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Article: Caffeine derived platinum(II) N-heterocyclic carbene complexes with multiple anti-cancer activities

TitleCaffeine derived platinum(II) N-heterocyclic carbene complexes with multiple anti-cancer activities
Authors
Issue Date2015
PublisherElsevier. The Journal's web site is located at http://www.elsevier.com/locate/jorganchem
Citation
Journal of Organometallic Chemistry, 2015, v. 782, p. 37-41 How to Cite?
AbstractOrganometallic platinum(II) terpyridine complexes with a caffeine derived N-heterocyclic carbene (NHC) ligand were investigated as possible anti-cancer drugs in comparison to analogs, which contain N-coordinated theobromine. In general the carbene complexes displayed significantly higher biological activity than the theobromine analogs. In particular, the caffeine derived organometallic platinum(II) complex [PtII(2,2′:6′,2″-terpyridine) (1,3,7,9-tetramethylxanthine-8-ylidene)](PF6)2 (1) displayed very promising cytotoxic activity towards several cancer cell lines, and showed in-vitro anti-angiogenic effects at sub-cytotoxic concentrations. Moreover, it induced neural differentiation-like morphological changes in breast adenocarcinoma (MCF-7) cells.
Persistent Identifierhttp://hdl.handle.net/10722/215144

 

DC FieldValueLanguage
dc.contributor.authorZhang, JJ-
dc.contributor.authorChe, CM-
dc.contributor.authorOtt, I-
dc.date.accessioned2015-08-21T13:15:51Z-
dc.date.available2015-08-21T13:15:51Z-
dc.date.issued2015-
dc.identifier.citationJournal of Organometallic Chemistry, 2015, v. 782, p. 37-41-
dc.identifier.urihttp://hdl.handle.net/10722/215144-
dc.description.abstractOrganometallic platinum(II) terpyridine complexes with a caffeine derived N-heterocyclic carbene (NHC) ligand were investigated as possible anti-cancer drugs in comparison to analogs, which contain N-coordinated theobromine. In general the carbene complexes displayed significantly higher biological activity than the theobromine analogs. In particular, the caffeine derived organometallic platinum(II) complex [PtII(2,2′:6′,2″-terpyridine) (1,3,7,9-tetramethylxanthine-8-ylidene)](PF6)2 (1) displayed very promising cytotoxic activity towards several cancer cell lines, and showed in-vitro anti-angiogenic effects at sub-cytotoxic concentrations. Moreover, it induced neural differentiation-like morphological changes in breast adenocarcinoma (MCF-7) cells.-
dc.languageeng-
dc.publisherElsevier. The Journal's web site is located at http://www.elsevier.com/locate/jorganchem-
dc.relation.ispartofJournal of Organometallic Chemistry-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in [Journal title]. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI# -
dc.titleCaffeine derived platinum(II) N-heterocyclic carbene complexes with multiple anti-cancer activities-
dc.typeArticle-
dc.identifier.emailChe, CM: cmche@hku.hk-
dc.identifier.authorityChe, CM=rp00670-
dc.identifier.doi10.1016/j.jorganchem.2014.10.041-
dc.identifier.hkuros246910-
dc.identifier.volume782-
dc.identifier.spage37-
dc.identifier.epage41-
dc.publisher.placeAmsterdam, The Netherlands-

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