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Article: Concurrent in vitro release of silver sulfadiazine and bupivacaine from semi-interpenetrating networks for wound management

TitleConcurrent in vitro release of silver sulfadiazine and bupivacaine from semi-interpenetrating networks for wound management
Authors
Issue Date2009
Citation
Journal of Burn Care and Research, 2009, v. 30, n. 1, p. 98-104 How to Cite?
AbstractIn situ photopolymerized semi-interpenetrating networks (sIPNs) composed of poly(ethylene glycol) and gelatin are promising multifunctional matrices for a regenerative medicine approach to dermal wound treatment. In addition to previously demonstrated efficacy in critical defects, sIPNs also function as drug delivery matrices for compounds loaded as either soluble or covalently linked components. Simultaneous release of silver sulfadiazine and bupivacaine from the sIPN would provide multiple-hit management of dermal wounds that minimizes infection, and manages pain along with sIPN absorption of exudates and facilitation of epidermal regrowth. We characterized the release of soluble silver sulfadiazine and bupivacaine and compared it with an established release model. Efficacy of released silver sulfadiazine was confirmed in vitro on Staphylococcus aureus, methicillin resistant S. aureus, and Pseudomonas aeruginosa. Bupivacaine loaded without silver sulfadiazine showed incomplete release, whereas simultaneous loading with silver sulfadiazine facilitated 100% bupivacaine release. Silver sulfadiazine released at 98% without bupivacaine and 96% with bupivacaine. Silver sulfadiazine released onto bacterial cultures inhibited all three strains dose dependently. sIPNs effectively release bupivacaine and silver sulfadiazine while maintaining the antimicrobial activity of silver sulfadiazine. Drug loaded sIPNs have potential to improve wound management by providing multi-drug delivery along with an effective wound treatment. Copyright © 2009 by the American Burn Association.
Persistent Identifierhttp://hdl.handle.net/10722/216197
ISSN
2015 Impact Factor: 1.37
2015 SCImago Journal Rankings: 0.713

 

DC FieldValueLanguage
dc.contributor.authorKleinbeck, Kyle R.-
dc.contributor.authorBader, Rebecca A.-
dc.contributor.authorKao, Weiyuan John-
dc.date.accessioned2015-08-25T10:22:22Z-
dc.date.available2015-08-25T10:22:22Z-
dc.date.issued2009-
dc.identifier.citationJournal of Burn Care and Research, 2009, v. 30, n. 1, p. 98-104-
dc.identifier.issn1559-047X-
dc.identifier.urihttp://hdl.handle.net/10722/216197-
dc.description.abstractIn situ photopolymerized semi-interpenetrating networks (sIPNs) composed of poly(ethylene glycol) and gelatin are promising multifunctional matrices for a regenerative medicine approach to dermal wound treatment. In addition to previously demonstrated efficacy in critical defects, sIPNs also function as drug delivery matrices for compounds loaded as either soluble or covalently linked components. Simultaneous release of silver sulfadiazine and bupivacaine from the sIPN would provide multiple-hit management of dermal wounds that minimizes infection, and manages pain along with sIPN absorption of exudates and facilitation of epidermal regrowth. We characterized the release of soluble silver sulfadiazine and bupivacaine and compared it with an established release model. Efficacy of released silver sulfadiazine was confirmed in vitro on Staphylococcus aureus, methicillin resistant S. aureus, and Pseudomonas aeruginosa. Bupivacaine loaded without silver sulfadiazine showed incomplete release, whereas simultaneous loading with silver sulfadiazine facilitated 100% bupivacaine release. Silver sulfadiazine released at 98% without bupivacaine and 96% with bupivacaine. Silver sulfadiazine released onto bacterial cultures inhibited all three strains dose dependently. sIPNs effectively release bupivacaine and silver sulfadiazine while maintaining the antimicrobial activity of silver sulfadiazine. Drug loaded sIPNs have potential to improve wound management by providing multi-drug delivery along with an effective wound treatment. Copyright © 2009 by the American Burn Association.-
dc.languageeng-
dc.relation.ispartofJournal of Burn Care and Research-
dc.titleConcurrent in vitro release of silver sulfadiazine and bupivacaine from semi-interpenetrating networks for wound management-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1097/BCR.0b013e3181921ed9-
dc.identifier.pmid19060724-
dc.identifier.scopuseid_2-s2.0-59449096855-
dc.identifier.volume30-
dc.identifier.issue1-
dc.identifier.spage98-
dc.identifier.epage104-
dc.identifier.eissn1559-0488-

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