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Article: Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing

TitleCoupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing
Authors
Issue Date2015
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal of Molecular Sciences, 2015, v. 16 n. 3, p. 5682-5696 How to Cite?
AbstractA processing is a tightly regulated and highly complex pathway which includes transcription, splicing, editing, transportation, translation and degradation. It has been well-documented that splicing of RNA polymerase II medicated nascent transcripts occurs co-transcriptionally and is functionally coupled to other RNA processing. Recently, increasing experimental evidence indicated that pre-mRNA splicing influences RNA degradation and vice versa. In this review, we summarized the recent findings demonstrating the coupling of these two processes. In addition, we highlighted the importance of splicing in the production of intronic miRNA and circular RNAs, and hence the discovery of the novel mechanisms in the regulation of gene expression.
Persistent Identifierhttp://hdl.handle.net/10722/214332
ISSN
2015 Impact Factor: 3.257
2015 SCImago Journal Rankings: 1.160
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorPan, K-
dc.contributor.authorLee, JTH-
dc.contributor.authorHuang, Z-
dc.contributor.authorWong, CM-
dc.date.accessioned2015-08-21T11:15:57Z-
dc.date.available2015-08-21T11:15:57Z-
dc.date.issued2015-
dc.identifier.citationInternational Journal of Molecular Sciences, 2015, v. 16 n. 3, p. 5682-5696-
dc.identifier.issn1422-0067-
dc.identifier.urihttp://hdl.handle.net/10722/214332-
dc.description.abstractA processing is a tightly regulated and highly complex pathway which includes transcription, splicing, editing, transportation, translation and degradation. It has been well-documented that splicing of RNA polymerase II medicated nascent transcripts occurs co-transcriptionally and is functionally coupled to other RNA processing. Recently, increasing experimental evidence indicated that pre-mRNA splicing influences RNA degradation and vice versa. In this review, we summarized the recent findings demonstrating the coupling of these two processes. In addition, we highlighted the importance of splicing in the production of intronic miRNA and circular RNAs, and hence the discovery of the novel mechanisms in the regulation of gene expression.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleCoupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing-
dc.typeArticle-
dc.identifier.emailPan, K: pankewu@hku.hk-
dc.identifier.emailWong, CM: wispwong@hku.hk-
dc.identifier.authorityWong, CM=rp01489-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms16035682-
dc.identifier.pmid25768347-
dc.identifier.pmcidPMC4394499-
dc.identifier.hkuros246891-
dc.identifier.volume16-
dc.identifier.issue3-
dc.identifier.spage5682-
dc.identifier.epage5696-
dc.publisher.placeSwitzerland-

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