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Article: Mechanical and Chemical Analysis of Gelatin-Based Hydrogel Degradation

TitleMechanical and Chemical Analysis of Gelatin-Based Hydrogel Degradation
Authors
KeywordsBiomaterials
Mechanical properties
Interpenetrating networks (IPN)
Gel permeation chromatography (GPC)
Degradation
Issue Date2003
Citation
Macromolecular Chemistry and Physics, 2003, v. 204, n. 15, p. 1898-1908 How to Cite?
AbstractThe interrelated effect of environmental pH and temperature, gelatin backbone modification and content on the tensile and degradative property of interpenetrating networks (IPNs) containing gelatin and poly(ethylene glycol) diacrylate (PEGdA) was examined. Either increasing the PEGdA content or modifying the gelatin backbone with PEG-monoacetate ester and/or polyanions decreased the IPN elasticity at ambient room temperature (rt). Under an aqueous environment of varying pH levels and elevated temperature, the degradation of IPN tensile properties was further accelerated. IPNs showed an enhanced elasticity and strength when compared to glutaraldehyde-fixed gelatin hydrogels. Under an aqueous condition, IPNs showed a wider range of degradation products than hydrogels cross-linked with glutaraldehyde, as characterized with gel permeation chromatography. The nature of IPN degradation products was independent of the type of gelatin backbone modification. The presence of loaded drug, chlorohexidine digluconate, which was found to interact with PEG-monoacetate esters of the modified gelatin backbone, resulted in unique degradation products. The tensile and chemical degradation of IPNs is a complex interrelationship of the environmental condition, time, and material modification.
Persistent Identifierhttp://hdl.handle.net/10722/216170
ISSN
2015 Impact Factor: 2.495
2015 SCImago Journal Rankings: 0.955

 

DC FieldValueLanguage
dc.contributor.authorMartínez-Díaz, Gabriel J.-
dc.contributor.authorNelson, Darceé-
dc.contributor.authorCrone, Wendy C.-
dc.contributor.authorKao, Weiyuan John-
dc.date.accessioned2015-08-25T10:22:10Z-
dc.date.available2015-08-25T10:22:10Z-
dc.date.issued2003-
dc.identifier.citationMacromolecular Chemistry and Physics, 2003, v. 204, n. 15, p. 1898-1908-
dc.identifier.issn1022-1352-
dc.identifier.urihttp://hdl.handle.net/10722/216170-
dc.description.abstractThe interrelated effect of environmental pH and temperature, gelatin backbone modification and content on the tensile and degradative property of interpenetrating networks (IPNs) containing gelatin and poly(ethylene glycol) diacrylate (PEGdA) was examined. Either increasing the PEGdA content or modifying the gelatin backbone with PEG-monoacetate ester and/or polyanions decreased the IPN elasticity at ambient room temperature (rt). Under an aqueous environment of varying pH levels and elevated temperature, the degradation of IPN tensile properties was further accelerated. IPNs showed an enhanced elasticity and strength when compared to glutaraldehyde-fixed gelatin hydrogels. Under an aqueous condition, IPNs showed a wider range of degradation products than hydrogels cross-linked with glutaraldehyde, as characterized with gel permeation chromatography. The nature of IPN degradation products was independent of the type of gelatin backbone modification. The presence of loaded drug, chlorohexidine digluconate, which was found to interact with PEG-monoacetate esters of the modified gelatin backbone, resulted in unique degradation products. The tensile and chemical degradation of IPNs is a complex interrelationship of the environmental condition, time, and material modification.-
dc.languageeng-
dc.relation.ispartofMacromolecular Chemistry and Physics-
dc.subjectBiomaterials-
dc.subjectMechanical properties-
dc.subjectInterpenetrating networks (IPN)-
dc.subjectGel permeation chromatography (GPC)-
dc.subjectDegradation-
dc.titleMechanical and Chemical Analysis of Gelatin-Based Hydrogel Degradation-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1002/macp.200350042-
dc.identifier.scopuseid_2-s2.0-0242323592-
dc.identifier.volume204-
dc.identifier.issue15-
dc.identifier.spage1898-
dc.identifier.epage1908-

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