File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Multifunctional protein-based matrix for drug delivery and wound management

TitleMultifunctional protein-based matrix for drug delivery and wound management
Authors
KeywordsProtein modification
Mechanical property
Interpenetrating networks
Biomaterials
Issue Date2003
Citation
Materials Science Forum, 2003, v. 426-432, n. 4, p. 3145-3150 How to Cite?
AbstractBiological systems operate at a multi-component and hierarchical scale that requires the participation of specific cues (i.e., cells, proteins) orchestrated in a precise spatial and temporal fashion. Our objective is to establish a robust and multifunctional material construct that provides multiple growth and developmental signals to enhance, cellular function and to assist in the re-establishment of normal tissue architecture. We developed an in situ photopolymerized interpenetrating network (IPN) system that consists of (i) gelatin modified with polyanions and/or polyethyleneglycols (PEG) and (ii) PEG-diacrylate at various ratios. Immobilized and soluble factors were incorporated within the IPN to provide various biological signals in modulating cellular behavior. The effect of formulation on IPN chemicophysical properties, drug release kinetics, in vitro cell interaction thereof, and in vivo host response were quantified.
Persistent Identifierhttp://hdl.handle.net/10722/216167
ISSN
2005 Impact Factor: 0.399

 

DC FieldValueLanguage
dc.contributor.authorKao, W. J.-
dc.contributor.authorBurmania, J.-
dc.contributor.authorLi, J.-
dc.contributor.authorEinerson, N.-
dc.contributor.authorWitte, R.-
dc.contributor.authorStevens, K.-
dc.contributor.authorNelson, D.-
dc.contributor.authorMartinez-Diaz, G.-
dc.date.accessioned2015-08-25T10:22:08Z-
dc.date.available2015-08-25T10:22:08Z-
dc.date.issued2003-
dc.identifier.citationMaterials Science Forum, 2003, v. 426-432, n. 4, p. 3145-3150-
dc.identifier.issn0255-5476-
dc.identifier.urihttp://hdl.handle.net/10722/216167-
dc.description.abstractBiological systems operate at a multi-component and hierarchical scale that requires the participation of specific cues (i.e., cells, proteins) orchestrated in a precise spatial and temporal fashion. Our objective is to establish a robust and multifunctional material construct that provides multiple growth and developmental signals to enhance, cellular function and to assist in the re-establishment of normal tissue architecture. We developed an in situ photopolymerized interpenetrating network (IPN) system that consists of (i) gelatin modified with polyanions and/or polyethyleneglycols (PEG) and (ii) PEG-diacrylate at various ratios. Immobilized and soluble factors were incorporated within the IPN to provide various biological signals in modulating cellular behavior. The effect of formulation on IPN chemicophysical properties, drug release kinetics, in vitro cell interaction thereof, and in vivo host response were quantified.-
dc.languageeng-
dc.relation.ispartofMaterials Science Forum-
dc.subjectProtein modification-
dc.subjectMechanical property-
dc.subjectInterpenetrating networks-
dc.subjectBiomaterials-
dc.titleMultifunctional protein-based matrix for drug delivery and wound management-
dc.typeConference_Paper-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0037662085-
dc.identifier.volume426-432-
dc.identifier.issue4-
dc.identifier.spage3145-
dc.identifier.epage3150-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats