Lycium Barbarum: Neuroprotective Effects in Ischemic Stroke

Abstract

Ischemic stroke is a leading cause of death worldwide, bringing about serious long-lasting disability and considerable social burden. Stroke patients suffer from various disabilities, including hemiplegia, dysesthesia, ataxia, and sometimes visual impairment. During an ischemic stroke, ischemia takes place due to blood flow interruption as a result of a cerebral artery blockade. The disruption in oxygen and glucose supply and subsequent reperfusion trigger a complex cascade of molecular events that eventually results in irreversible cell death in the affected brain area, affecting the functioning of the body. Treatment of ischemic stroke is important to alleviate the subsequent outcome. Yet, no ideal neuroprotective agents are available. Some research has turned to traditional medicine that has shown efficacy in animal models, making it an attractive option in the treatment of ischemic stroke. Another appealing alternative would be the prevention of ischemic stroke using traditional medicine, which may be beneficial for patients at high risk for ischemic stroke. One traditional medicine that shows promising results is Lycium barbarum (wolfberry, Goji, Fructus Lycii), an important traditional medicine in promoting health and longevity as well as a food supplement in the Western countries.