File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Defining a ‘golden window' period and relevance of systemic inflammatory response syndrome (SIRS) in acute on chronic liver failure (ACLF) a tool for intervention and improved survival

TitleDefining a ‘golden window' period and relevance of systemic inflammatory response syndrome (SIRS) in acute on chronic liver failure (ACLF) a tool for intervention and improved survival
Authors
KeywordsMedical sciences
Endocrinology
Issue Date2015
PublisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0
Citation
The 24th Annual Conference of the Asian Pacific Association for the Study of the Liver (APASL 2015), Istanbul, Turkey, 12-15 March 2015. In Hepatology International, 2015, v. 9 n. suppl. 1, p. S4, abstract no. 1948-S5 How to Cite?
AbstractBACKGROUND AND AIMS: Systemic Inflammatory Response Syndrome (SIRS) is an early marker of sepsis and ongoing inflammation. Sepsis is the most common cause of mortality. The aim is to study the natural course of SIRS and sepsis in a hospitalized ACLF cohort without SIRS, sepsis at baseline and to define a window period for possible intervention. METHODS: Consecutive hospitalized patient of ACLF were prospectively evaluated for the development of SIRS/sepsis and associated complications till 90 days follow up, liver transplant or death. All patients received standard medical care, sepsis screening was done for initial 15 days, followed by ‘on suspicion’ screening. RESULTS: 201 patients with median age 46 yr (IQR = 38–45), male (91 %) and majority of ethanol (47 %) etiology. New onset SIRS, sepsis and septic shock at the end of first week were (77.6, 10 and 1 %) respectively. The time to development of SIRS, sepsis were 6.18 ± 1.7 and 7 days (IQR 4–7) respectively. Rate of development or resolution of SIRS 11–12 % per day. Development of SIRS associated with procalcitonin positivity (P = 0.05). Increasing no of organ failure (0, 3, 4) associated with higher incidence of SIRS (24, 87.5 and 100 % respectively, P\0.05). SIRS at D7 leads to a median survival (12 vs. 29 weeks), first week mortality (23 % vs. none, P\0.005) and 90 days mortality of (51.9 % vs. 37.8 %, P = 0.12). CONCLUSION: SIRS and its dynamicity is an important predictor of early sepsis, organ failure and survival in ACLF. Prompt use of prophylactic antibiotics with onset SIRS and rigorous septic screen during in the Golden window could improve outcome.
DescriptionConference Theme: New Horizons from East to west in Hepatology
Topic 1 - Acute on Chronic Liver Failure: no. 1948
This journal suppl. entitled: Conference Abstracts: 24th Annual Conference of APASL, March 12-15, 2015, Istanbul, Turkey
Persistent Identifierhttp://hdl.handle.net/10722/214872
ISSN
2015 Impact Factor: 1.125
2015 SCImago Journal Rankings: 0.669

 

