synergistically attenuate MI/R injury. METHODS: Patients (n=100) selected for CABG surgery were randomly assigned to five groups (n=20 per group): untreated control (Control), captopril pre-treatment for 3 days group (group Cap3d, captopril 12.5 mg, p.o., 3 times a day) before surgery or single dose captopril group (group Cap1hr, captopril 12.5 mg, p.o., 1 h before surgery) in the absence or presence of inhalational isoflurane at 1.1% end tidal concentration administrated for 30 min before CPB (in group Cap3d+Iso and Caplhr+Iso). Rabbit in vivo MI/R injury model was induced by occluding the left descending coronary artery for 30 min followed by 2 hours reperfusion. Rabbits (8 per groups) were randomized to receive sham operation (group Sham), MI/R (group I/R), captopril (group Cap, 25 mg/kg given intravenously 24 h prior to inducing MI/R), isoflurane preconditioning (group Iso, 15 min 1.1% end tidal isoflurane followed by a 15 min washout period before inducing MI/R), or the combination of captopril and isoflurane (group Iso+Cap). RESULTS: In patients, 3 days captopril treatment combined with isoflurane (Cap3d+Iso), but not 1 hour captopril treatment combined with isoflurane, additively reduced myocardial injury [reduced plasma cardiac troponin I and creatine kinase MB, P<0.05 vs. all other groups], and attenuated myocardial inflammation (reduced plasma TNFα, IL-6, and ICAM-1), which were associated with reduced the usage of vasoactive drugs after surgery. In rabbits, post-ischemic myocardial infarct size in group Cap or group Iso was significantly lower than that in group I/R (P<0.05). Captopril and isoflurane (Iso+Cap) additively reduced IS (P<0.05 vs. Cap or Iso) and cellular injury that were associated with improved postischemic myocardial functional recovery and reduced myocardial apoptosis and attenuated oxidative stress (all P<0.05 vs. Cap or Iso). CONCLUSIONS: A joint use of 3-day captopril treatment and isoflurane preconditioning additively attenuated MI/R by reducing oxidative stress and inflammation.
DescriptionConference Theme: Improving Health through Discovery and Education
Anesthetic Pharmacology 1: Abstracts in Poster Discussion Round: S-30 – S-34
Persistent Identifierhttp://hdl.handle.net/10722/217819
ISSN
2015 Impact Factor: 3.827
2015 SCImago Journal Rankings: 1.523

 

DC FieldValueLanguage
dc.contributor.authorLi, H-
dc.contributor.authorTian, Y-
dc.contributor.authorLiu, P-
dc.contributor.authorXu, JM-
dc.contributor.authorIrwin, M-
dc.contributor.authorTian, GG-
dc.contributor.authorXia, Z-
dc.date.accessioned2015-09-18T06:14:15Z-
dc.date.available2015-09-18T06:14:15Z-
dc.date.issued2015-
dc.identifier.citationThe 2015 Annual Meeting and International Science Symposium of the International Anesthesia Research Society (IARS), Honolulu, HI., 21-24 March 2015. In Anesthesia and Analgesia, 2015, v. 120 n. 3, p. S-34-
dc.identifier.issn0003-2999-
dc.identifier.urihttp://hdl.handle.net/10722/217819-
dc.descriptionConference Theme: Improving Health through Discovery and Education-
dc.descriptionAnesthetic Pharmacology 1: Abstracts in Poster Discussion Round: S-30 – S-34-
dc.description.abstractINTRODUCTION: Pre-treatment with the angiotensin-converting inhibitor captopril or volatile anesthetic isoflurane has, respectively, been shown to attenuate myocardial ischemia reperfusion (MI/R) injury in rodents1 or in patients2 undergoing coronary artery bypass graft (CABG) surgery using cardiopulmonary bypass (CPB). It is unknown whether or not captopril pre-treatment and isoflurane preconditioning may additively or synergistically attenuate MI/R injury. METHODS: Patients (n=100) selected for CABG surgery were randomly assigned to five groups (n=20 per group): untreated control (Control), captopril pre-treatment for 3 days group (group Cap3d, captopril 12.5 mg, p.o., 3 times a day) before surgery or single dose captopril group (group Cap1hr, captopril 12.5 mg, p.o., 1 h before surgery) in the absence or presence of inhalational isoflurane at 1.1% end tidal concentration administrated for 30 min before CPB (in group Cap3d+Iso and Caplhr+Iso). Rabbit in vivo MI/R injury model was induced by occluding the left descending coronary artery for 30 min followed by 2 hours reperfusion. Rabbits (8 per groups) were randomized to receive sham operation (group Sham), MI/R (group I/R), captopril (group Cap, 25 mg/kg given intravenously 24 h prior to inducing MI/R), isoflurane preconditioning (group Iso, 15 min 1.1% end tidal isoflurane followed by a 15 min washout period before inducing MI/R), or the combination of captopril and isoflurane (group Iso+Cap). RESULTS: In patients, 3 days captopril treatment combined with isoflurane (Cap3d+Iso), but not 1 hour captopril treatment combined with isoflurane, additively reduced myocardial injury [reduced plasma cardiac troponin I and creatine kinase MB, P<0.05 vs. all other groups], and attenuated myocardial inflammation (reduced plasma TNFα, IL-6, and ICAM-1), which were associated with reduced the usage of vasoactive drugs after surgery. In rabbits, post-ischemic myocardial infarct size in group Cap or group Iso was significantly lower than that in group I/R (P<0.05). Captopril and isoflurane (Iso+Cap) additively reduced IS (P<0.05 vs. Cap or Iso) and cellular injury that were associated with improved postischemic myocardial functional recovery and reduced myocardial apoptosis and attenuated oxidative stress (all P<0.05 vs. Cap or Iso). CONCLUSIONS: A joint use of 3-day captopril treatment and isoflurane preconditioning additively attenuated MI/R by reducing oxidative stress and inflammation.-
dc.languageeng-
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.anesthesia-analgesia.org-
dc.relation.ispartofAnesthesia and Analgesia-
dc.rightsThis is a non-final version of an article published in final form in (provide complete journal citation)-
dc.subjectMedical sciences-
dc.subjectAnaesthesiology-
dc.titleCaptopril pre-treatment produces additive cardioprotective effects to isoflurane preconditioning in attenuating myocardial ischemia reperfusion injury in rabbits and in humans-
dc.typeConference_Paper-
dc.identifier.emailIrwin, M: mgirwin@hku.hk-
dc.identifier.emailXia, Z: zyxia@hkucc.hku.hk-
dc.identifier.authorityIrwin, M=rp00390-
dc.identifier.authorityXia, Z=rp00532-
dc.identifier.hkuros252698-
dc.identifier.volume120-
dc.identifier.issue3-
dc.identifier.spageS-34-
dc.identifier.epageS-34-
dc.publisher.placeUnited States-

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