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Article: Clinical factors affecting rejection rates in liver transplantation

TitleClinical factors affecting rejection rates in liver transplantation
Authors
Keywordsimmunosuppression
acute rejection
liver transplantation
Issue Date2015
PublisherThe First Affiliated Hospital, Zhejiang University School of Medicine. The Journal's web site is located at http://www.hbpdint.com/
Citation
Hepatobiliary & Pancreatic Diseases International, 2015, v. 14 n. 4, p. 367-373 How to Cite?
Abstract© 2015 The Editorial Board of Hepatobiliary & Pancreatic Diseases International. All rights reserved. Background With improvements in survival, liver transplant recipients now suffer more morbidity from long-term immunosuppression. Considerations were given to develop individualized immunosuppression based on their risk of rejection. Method We retrospectively analyzed the data of 788 liver transplants performed during the period from October 1991 to December 2011 to study the relationship between acute cellular rejection (ACR) and various clinical factors. Results Multivariate analysis showed that older age (P=0.04, OR=0.982), chronic hepatitis B virus infection (P=0.005, OR= 0.574), living donor liver transplantation (P=0.02, OR=0.648) and use of interleukin-2 receptor antagonist on induction (P<0.001, OR=0.401) were associated with fewer ACRs. Patients with fulminant liver failure (P=0.004, OR=4.05) were more likely to develop moderate to severe grade ACR. Conclusions Liver transplant recipients with older age, chronic hepatitis B virus infection, living donor liver transplantation and use of interleukin-2 receptor antagonist on induction have fewer ACR. Patients transplanted for fulminant liver failure are at higher risk of moderate to severe grade ACR. These results provide theoretical framework for developing individualized immunosuppression.
Persistent Identifierhttp://hdl.handle.net/10722/217265
ISSN
2015 Impact Factor: 1.724
2015 SCImago Journal Rankings: 0.717

 

DC FieldValueLanguage
dc.contributor.authorAu, KP-
dc.contributor.authorChan, SC-
dc.contributor.authorChok, KSH-
dc.contributor.authorSharr, WW-
dc.contributor.authorDai, WC-
dc.contributor.authorSin, SL-
dc.contributor.authorWong, CLT-
dc.contributor.authorLo, CM-
dc.date.accessioned2015-09-18T05:54:21Z-
dc.date.available2015-09-18T05:54:21Z-
dc.date.issued2015-
dc.identifier.citationHepatobiliary & Pancreatic Diseases International, 2015, v. 14 n. 4, p. 367-373-
dc.identifier.issn1499-3872-
dc.identifier.urihttp://hdl.handle.net/10722/217265-
dc.description.abstract© 2015 The Editorial Board of Hepatobiliary & Pancreatic Diseases International. All rights reserved. Background With improvements in survival, liver transplant recipients now suffer more morbidity from long-term immunosuppression. Considerations were given to develop individualized immunosuppression based on their risk of rejection. Method We retrospectively analyzed the data of 788 liver transplants performed during the period from October 1991 to December 2011 to study the relationship between acute cellular rejection (ACR) and various clinical factors. Results Multivariate analysis showed that older age (P=0.04, OR=0.982), chronic hepatitis B virus infection (P=0.005, OR= 0.574), living donor liver transplantation (P=0.02, OR=0.648) and use of interleukin-2 receptor antagonist on induction (P<0.001, OR=0.401) were associated with fewer ACRs. Patients with fulminant liver failure (P=0.004, OR=4.05) were more likely to develop moderate to severe grade ACR. Conclusions Liver transplant recipients with older age, chronic hepatitis B virus infection, living donor liver transplantation and use of interleukin-2 receptor antagonist on induction have fewer ACR. Patients transplanted for fulminant liver failure are at higher risk of moderate to severe grade ACR. These results provide theoretical framework for developing individualized immunosuppression.-
dc.languageeng-
dc.publisherThe First Affiliated Hospital, Zhejiang University School of Medicine. The Journal's web site is located at http://www.hbpdint.com/-
dc.relation.ispartofHepatobiliary & Pancreatic Diseases International-
dc.subjectimmunosuppression-
dc.subjectacute rejection-
dc.subjectliver transplantation-
dc.titleClinical factors affecting rejection rates in liver transplantation-
dc.typeArticle-
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hk-
dc.identifier.emailChok, KSH: chok6275@hku.hk-
dc.identifier.emailSharr, WW: wwsharr@hku.hk-
dc.identifier.emailDai, WC: daiwc@hku.hk-
dc.identifier.emailWong, CLT: wongtcl@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityChan, SC=rp01568-
dc.identifier.authorityWong, CLT=rp01679-
dc.identifier.authorityLo, CM=rp00412-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S1499-3872(15)60391-5-
dc.identifier.pmid26256080-
dc.identifier.scopuseid_2-s2.0-84941889373-
dc.identifier.hkuros254785-
dc.identifier.hkuros251764-
dc.identifier.volume14-
dc.identifier.issue4-
dc.identifier.spage367-
dc.identifier.epage373-
dc.publisher.placeChina-

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