DC FieldValueLanguage
dc.contributor.authorChoudhury, A-
dc.contributor.authorSarin, SK-
dc.contributor.authorKumar, KNC-
dc.contributor.authorVashishtha, C-
dc.contributor.authorAbbas, Z-
dc.contributor.authorAmarpurkar, D-
dc.contributor.authorButt, AS-
dc.contributor.authorChan, A-
dc.contributor.authorChawla, YK-
dc.contributor.authorDokmec, AK-
dc.contributor.authorGarg, H-
dc.contributor.authorGhazinyan, H-
dc.contributor.authorHamid, SS-
dc.contributor.authorJia, JD-
dc.contributor.authorKumar, M-
dc.contributor.authorLee, GH-
dc.contributor.authorLesmana, L-
dc.contributor.authorMahtab, M-
dc.contributor.authorMaiwa, R-
dc.contributor.authorMoreau, R-
dc.contributor.authorNing, Q-
dc.contributor.authorPamecha, V-
dc.contributor.authorPayawal, D-
dc.contributor.authorRahman, S-
dc.contributor.authorSamuel, D-
dc.contributor.authorShah, S-
dc.contributor.authorShiha, G-
dc.contributor.authorSharma, BC-
dc.contributor.authorTan, SS-
dc.contributor.authorYuen, MF-
dc.contributor.authorYokosuka, O-
dc.contributor.authorDevarbhabi, HC-
dc.contributor.authorEapen, CE-
dc.contributor.authorApasl Aclf Working Party,-
dc.date.accessioned2015-08-21T12:00:36Z-
dc.date.available2015-08-21T12:00:36Z-
dc.date.issued2015-
dc.identifier.citationThe 24th Annual Conference of the Asian Pacific Association for the Study of the Liver (APASL 2015), Istanbul, Turkey, 12-15 March 2015. In Hepatology International, 2015, v. 9 n. suppl. 1, p. S4, abstract no. 1948-S5-
dc.identifier.issn1936-0533-
dc.identifier.urihttp://hdl.handle.net/10722/214872-
dc.descriptionConference Theme: New Horizons from East to west in Hepatology-
dc.descriptionTopic 1 - Acute on Chronic Liver Failure: no. 1948-
dc.descriptionThis journal suppl. entitled: Conference Abstracts: 24th Annual Conference of APASL, March 12-15, 2015, Istanbul, Turkey-
dc.description.abstractBACKGROUND AND AIMS: Systemic Inflammatory Response Syndrome (SIRS) is an early marker of sepsis and ongoing inflammation. Sepsis is the most common cause of mortality. The aim is to study the natural course of SIRS and sepsis in a hospitalized ACLF cohort without SIRS, sepsis at baseline and to define a window period for possible intervention. METHODS: Consecutive hospitalized patient of ACLF were prospectively evaluated for the development of SIRS/sepsis and associated complications till 90 days follow up, liver transplant or death. All patients received standard medical care, sepsis screening was done for initial 15 days, followed by ‘on suspicion’ screening. RESULTS: 201 patients with median age 46 yr (IQR = 38–45), male (91 %) and majority of ethanol (47 %) etiology. New onset SIRS, sepsis and septic shock at the end of first week were (77.6, 10 and 1 %) respectively. The time to development of SIRS, sepsis were 6.18 ± 1.7 and 7 days (IQR 4–7) respectively. Rate of development or resolution of SIRS 11–12 % per day. Development of SIRS associated with procalcitonin positivity (P = 0.05). Increasing no of organ failure (0, 3, 4) associated with higher incidence of SIRS (24, 87.5 and 100 % respectively, P\0.05). SIRS at D7 leads to a median survival (12 vs. 29 weeks), first week mortality (23 % vs. none, P\0.005) and 90 days mortality of (51.9 % vs. 37.8 %, P = 0.12). CONCLUSION: SIRS and its dynamicity is an important predictor of early sepsis, organ failure and survival in ACLF. Prompt use of prophylactic antibiotics with onset SIRS and rigorous septic screen during in the Golden window could improve outcome.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0-
dc.relation.ispartofHepatology International-
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1007/s12072-015-9609-1-
dc.subjectMedical sciences-
dc.subjectEndocrinology-
dc.titleDefining a ‘golden window' period and relevance of systemic inflammatory response syndrome (SIRS) in acute on chronic liver failure (ACLF) a tool for intervention and improved survival-
dc.typeConference_Paper-
dc.identifier.emailChan, A: acchan@hku.hk-
dc.identifier.emailYuen, MF: mfyuen@hku.hk-
dc.identifier.authorityChan, A=rp00310-
dc.identifier.authorityYuen, MF=rp00479-
dc.identifier.doi10.1007/s12072-015-9609-1-
dc.identifier.hkuros248061-
dc.identifier.volume9-
dc.identifier.issuesuppl. 1-
dc.identifier.spageS4, abstract no. 1948-
dc.identifier.epageS5-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats