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Conference Paper: In situ photopolymerizable drug delivery matrix: Tensile property, degradation products, tissue adhesiveness, and efficacy in vivo

TitleIn situ photopolymerizable drug delivery matrix: Tensile property, degradation products, tissue adhesiveness, and efficacy in vivo
Authors
Issue Date2004
Citation
Transactions - 7th World Biomaterials Congress, 2004, p. 616 How to Cite?
AbstractThe assessment of interpenetrating (IPN) tensile property, degradation products, tissue adhesive strength, and efficacy of released in situ photopolymerizable drug delivery, was described. The IPNs were photocured in a mold held directly on freshly isolated rat epidermis, dermis, or latissimus dorsi muscle. IPNs exhibited an enhanced elasticity and strength when compared to glutaraldehyde-fixed gelatin hydrogels. The nature of IPN degradation products was independent of the type of gelatin backbone modification. The results show that IPNs have potential as biodegradabe/compatible, tailorable, in situ delivery matrices for therapeutic drugs and cells in wound management and tissue scaffolding.
Persistent Identifierhttp://hdl.handle.net/10722/216177

 

DC FieldValueLanguage
dc.contributor.authorKao, W. J.-
dc.contributor.authorZilinski, J. L.-
dc.contributor.authorMartinez-Diaz, G. J.-
dc.contributor.authorNelson, D.-
dc.contributor.authorWitte, R.-
dc.date.accessioned2015-08-25T10:22:13Z-
dc.date.available2015-08-25T10:22:13Z-
dc.date.issued2004-
dc.identifier.citationTransactions - 7th World Biomaterials Congress, 2004, p. 616-
dc.identifier.urihttp://hdl.handle.net/10722/216177-
dc.description.abstractThe assessment of interpenetrating (IPN) tensile property, degradation products, tissue adhesive strength, and efficacy of released in situ photopolymerizable drug delivery, was described. The IPNs were photocured in a mold held directly on freshly isolated rat epidermis, dermis, or latissimus dorsi muscle. IPNs exhibited an enhanced elasticity and strength when compared to glutaraldehyde-fixed gelatin hydrogels. The nature of IPN degradation products was independent of the type of gelatin backbone modification. The results show that IPNs have potential as biodegradabe/compatible, tailorable, in situ delivery matrices for therapeutic drugs and cells in wound management and tissue scaffolding.-
dc.languageeng-
dc.relation.ispartofTransactions - 7th World Biomaterials Congress-
dc.titleIn situ photopolymerizable drug delivery matrix: Tensile property, degradation products, tissue adhesiveness, and efficacy in vivo-
dc.typeConference_Paper-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-13844298172-
dc.identifier.spage616-
dc.identifier.epage616-

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