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Article: Infection Control Preparedness for Human Infection With Influenza A H7N9 in Hong Kong

TitleInfection Control Preparedness for Human Infection With Influenza A H7N9 in Hong Kong
Authors
Issue Date2015
PublisherUniversity of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/ICHE/home.html
Citation
Infection Control & Hospital Epidemiology, 2015, v. 36 n. 1, p. 87-92 How to Cite?
AbstractObjective. To assess the effectiveness of infection control preparedness for human infection with influenza A H7N9 in Hong Kong Design. A descriptive study of responses to the emergence of influenza A H7N9 Setting. A university-affiliated teaching hospital Participants. Healthcare workers (HCWs) with unprotected exposure (not wearing N95 respirator during aerosol-generating procedure) to a patient with influenza A H7N9 Methods. A bundle approach including active and enhanced surveillance, early airborne infection isolation, rapid molecular diagnostic testing, and extensive contact tracing for HCWs with unprotected exposure was implemented. Seventy HCWs with unprotected exposure to an index case were interviewed especially regarding their patient care activities Results. From April 1, 2013, through May 31, 2014, a total of 126 (0.08%) of 163,456 admitted patients were tested for the H7 gene by reverse transcription-polymerase chain reaction per protocol. Two confirmed cases were identified. Seventy (53.8%) of 130 HCWs had unprotected exposure to an index case, whereas 41 (58.6%) and 58 (82.9%) of 70 HCWs wore surgical masks and practiced hand hygiene after patient care, respectively. Sixteen (22.9%) of 70 HCWs were involved in high-risk patient contacts. More HCWs with high-risk patient contacts received oseltamivir prophylaxis (P= 0.088) and significantly more had paired sera collected for H7 antibody testing (P<0.001). Ten (14.3%) of 70 HCWs developed influenza-like illness during medical surveillance, but none had positive results by reverse transcriptionpolymerase chain reaction. Paired sera was available from 33 of 70 HCWs with unprotected exposure, and none showed seroconversion against H7N9 Conclusions. Despite the delay in airborne precautions implementation, no patient-to-HCW transmission of influenza A H7N9 was demonstrated. © 2015 by The Society for Healthcare Epidemiology of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/216538
ISSN
2015 Impact Factor: 3.669
2015 SCImago Journal Rankings: 1.985
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, VCC-
dc.contributor.authorTai, JW-
dc.contributor.authorLee, WM-
dc.contributor.authorChan, WM-
dc.contributor.authorWong, SCY-
dc.contributor.authorChen, JHK-
dc.contributor.authorPoon, WSR-
dc.contributor.authorTo, KKW-
dc.contributor.authorChan, JFW-
dc.contributor.authorHo, PL-
dc.contributor.authorChan, KH-
dc.contributor.authorYuen, KY-
dc.date.accessioned2015-09-18T05:30:50Z-
dc.date.available2015-09-18T05:30:50Z-
dc.date.issued2015-
dc.identifier.citationInfection Control & Hospital Epidemiology, 2015, v. 36 n. 1, p. 87-92-
dc.identifier.issn0899-823X-
dc.identifier.urihttp://hdl.handle.net/10722/216538-
dc.description.abstractObjective. To assess the effectiveness of infection control preparedness for human infection with influenza A H7N9 in Hong Kong Design. A descriptive study of responses to the emergence of influenza A H7N9 Setting. A university-affiliated teaching hospital Participants. Healthcare workers (HCWs) with unprotected exposure (not wearing N95 respirator during aerosol-generating procedure) to a patient with influenza A H7N9 Methods. A bundle approach including active and enhanced surveillance, early airborne infection isolation, rapid molecular diagnostic testing, and extensive contact tracing for HCWs with unprotected exposure was implemented. Seventy HCWs with unprotected exposure to an index case were interviewed especially regarding their patient care activities Results. From April 1, 2013, through May 31, 2014, a total of 126 (0.08%) of 163,456 admitted patients were tested for the H7 gene by reverse transcription-polymerase chain reaction per protocol. Two confirmed cases were identified. Seventy (53.8%) of 130 HCWs had unprotected exposure to an index case, whereas 41 (58.6%) and 58 (82.9%) of 70 HCWs wore surgical masks and practiced hand hygiene after patient care, respectively. Sixteen (22.9%) of 70 HCWs were involved in high-risk patient contacts. More HCWs with high-risk patient contacts received oseltamivir prophylaxis (P= 0.088) and significantly more had paired sera collected for H7 antibody testing (P<0.001). Ten (14.3%) of 70 HCWs developed influenza-like illness during medical surveillance, but none had positive results by reverse transcriptionpolymerase chain reaction. Paired sera was available from 33 of 70 HCWs with unprotected exposure, and none showed seroconversion against H7N9 Conclusions. Despite the delay in airborne precautions implementation, no patient-to-HCW transmission of influenza A H7N9 was demonstrated. © 2015 by The Society for Healthcare Epidemiology of America. All rights reserved.-
dc.languageeng-
dc.publisherUniversity of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/ICHE/home.html-
dc.relation.ispartofInfection Control & Hospital Epidemiology-
dc.rightsInfection Control & Hospital Epidemiology. Copyright © University of Chicago Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleInfection Control Preparedness for Human Infection With Influenza A H7N9 in Hong Kong-
dc.typeArticle-
dc.identifier.emailCheng, VCC: vcccheng@hkucc.hku.hk-
dc.identifier.emailWong, SCY: wcy288@hku.hk-
dc.identifier.emailChen, JHK: jonchk@hku.hk-
dc.identifier.emailPoon, WSR: rosana@hkucc.hku.hk-
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hk-
dc.identifier.emailChan, JFW: jfwchan@hku.hk-
dc.identifier.emailHo, PL: plho@hkucc.hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityTo, KKW=rp01384-
dc.identifier.authorityChan, JFW=rp01736-
dc.identifier.authorityHo, PL=rp00406-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authorityYuen, KY=rp00366-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1017/ice.2014.2-
dc.identifier.pmid25627766-
dc.identifier.scopuseid_2-s2.0-84922820210-
dc.identifier.hkuros253228-
dc.identifier.volume36-
dc.identifier.issue1-
dc.identifier.spage87-
dc.identifier.epage92-
dc.identifier.isiWOS:000348588800013-
dc.publisher.placeUnited States-

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