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Article: Current perspectives on the role of TRAMP in nuclear RNA surveillance and quality control

TitleCurrent perspectives on the role of TRAMP in nuclear RNA surveillance and quality control
Authors
Issue Date2015
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/research-and-reports-in-biochemistry-journal
Citation
Research and Reports in Biochemistry, 2015, v. 5, p. 111-117 How to Cite?
AbstractThe TRAMP complex assists the nuclear exosome to degrade a broad range of ribonucleic acid (RNA) substrates by increasing both exoribonucleolytic activity and substrate specificity. However, how the interactions between the TRAMP subunits and the components of the nuclear exosome regulate their functions in RNA degradation and substrate specificity remain unclear. This review aims to provide a summary of the recent findings on the role of the TRAMP complex in nuclear RNA degradation. The new insights from recent structural biological studies are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/214333
ISSN

 

DC FieldValueLanguage
dc.contributor.authorPan, K-
dc.contributor.authorHuang, Z-
dc.contributor.authorLee, JTH-
dc.contributor.authorWong, CM-
dc.date.accessioned2015-08-21T11:16:08Z-
dc.date.available2015-08-21T11:16:08Z-
dc.date.issued2015-
dc.identifier.citationResearch and Reports in Biochemistry, 2015, v. 5, p. 111-117-
dc.identifier.issn2230-3154-
dc.identifier.urihttp://hdl.handle.net/10722/214333-
dc.description.abstractThe TRAMP complex assists the nuclear exosome to degrade a broad range of ribonucleic acid (RNA) substrates by increasing both exoribonucleolytic activity and substrate specificity. However, how the interactions between the TRAMP subunits and the components of the nuclear exosome regulate their functions in RNA degradation and substrate specificity remain unclear. This review aims to provide a summary of the recent findings on the role of the TRAMP complex in nuclear RNA degradation. The new insights from recent structural biological studies are discussed.-
dc.languageeng-
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/research-and-reports-in-biochemistry-journal-
dc.relation.ispartofResearch and Reports in Biochemistry-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleCurrent perspectives on the role of TRAMP in nuclear RNA surveillance and quality control-
dc.typeArticle-
dc.identifier.emailPan, K: pankewu@hku.hk-
dc.identifier.emailWong, CM: wispwong@hku.hk-
dc.identifier.authorityWong, CM=rp01489-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2147/RRBC.S58509-
dc.identifier.hkuros246892-
dc.identifier.volume5-
dc.identifier.spage111-
dc.identifier.epage117-
dc.publisher.placeUnited Kingdom-

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