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Article: Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis

TitleFatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis
Authors
KeywordsAnti-aquaporin-4 antibody
Neuromyelitis optica
Tuberculosis
Issue Date2014
Citation
BMC Infectious Diseases, 2014, v. 14, p. 470 How to Cite?
Abstract© 2014 Sridhar et al.; licensee BioMed Central Ltd.Background: Neuromyelitis optica (NMO) is an autoimmune inflammatory condition of the central nervous system that is characterized by circulating anti-aquaporin-4 antibodies, transverse myelitis and optic neuritis. NMO spectrum disorders are rarely reported in patients with active pulmonary tuberculosis (TB). We report a fatal case of anti-aquaporin-4 antibody positive NMO spectrum disorder in a patient who was receiving treatment for pulmonary tuberculosis. Case presentation: A previously healthy 42-year-old Chinese man was diagnosed with smear positive pulmonary tuberculosis. After one month of anti-tuberculosis treatment, he presented with acute generalized weakness and rapid neurological deterioration. Spinal imaging and anti-aquaporin-4 antibody positivity established a diagnosis of neuromyelitis optica spectrum disorder. Conclusion: This is the first reported case of anti-aquaporin-4 antibody-positive NMO spectrum disorder in a patient with active tuberculosis. It shows the usefulness of testing for anti-aquaporin-4 antibodies while evaluating neurological deterioration in patients with tuberculosis. The literature on the rare association between NMO spectrum disorders and TB is reviewed.
Persistent Identifierhttp://hdl.handle.net/10722/216539

 

DC FieldValueLanguage
dc.contributor.authorSridhar, S-
dc.contributor.authorChan, JFW-
dc.contributor.authorYuen, KY-
dc.date.accessioned2015-09-18T05:30:55Z-
dc.date.available2015-09-18T05:30:55Z-
dc.date.issued2014-
dc.identifier.citationBMC Infectious Diseases, 2014, v. 14, p. 470-
dc.identifier.urihttp://hdl.handle.net/10722/216539-
dc.description.abstract© 2014 Sridhar et al.; licensee BioMed Central Ltd.Background: Neuromyelitis optica (NMO) is an autoimmune inflammatory condition of the central nervous system that is characterized by circulating anti-aquaporin-4 antibodies, transverse myelitis and optic neuritis. NMO spectrum disorders are rarely reported in patients with active pulmonary tuberculosis (TB). We report a fatal case of anti-aquaporin-4 antibody positive NMO spectrum disorder in a patient who was receiving treatment for pulmonary tuberculosis. Case presentation: A previously healthy 42-year-old Chinese man was diagnosed with smear positive pulmonary tuberculosis. After one month of anti-tuberculosis treatment, he presented with acute generalized weakness and rapid neurological deterioration. Spinal imaging and anti-aquaporin-4 antibody positivity established a diagnosis of neuromyelitis optica spectrum disorder. Conclusion: This is the first reported case of anti-aquaporin-4 antibody-positive NMO spectrum disorder in a patient with active tuberculosis. It shows the usefulness of testing for anti-aquaporin-4 antibodies while evaluating neurological deterioration in patients with tuberculosis. The literature on the rare association between NMO spectrum disorders and TB is reviewed.-
dc.languageeng-
dc.relation.ispartofBMC Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAnti-aquaporin-4 antibody-
dc.subjectNeuromyelitis optica-
dc.subjectTuberculosis-
dc.titleFatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis-
dc.typeArticle-
dc.identifier.emailSridhar, S: sid8998@hku.hk-
dc.identifier.emailChan, JFW: jfwchan@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityChan, JFW=rp01736-
dc.identifier.authorityYuen, KY=rp00366-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1471-2334-14-470-
dc.identifier.pmid25169022-
dc.identifier.scopuseid_2-s2.0-84906825630-
dc.identifier.hkuros253232-
dc.identifier.volume14-
dc.identifier.spage470-
dc.identifier.epage470-

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