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Article: SIRTain regulators of premature senescence and accelerated aging.

TitleSIRTain regulators of premature senescence and accelerated aging.
Authors
Issue Date2015
PublisherSPRINGER/Higher Education Press.
Citation
Protein & Cell, 2015, v. 6, p. 322-333 How to Cite?
AbstractThe sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent roles in maintaining metabolic homeostasis, safeguarding genomic integrity, regulating cancer metabolism and also inflammatory responses. Amongst the seven known mammalian sirtuin proteins, SIRT1 has gained much attention due to its widely acknowledged roles in promoting longevity and ameliorating age-associated pathologies. The contributions of other sirtuins in the field of aging are also gradually emerging. Here, we summarize some of the recent discoveries in sirtuins biology which clearly implicate the functions of sirtuin proteins in the regulation of premature cellular senescence and accelerated aging. The roles of sirtuins in various cellular processes have been extrapolated to draw inter-linkage with anti-aging mechanisms. Also, the latest findings on sirtuins which might have potential effects in the process of aging have been reviewed.
Persistent Identifierhttp://hdl.handle.net/10722/216597

 

DC FieldValueLanguage
dc.contributor.authorGhosh, S-
dc.contributor.authorZhou, Z-
dc.date.accessioned2015-09-18T05:33:21Z-
dc.date.available2015-09-18T05:33:21Z-
dc.date.issued2015-
dc.identifier.citationProtein & Cell, 2015, v. 6, p. 322-333-
dc.identifier.urihttp://hdl.handle.net/10722/216597-
dc.description.abstractThe sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent roles in maintaining metabolic homeostasis, safeguarding genomic integrity, regulating cancer metabolism and also inflammatory responses. Amongst the seven known mammalian sirtuin proteins, SIRT1 has gained much attention due to its widely acknowledged roles in promoting longevity and ameliorating age-associated pathologies. The contributions of other sirtuins in the field of aging are also gradually emerging. Here, we summarize some of the recent discoveries in sirtuins biology which clearly implicate the functions of sirtuin proteins in the regulation of premature cellular senescence and accelerated aging. The roles of sirtuins in various cellular processes have been extrapolated to draw inter-linkage with anti-aging mechanisms. Also, the latest findings on sirtuins which might have potential effects in the process of aging have been reviewed.-
dc.languageeng-
dc.publisherSPRINGER/Higher Education Press.-
dc.relation.ispartofProtein & Cell-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleSIRTain regulators of premature senescence and accelerated aging.-
dc.typeArticle-
dc.identifier.emailZhou, Z: zhongjun@hku.hk-
dc.identifier.authorityZhou, Z=rp00503-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1007/s13238-015-0149-1-
dc.identifier.hkuros251744-
dc.identifier.volume6-
dc.identifier.spage322-
dc.identifier.epage333-

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