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Article: Tissue adhesiveness and host response of in situ photopolymerizable interpenetrating networks containing methylprednisolone acetate

TitleTissue adhesiveness and host response of in situ photopolymerizable interpenetrating networks containing methylprednisolone acetate
Authors
KeywordsPolyethylene glycol
Peel test
Hydrogel
Gelatin
Drug delivery
Issue Date2004
Citation
Journal of Biomedical Materials Research - Part A, 2004, v. 68, n. 2, p. 392-400 How to Cite?
AbstractInterpenetrating networks (IPNs) of varying formulations were investigated as candidates for an in situ photopolymerizable drug delivery matrix containing poly-(ethylene glycol) diacrylate and gelatin. The anti-inflammatory agent methylprednisolone acetate was loaded into the IPN. Bond strength between the IPN and tissue (i.e., muscle, dermis, skin) was determined by a modified American Society for Testing and Materials peel test at constant peel rate. The IPNs provided adhesion values of up to 5.7N, which were three- to fivefold lower than that of the commercial tissue bioadhesive. The subcutaneous cage implant system was utilized to assess material host response and drug efficacy in vivo. IPN formulations elicited a more intense acute inflammatory response than the empty cage controls. Methylprednisolone acetate loaded within the IPNs lowered the level of inflammatory response to levels that were comparable to the empty cage baseline controls. In conclusion, a methodology was developed to quantify the tissue adhesiveness of an in situ photopolymerized IPN matrix containing anti-inflammatory agents. The efficacy of drug-loaded IPN in affecting the host inflammatory response was demonstrated in vivo. © 2003 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/216179
ISSN
2004 Impact Factor: 3.652
2006 SCImago Journal Rankings: 0.474

 

DC FieldValueLanguage
dc.contributor.authorZilinski, Jodi L.-
dc.contributor.authorKao, Weiyuan John-
dc.date.accessioned2015-08-25T10:22:13Z-
dc.date.available2015-08-25T10:22:13Z-
dc.date.issued2004-
dc.identifier.citationJournal of Biomedical Materials Research - Part A, 2004, v. 68, n. 2, p. 392-400-
dc.identifier.issn0021-9304-
dc.identifier.urihttp://hdl.handle.net/10722/216179-
dc.description.abstractInterpenetrating networks (IPNs) of varying formulations were investigated as candidates for an in situ photopolymerizable drug delivery matrix containing poly-(ethylene glycol) diacrylate and gelatin. The anti-inflammatory agent methylprednisolone acetate was loaded into the IPN. Bond strength between the IPN and tissue (i.e., muscle, dermis, skin) was determined by a modified American Society for Testing and Materials peel test at constant peel rate. The IPNs provided adhesion values of up to 5.7N, which were three- to fivefold lower than that of the commercial tissue bioadhesive. The subcutaneous cage implant system was utilized to assess material host response and drug efficacy in vivo. IPN formulations elicited a more intense acute inflammatory response than the empty cage controls. Methylprednisolone acetate loaded within the IPNs lowered the level of inflammatory response to levels that were comparable to the empty cage baseline controls. In conclusion, a methodology was developed to quantify the tissue adhesiveness of an in situ photopolymerized IPN matrix containing anti-inflammatory agents. The efficacy of drug-loaded IPN in affecting the host inflammatory response was demonstrated in vivo. © 2003 Wiley Periodicals, Inc.-
dc.languageeng-
dc.relation.ispartofJournal of Biomedical Materials Research - Part A-
dc.subjectPolyethylene glycol-
dc.subjectPeel test-
dc.subjectHydrogel-
dc.subjectGelatin-
dc.subjectDrug delivery-
dc.titleTissue adhesiveness and host response of in situ photopolymerizable interpenetrating networks containing methylprednisolone acetate-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.pmid14704982-
dc.identifier.scopuseid_2-s2.0-1942517440-
dc.identifier.volume68-
dc.identifier.issue2-
dc.identifier.spage392-
dc.identifier.epage400-

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