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Article: A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome

TitleA Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome
Authors
Issue Date2015
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2015, v. 5, p. 10179 How to Cite?
AbstractA novel protein, designated as DOI, isolated from the Chinese yam (Dioscorea opposita Thunb.) could be the first protein drug for the treatment of menopausal syndrome and an alternative to hormone replacement therapy (HRT), which is known to have undesirable side effects. DOI is an acid- and thermo-stable protein with a distinctive N-terminal sequence Gly-Ile-Gly-Lys-Ile-Thr-Thr-Tyr-Trp-Gly-Gln-Tyr-Ser-Asp-Glu-Pro-Ser-Leu-Thr-Glu. DOI was found to stimulate estradiol biosynthesis in rat ovarian granulosa cells; induce estradiol and progesterone secretion in 16- to 18-month-old female Sprague Dawley rats by upregulating expressions of follicle-stimulating hormone receptor and ovarian aromatase; counteract the progression of osteoporosis and augment bone mineral density; and improve cognitive functioning by upregulating protein expressions of brain-derived neurotrophic factor and TrkB receptors in the prefrontal cortex. Furthermore, DOI did not stimulate the proliferation of breast cancer and ovarian cancer cells, which suggest it could be a more efficacious and safer alternative to HRT.
Persistent Identifierhttp://hdl.handle.net/10722/214438
ISSN
2015 Impact Factor: 5.228
2015 SCImago Journal Rankings: 2.073

 

DC FieldValueLanguage
dc.contributor.authorWong, KL-
dc.contributor.authorLai, YM-
dc.contributor.authorLi, KW-
dc.contributor.authorLee, CKF-
dc.contributor.authorNg, TB-
dc.contributor.authorCheung, HP-
dc.contributor.authorZhang, Y-
dc.contributor.authorLao, L-
dc.contributor.authorWong, RNS-
dc.contributor.authorShaw, PC-
dc.contributor.authorWong, JH-
dc.contributor.authorZhang, Z-
dc.contributor.authorLam, JKW-
dc.contributor.authorYe, W-
dc.contributor.authorSze, CWS-
dc.date.accessioned2015-08-21T11:25:24Z-
dc.date.available2015-08-21T11:25:24Z-
dc.date.issued2015-
dc.identifier.citationScientific Reports, 2015, v. 5, p. 10179-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/214438-
dc.description.abstractA novel protein, designated as DOI, isolated from the Chinese yam (Dioscorea opposita Thunb.) could be the first protein drug for the treatment of menopausal syndrome and an alternative to hormone replacement therapy (HRT), which is known to have undesirable side effects. DOI is an acid- and thermo-stable protein with a distinctive N-terminal sequence Gly-Ile-Gly-Lys-Ile-Thr-Thr-Tyr-Trp-Gly-Gln-Tyr-Ser-Asp-Glu-Pro-Ser-Leu-Thr-Glu. DOI was found to stimulate estradiol biosynthesis in rat ovarian granulosa cells; induce estradiol and progesterone secretion in 16- to 18-month-old female Sprague Dawley rats by upregulating expressions of follicle-stimulating hormone receptor and ovarian aromatase; counteract the progression of osteoporosis and augment bone mineral density; and improve cognitive functioning by upregulating protein expressions of brain-derived neurotrophic factor and TrkB receptors in the prefrontal cortex. Furthermore, DOI did not stimulate the proliferation of breast cancer and ovarian cancer cells, which suggest it could be a more efficacious and safer alternative to HRT.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.titleA Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome-
dc.typeArticle-
dc.identifier.emailLee, CKF: ckflee@hku.hk-
dc.identifier.emailZhang, Y: ybzhang@hku.hk-
dc.identifier.emailLao, L: lxlao1@hku.hk-
dc.identifier.emailZhang, Z: zhangzj@hkucc.hku.hk-
dc.identifier.emailLam, JKW: jkwlam@hku.hk-
dc.identifier.emailSze, CWS: stephens@hku.hk-
dc.identifier.authorityLee, CKF=rp00458-
dc.identifier.authorityZhang, Y=rp01410-
dc.identifier.authorityLao, L=rp01784-
dc.identifier.authorityZhang, Z=rp01297-
dc.identifier.authorityLam, JKW=rp01346-
dc.identifier.authoritySze, CWS=rp00514-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/srep10179-
dc.identifier.pmid26160710-
dc.identifier.hkuros246344-
dc.identifier.volume5-
dc.identifier.spage10179-
dc.identifier.epage10179-
dc.publisher.placeUnited Kingdom-

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