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Article: CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain

TitleCXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain
Authors
Issue Date2016
PublisherWalter de Gruyter GmbH. The Journal's web site is located at http://www.degruyter.com/view/j/revneuro
Citation
Reviews in the Neurosciences, 2016, v. 27 n. 1, p. 83-92 How to Cite?
AbstractThe roles of chemokine C-X-C motif ligand 12 (CXCL12) and its receptor chemokine C-X-C motif receptor 4 (CXCR4) reveal this chemokine axis as an emerging neuromodulator in the nervous system. In the peripheral and central nervous systems, both CXCL12 and CXCR4 are expressed in various kinds of nociceptive structures, and CXCL12/CXCR4 axis possesses pronociceptive property. Recent studies have demonstrated its critical roles in the development and maintenance of pathological pain, and both neuronal and glial mechanisms are involved in this CXCL12/CXCR4 axis-mediated pain processing. In this review, we summarize the recent development of the roles and mechanisms of CXCL12/CXCR4 axis in the pathogenesis of chronic pain by sciatic nerve injury, human immunodeficiency virus-associated sensory neuropathy, diabetic neuropathy, spinal cord injury, bone cancer, opioid tolerance, or opioid-induced hyperalgesia. The potential targeting of CXCL12/CXCR4 axis as an effective and broad-spectrum pharmacological approach for chronic pain therapy was also discussed.
Persistent Identifierhttp://hdl.handle.net/10722/216724
ISSN
2015 Impact Factor: 3.198
2015 SCImago Journal Rankings: 1.605

 

DC FieldValueLanguage
dc.contributor.authorLuo, X-
dc.contributor.authorWang, XMA-
dc.contributor.authorXia, Z-
dc.contributor.authorChung, SK-
dc.contributor.authorCheung, CW-
dc.date.accessioned2015-09-18T05:36:44Z-
dc.date.available2015-09-18T05:36:44Z-
dc.date.issued2016-
dc.identifier.citationReviews in the Neurosciences, 2016, v. 27 n. 1, p. 83-92-
dc.identifier.issn0334-1763-
dc.identifier.urihttp://hdl.handle.net/10722/216724-
dc.description.abstractThe roles of chemokine C-X-C motif ligand 12 (CXCL12) and its receptor chemokine C-X-C motif receptor 4 (CXCR4) reveal this chemokine axis as an emerging neuromodulator in the nervous system. In the peripheral and central nervous systems, both CXCL12 and CXCR4 are expressed in various kinds of nociceptive structures, and CXCL12/CXCR4 axis possesses pronociceptive property. Recent studies have demonstrated its critical roles in the development and maintenance of pathological pain, and both neuronal and glial mechanisms are involved in this CXCL12/CXCR4 axis-mediated pain processing. In this review, we summarize the recent development of the roles and mechanisms of CXCL12/CXCR4 axis in the pathogenesis of chronic pain by sciatic nerve injury, human immunodeficiency virus-associated sensory neuropathy, diabetic neuropathy, spinal cord injury, bone cancer, opioid tolerance, or opioid-induced hyperalgesia. The potential targeting of CXCL12/CXCR4 axis as an effective and broad-spectrum pharmacological approach for chronic pain therapy was also discussed.-
dc.languageeng-
dc.publisherWalter de Gruyter GmbH. The Journal's web site is located at http://www.degruyter.com/view/j/revneuro-
dc.relation.ispartofReviews in the Neurosciences-
dc.rightsThe final publication is available at www.degruyter.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleCXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain-
dc.typeArticle-
dc.identifier.emailWang, XMA: xmwang1@hku.hk-
dc.identifier.emailXia, Z: zyxia@hkucc.hku.hk-
dc.identifier.emailChung, SK: skchung@hkucc.hku.hk-
dc.identifier.emailCheung, CW: cheucw@hku.hk-
dc.identifier.authorityXia, Z=rp00532-
dc.identifier.authorityChung, SK=rp00381-
dc.identifier.authorityCheung, CW=rp00244-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1515/revneuro-2015-0016-
dc.identifier.pmid26353174-
dc.identifier.hkuros252588-
dc.identifier.volume27-
dc.identifier.issue1-
dc.identifier.spage83-
dc.identifier.epage92-
dc.publisher.placeGermany-

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