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Conference Paper: Synthesis and characteristics of PEI-based copolymers and nanoparticles for potential gene delivery applications
| Title | Synthesis and characteristics of PEI-based copolymers and nanoparticles for potential gene delivery applications |
|---|---|
| Authors | |
| Issue Date | 2015 |
| Publisher | Society for Biomaterials. |
| Citation | The 2015 Annual Meeting and Exposition of the Society For Biomaterials (SFB 2015), Charlotte, NC., 15-18 April 2015. In Conference Proceedings, 2015, 1pp. How to Cite? |
| Abstract | INTRODUCTION: Gene therapy holds great promise for treating cancer and genetic disorders. Viral vectors are known for high gene transfection efficiency. But safety concerns of viral vectors have greatly limited their clinical applications. Non-viral vectors such as cationic polymers are investigated owing to their ease of preparation, manipulable structures, large DNA loading capability and absence of immune response [He CX, et al., International Journal of Pharmaceutics, 2010, 386 (1-2), 232-242.]. Among these polymers, poly(lactic-co-glycolic acid) (PLGA) and chitosan are extensively used for making
nanoparticles. Poly(ethylenimine) (PEI) with abundant cationic charges has been widely employed for ... |
| Description | Meeting Theme: Driving Biomaterial Innovation and the Race to Translation |
| Persistent Identifier | http://hdl.handle.net/10722/217454 |
| ISBN |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Liu, C | - |
| dc.contributor.author | Wang, M | - |
| dc.date.accessioned | 2015-09-18T05:59:49Z | - |
| dc.date.available | 2015-09-18T05:59:49Z | - |
| dc.date.issued | 2015 | - |
| dc.identifier.citation | The 2015 Annual Meeting and Exposition of the Society For Biomaterials (SFB 2015), Charlotte, NC., 15-18 April 2015. In Conference Proceedings, 2015, 1pp. | - |
| dc.identifier.isbn | 9781510801066 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/217454 | - |
| dc.description | Meeting Theme: Driving Biomaterial Innovation and the Race to Translation | - |
| dc.description.abstract | INTRODUCTION: Gene therapy holds great promise for treating cancer and genetic disorders. Viral vectors are known for high gene transfection efficiency. But safety concerns of viral vectors have greatly limited their clinical applications. Non-viral vectors such as cationic polymers are investigated owing to their ease of preparation, manipulable structures, large DNA loading capability and absence of immune response [He CX, et al., International Journal of Pharmaceutics, 2010, 386 (1-2), 232-242.]. Among these polymers, poly(lactic-co-glycolic acid) (PLGA) and chitosan are extensively used for making nanoparticles. Poly(ethylenimine) (PEI) with abundant cationic charges has been widely employed for ... | - |
| dc.language | eng | - |
| dc.publisher | Society for Biomaterials. | - |
| dc.relation.ispartof | Society For Biomaterials Annual Meeting and Exposition. 39th 2015. Transactions of the 39th Annual Meeting Driving Biomaterial Innovation and the Race to Translation | - |
| dc.title | Synthesis and characteristics of PEI-based copolymers and nanoparticles for potential gene delivery applications | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | Wang, M: memwang@hku.hk | - |
| dc.identifier.authority | Wang, M=rp00185 | - |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 251708 | - |
| dc.publisher.place | United States | - |