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Article: Genetically predicted testosterone and electrocardiographic QT interval duration in Chinese: A Mendelian randomization analysis in the Guangzhou Biobank Cohort Study

TitleGenetically predicted testosterone and electrocardiographic QT interval duration in Chinese: A Mendelian randomization analysis in the Guangzhou Biobank Cohort Study
Authors
KeywordsMendelian randomization
Testosterone
QT interval
Issue Date2015
PublisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/
Citation
International Journal of Epidemiology, 2015, v. 44, n. 2, p. 613-620 How to Cite?
AbstractBackground QT interval prolongation, a predictor of cardiac arrhythmias, and elevated heart rate are associated with higher risk of cardiovascular mortality. Observationally testosterone is associated with shorter corrected QT interval and slower heart rate; however, the evidence is open to residual confounding and reverse causality. We examined the association of testosterone with electrocardiogram (ECG) parameters using a separate-sample instrumental variable (SSIV) estimator. Methods To minimize reverse causality, a genetic score predicting testosterone was developed in 289 young Chinese men from Hong Kong, based on a parsimonious set of single nuclear polymorphisms (rs10046, rs1008805 and rs1256031). Linear regression was used to examine the association of genetically predicted testosterone with QT interval, corrected QT interval [using the Framingham formula (QTf) and Bazett formula (QTb)] and heart rate in 4212 older (50+ years) Chinese men from the Guangzhou Biobank Cohort Study. Results Predicted testosterone was not associated with QT interval [-0.08 ms per nmol/l testosterone, 95% confidence interval (CI) -0.81 to 0.65] , QTf interval (0.40 ms per nmol/l testosterone, 95% CI -0.12 to 0.93) or heart rate (0.26 beats per minute per nmol/l testosterone, 95% CI -0.04 to 0.56), but was associated with longer QTb interval (0.66 ms per nmol/l testosterone, 95% CI 0.02 to 1.31). Conclusions Our findings do not corroborate observed protective associations of testosterone with QT interval or heart rate among men, but potentially suggest effects in the other direction. Replication in a larger sample is required.
Persistent Identifierhttp://hdl.handle.net/10722/216025
ISSN
2015 Impact Factor: 7.522
2015 SCImago Journal Rankings: 4.381

 

DC FieldValueLanguage
dc.contributor.authorZhao, J-
dc.contributor.authorJiang, C-
dc.contributor.authorLam, TH-
dc.contributor.authorLiu, B-
dc.contributor.authorCheng, KK-
dc.contributor.authorXu, L-
dc.contributor.authorLong, M-
dc.contributor.authorZhang, W-
dc.contributor.authorLeung, GM-
dc.contributor.authorSchooling, CM-
dc.date.accessioned2015-08-21T13:49:33Z-
dc.date.available2015-08-21T13:49:33Z-
dc.date.issued2015-
dc.identifier.citationInternational Journal of Epidemiology, 2015, v. 44, n. 2, p. 613-620-
dc.identifier.issn0300-5771-
dc.identifier.urihttp://hdl.handle.net/10722/216025-
dc.description.abstractBackground QT interval prolongation, a predictor of cardiac arrhythmias, and elevated heart rate are associated with higher risk of cardiovascular mortality. Observationally testosterone is associated with shorter corrected QT interval and slower heart rate; however, the evidence is open to residual confounding and reverse causality. We examined the association of testosterone with electrocardiogram (ECG) parameters using a separate-sample instrumental variable (SSIV) estimator. Methods To minimize reverse causality, a genetic score predicting testosterone was developed in 289 young Chinese men from Hong Kong, based on a parsimonious set of single nuclear polymorphisms (rs10046, rs1008805 and rs1256031). Linear regression was used to examine the association of genetically predicted testosterone with QT interval, corrected QT interval [using the Framingham formula (QTf) and Bazett formula (QTb)] and heart rate in 4212 older (50+ years) Chinese men from the Guangzhou Biobank Cohort Study. Results Predicted testosterone was not associated with QT interval [-0.08 ms per nmol/l testosterone, 95% confidence interval (CI) -0.81 to 0.65] , QTf interval (0.40 ms per nmol/l testosterone, 95% CI -0.12 to 0.93) or heart rate (0.26 beats per minute per nmol/l testosterone, 95% CI -0.04 to 0.56), but was associated with longer QTb interval (0.66 ms per nmol/l testosterone, 95% CI 0.02 to 1.31). Conclusions Our findings do not corroborate observed protective associations of testosterone with QT interval or heart rate among men, but potentially suggest effects in the other direction. Replication in a larger sample is required.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/-
dc.relation.ispartofInternational Journal of Epidemiology-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Journal of Epidemiology following peer review. The definitive publisher-authenticated version International Journal of Epidemiology, 2015, v. 44 n. 2, p. 613-620 is available online at: http://ije.oxfordjournals.org/content/44/2/613-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectMendelian randomization-
dc.subjectTestosterone-
dc.subjectQT interval-
dc.titleGenetically predicted testosterone and electrocardiographic QT interval duration in Chinese: A Mendelian randomization analysis in the Guangzhou Biobank Cohort Study-
dc.typeArticle-
dc.identifier.emailJiang, C: cqjiang@hkucc.hku.hk-
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.emailCheng, KK: chengkk@hkucc.hku.hk-
dc.identifier.emailXu, L: linxu@hku.hk-
dc.identifier.emailZhang, W: zhangws9@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hk-
dc.identifier.authorityLam, TH=rp00326-
dc.identifier.authorityXu, L=rp02030-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authoritySchooling, CM=rp00504-
dc.description.naturepostprint-
dc.identifier.doi10.1093/ije/dyu241-
dc.identifier.pmid25502105-
dc.identifier.scopuseid_2-s2.0-84936764512-
dc.identifier.hkuros247398-
dc.identifier.volume44-
dc.identifier.issue2-
dc.identifier.spage613-
dc.identifier.epage620-
dc.publisher.placeUnited Kingdom-

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