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Article: The identity of zona pellucida receptor on spermatozoa: an unresolved issue in developmental biology

TitleThe identity of zona pellucida receptor on spermatozoa: an unresolved issue in developmental biology
Authors
Issue Date2014
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcdb
Citation
Seminars in Cell and Developmental Biology, 2014, v. 30, p. 86-95 How to Cite?
AbstractMammalian oocytes are surrounded by an acellular zona pellucida (ZP). Fertilization begins when a capacitated spermatozoon binds to the ZP. Defective sperm-ZP interaction is a cause of male infertility and reduced fertilization rates in clinical assisted reproduction treatment. Despite the importance of spermatozoa-ZP binding, the mechanisms and regulation of the interaction are unclear partly due to the failure in the identification of ZP receptor on spermatozoa. Most of the previous studies assumed that the sperm ZP receptor is a single molecular species, and a number of potential candidates had been suggested. Yet none of them can be considered as the sole sperm ZP receptor. Accumulated evidence suggested that the sperm ZP receptor is a dynamic multi-molecular structure requiring coordinated action of different proteins that are assembled into a functional complex during post-testicular maturation and capacitation. The complex components may include carbohydrate-binding, protein-binding and acrosomal matrix proteins which work as a suite to mediate spermatozoa-ZP interaction. This article aims to review the latest insights in the identification of the sperm ZP receptor. Continued investigation of the area will provide considerable understanding of the regulation of fertilization that will be useful for practical application in human contraception and reproductive medicine.
Persistent Identifierhttp://hdl.handle.net/10722/217326
ISSN
2015 Impact Factor: 5.181
2015 SCImago Journal Rankings: 4.033
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChiu, CN-
dc.contributor.authorLam, KW-
dc.contributor.authorWONG, CW-
dc.contributor.authorYeung, WSB-
dc.date.accessioned2015-09-18T05:56:09Z-
dc.date.available2015-09-18T05:56:09Z-
dc.date.issued2014-
dc.identifier.citationSeminars in Cell and Developmental Biology, 2014, v. 30, p. 86-95-
dc.identifier.issn1084-9521-
dc.identifier.urihttp://hdl.handle.net/10722/217326-
dc.description.abstractMammalian oocytes are surrounded by an acellular zona pellucida (ZP). Fertilization begins when a capacitated spermatozoon binds to the ZP. Defective sperm-ZP interaction is a cause of male infertility and reduced fertilization rates in clinical assisted reproduction treatment. Despite the importance of spermatozoa-ZP binding, the mechanisms and regulation of the interaction are unclear partly due to the failure in the identification of ZP receptor on spermatozoa. Most of the previous studies assumed that the sperm ZP receptor is a single molecular species, and a number of potential candidates had been suggested. Yet none of them can be considered as the sole sperm ZP receptor. Accumulated evidence suggested that the sperm ZP receptor is a dynamic multi-molecular structure requiring coordinated action of different proteins that are assembled into a functional complex during post-testicular maturation and capacitation. The complex components may include carbohydrate-binding, protein-binding and acrosomal matrix proteins which work as a suite to mediate spermatozoa-ZP interaction. This article aims to review the latest insights in the identification of the sperm ZP receptor. Continued investigation of the area will provide considerable understanding of the regulation of fertilization that will be useful for practical application in human contraception and reproductive medicine.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcdb-
dc.relation.ispartofSeminars in Cell and Developmental Biology-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleThe identity of zona pellucida receptor on spermatozoa: an unresolved issue in developmental biology-
dc.typeArticle-
dc.identifier.emailChiu, CN: pchiucn@hku.hk-
dc.identifier.emailLam, KW: kkwlam@hku.hk-
dc.identifier.emailYeung, WSB: wsbyeung@hku.hk-
dc.identifier.authorityChiu, CN=rp00424-
dc.identifier.authorityYeung, WSB=rp00331-
dc.identifier.doi10.1016/j.semcdb.2014.04.016-
dc.identifier.pmid24747367-
dc.identifier.scopuseid_2-s2.0-84901588061-
dc.identifier.hkuros251371-
dc.identifier.volume30-
dc.identifier.spage86-
dc.identifier.epage95-
dc.identifier.isiWOS:000338617300010-
dc.publisher.placeUnited Kingdom-

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