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Article: In situ forming poly(ethylene glycol)-based hydrogels via thiol-maleimide Michael-type addition

TitleIn situ forming poly(ethylene glycol)-based hydrogels via thiol-maleimide Michael-type addition
Authors
Keywordssemi-interpenetrating network
poly(ethylene glycol)
Michael-type addition
hydrogel
gelatin
cell adhesion
Issue Date2011
Citation
Journal of Biomedical Materials Research - Part A, 2011, v. 98 A, n. 2, p. 201-211 How to Cite?
AbstractThe incorporation of cells and sensitive compounds can be better facilitated without the presence of UV or other energy sources that are common in the formation of biomedical hydrogels such as poly(ethylene glycol) hydrogels. The formation of hydrogels by the step-growth polymerization of maleimide- and thiol-terminated poly(ethylene glycol) macromers via Michael-type addition is described. The effects of macromer concentration, pH, temperature, and the presence of biomolecule gelatin on gel formation were investigated. Reaction kinetics between maleimide and thiol functional groups were found to be rapid. Molecular weight increase over time was characterized via gel permeation chromatography during step-growth polymerization. Swelling and degradation results showed incorporating gelatin enhanced swelling and accelerated degradation. Increasing gelatin content resulted in the decreased storage modulus (G′). The in vitro release kinetics of fluorescein isothiocyanate (FITC)-labeled dextran from the resulting matrices demonstrated the potential in the development of novel in situ gel-forming drug delivery systems. Moreover, the resulting networks were minimally adhesive to primary human monocytes, fibroblasts, and keratinocytes thus providing an ideal platform for further biofunctionalizations to direct specific biological response. Copyright © 2011 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/216210
ISSN
2015 Impact Factor: 3.263
2015 SCImago Journal Rankings: 0.979

 

DC FieldValueLanguage
dc.contributor.authorFu, Yao-
dc.contributor.authorKao, Weiyuan John-
dc.date.accessioned2015-08-25T10:22:27Z-
dc.date.available2015-08-25T10:22:27Z-
dc.date.issued2011-
dc.identifier.citationJournal of Biomedical Materials Research - Part A, 2011, v. 98 A, n. 2, p. 201-211-
dc.identifier.issn1549-3296-
dc.identifier.urihttp://hdl.handle.net/10722/216210-
dc.description.abstractThe incorporation of cells and sensitive compounds can be better facilitated without the presence of UV or other energy sources that are common in the formation of biomedical hydrogels such as poly(ethylene glycol) hydrogels. The formation of hydrogels by the step-growth polymerization of maleimide- and thiol-terminated poly(ethylene glycol) macromers via Michael-type addition is described. The effects of macromer concentration, pH, temperature, and the presence of biomolecule gelatin on gel formation were investigated. Reaction kinetics between maleimide and thiol functional groups were found to be rapid. Molecular weight increase over time was characterized via gel permeation chromatography during step-growth polymerization. Swelling and degradation results showed incorporating gelatin enhanced swelling and accelerated degradation. Increasing gelatin content resulted in the decreased storage modulus (G′). The in vitro release kinetics of fluorescein isothiocyanate (FITC)-labeled dextran from the resulting matrices demonstrated the potential in the development of novel in situ gel-forming drug delivery systems. Moreover, the resulting networks were minimally adhesive to primary human monocytes, fibroblasts, and keratinocytes thus providing an ideal platform for further biofunctionalizations to direct specific biological response. Copyright © 2011 Wiley Periodicals, Inc.-
dc.languageeng-
dc.relation.ispartofJournal of Biomedical Materials Research - Part A-
dc.subjectsemi-interpenetrating network-
dc.subjectpoly(ethylene glycol)-
dc.subjectMichael-type addition-
dc.subjecthydrogel-
dc.subjectgelatin-
dc.subjectcell adhesion-
dc.titleIn situ forming poly(ethylene glycol)-based hydrogels via thiol-maleimide Michael-type addition-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.a.33106-
dc.identifier.pmid21548071-
dc.identifier.scopuseid_2-s2.0-79959499733-
dc.identifier.volume98 A-
dc.identifier.issue2-
dc.identifier.spage201-
dc.identifier.epage211-
dc.identifier.eissn1552-4965-

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