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Article: In vivo biocompatibility of gelatin-based hydrogels and interpenetrating networks

TitleIn vivo biocompatibility of gelatin-based hydrogels and interpenetrating networks
Authors
KeywordsSubcutaneous cage implant
Dexamethasone
Glutaraldehyde
Leukocytes
Polyethyleneglycol
Issue Date2002
Citation
Journal of Biomaterials Science, Polymer Edition, 2002, v. 13, n. 12, p. 1353-1366 How to Cite?
AbstractThe in vivo host response to two gelatin-based hydrogel systems of varying crosslinking modalities and loaded with the anti-inflammatory agent dexamethasone sodium phosphate was investigated. Either gelatin was chemically crosslinked with glutaraldehyde, or polyethyleneglycol diacrylate was photopolymerized around gelatin to form interpenetrating networks. The subcutaneous cage implant system was utilized to determine differential leukocyte concentrations in the inflammatory exudate surrounding the materials as indices for biocompatibility and drug efficacy in vivo. Most of the crosslinked gelatin-based materials, either via glutaraldehyde fixation or interpenetrating network formation, elicited stronger inflammatory responses than either of the starting materials, gelatin and polyethyleneglycol diacrylate. In general, dexamethasone delayed and intensified the inflammatory response. The loss of material mass did not correlate directly with the degree of cellular inflammatory response, but increased with longer implantation time and decreased with more extensive fixation.
Persistent Identifierhttp://hdl.handle.net/10722/216162
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.482

 

DC FieldValueLanguage
dc.contributor.authorStevens, Kelly R.-
dc.contributor.authorEinerson, Nicole J.-
dc.contributor.authorBurmania, Jeanine A.-
dc.contributor.authorKao, Weiyuan John-
dc.date.accessioned2015-08-25T10:22:06Z-
dc.date.available2015-08-25T10:22:06Z-
dc.date.issued2002-
dc.identifier.citationJournal of Biomaterials Science, Polymer Edition, 2002, v. 13, n. 12, p. 1353-1366-
dc.identifier.issn0920-5063-
dc.identifier.urihttp://hdl.handle.net/10722/216162-
dc.description.abstractThe in vivo host response to two gelatin-based hydrogel systems of varying crosslinking modalities and loaded with the anti-inflammatory agent dexamethasone sodium phosphate was investigated. Either gelatin was chemically crosslinked with glutaraldehyde, or polyethyleneglycol diacrylate was photopolymerized around gelatin to form interpenetrating networks. The subcutaneous cage implant system was utilized to determine differential leukocyte concentrations in the inflammatory exudate surrounding the materials as indices for biocompatibility and drug efficacy in vivo. Most of the crosslinked gelatin-based materials, either via glutaraldehyde fixation or interpenetrating network formation, elicited stronger inflammatory responses than either of the starting materials, gelatin and polyethyleneglycol diacrylate. In general, dexamethasone delayed and intensified the inflammatory response. The loss of material mass did not correlate directly with the degree of cellular inflammatory response, but increased with longer implantation time and decreased with more extensive fixation.-
dc.languageeng-
dc.relation.ispartofJournal of Biomaterials Science, Polymer Edition-
dc.subjectSubcutaneous cage implant-
dc.subjectDexamethasone-
dc.subjectGlutaraldehyde-
dc.subjectLeukocytes-
dc.subjectPolyethyleneglycol-
dc.titleIn vivo biocompatibility of gelatin-based hydrogels and interpenetrating networks-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1163/15685620260449741-
dc.identifier.pmid12555901-
dc.identifier.scopuseid_2-s2.0-0036962734-
dc.identifier.volume13-
dc.identifier.issue12-
dc.identifier.spage1353-
dc.identifier.epage1366-

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