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Article: Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview

TitleRecent advances in ginseng as cancer therapeutics: a functional and mechanistic overview
Authors
Issue Date2015
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/npr
Citation
Natural Product Reports, 2015, v. 32, p. 256-272 How to Cite?
AbstractCancer is one of the leading causes of death worldwide. Ginseng, a key ingredient in traditional Chinese medicine, shows great promise as a new treatment option. As listed by the U.S. National Institutes of Health as a complementary and alternative medicine, its anti-cancer functions are being increasingly recognized. This review covers the mechanisms of action of ginsenosides and their metabolites, which can modulate signaling pathways associated with inflammation, oxidative stress, angiogenesis, metastasis, and stem/progenitor-like properties of cancer cells. The emerging use of structurally modified ginsenosides and recent clinical studies on the use of ginseng either alone or in combination with other herbs or Western medicines which are exploited as novel therapeutic strategies will also be explored.
Persistent Identifierhttp://hdl.handle.net/10722/215138

 

DC FieldValueLanguage
dc.contributor.authorWong, AST-
dc.contributor.authorChe, CM-
dc.contributor.authorLeung, KW-
dc.date.accessioned2015-08-21T13:15:32Z-
dc.date.available2015-08-21T13:15:32Z-
dc.date.issued2015-
dc.identifier.citationNatural Product Reports, 2015, v. 32, p. 256-272-
dc.identifier.urihttp://hdl.handle.net/10722/215138-
dc.description.abstractCancer is one of the leading causes of death worldwide. Ginseng, a key ingredient in traditional Chinese medicine, shows great promise as a new treatment option. As listed by the U.S. National Institutes of Health as a complementary and alternative medicine, its anti-cancer functions are being increasingly recognized. This review covers the mechanisms of action of ginsenosides and their metabolites, which can modulate signaling pathways associated with inflammation, oxidative stress, angiogenesis, metastasis, and stem/progenitor-like properties of cancer cells. The emerging use of structurally modified ginsenosides and recent clinical studies on the use of ginseng either alone or in combination with other herbs or Western medicines which are exploited as novel therapeutic strategies will also be explored.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/npr-
dc.relation.ispartofNatural Product Reports-
dc.titleRecent advances in ginseng as cancer therapeutics: a functional and mechanistic overview-
dc.typeArticle-
dc.identifier.emailWong, AST: awong1@hku.hk-
dc.identifier.emailChe, CM: cmche@hku.hk-
dc.identifier.authorityWong, AST=rp00805-
dc.identifier.authorityChe, CM=rp00670-
dc.identifier.authorityLeung, KW=rp01674-
dc.identifier.doi10.1039/C4NP00080C-
dc.identifier.hkuros246903-
dc.identifier.volume32-
dc.identifier.spage256-
dc.identifier.epage272-
dc.publisher.placeCambridge, UK-

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