File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Adiponectin attenuates liver fibrosis by inducing nitric oxide production of hepatic stellate cells

TitleAdiponectin attenuates liver fibrosis by inducing nitric oxide production of hepatic stellate cells
Authors
Issue Date2015
PublisherSpringer. The Journal's web site is located at http://www.springer.com/biomed/molecular/journal/109
Citation
Journal of Molecular Medicine, 2015 How to Cite?
AbstractAdiponectin protects against liver fibrosis, but the mechanisms have not been fully elucidated. Here, we showed that adiponectin upregulated inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) and protein expression in hepatic non-parenchymal cells, particularly in hepatic stellate cells (HSCs), and increased nitric oxide (NO2-/NO3-) concentration in HSC-conditioned medium. Adiponectin attenuated HSC proliferation and migration but promoted apoptosis in a NO-dependent manner. More advanced liver fibrosis with decreased iNOS/NO levels was observed in adiponectin knockout mice comparing to wide-type mice when administered with CCI4 while NO donor supplementation rescued the phenotype. Further experiments demonstrated that adiponectin-induced iNOS/NO system activation is mediated through adipoR2-AMPK-JNK/Erk1/2-NF-κB signaling. These data suggest that adiponectin inhibits HSC function, further limiting the development of liver fibrosis at least in part through adiponectin-induced NO release. Therefore, adiponectin-mediated NO signaling may be a novel target for the treatment of liver fibrosis. KEY MESSAGES: • Adiponectin activates HSC iNOS/NO and SEC eNOS/NO systems. • Adiponectin inhibits HSC proliferation and migration but promotes its apoptosis. • Adiponectin inhibits CCL4-induced liver fibrosis by modulation of liver iNOS/NO. • Adiponectin stimulates HSC iNOS/NO via adipoR2-AMPK-JNK/ErK1/2-NF-κB pathway.
Persistent Identifierhttp://hdl.handle.net/10722/214327
ISSN
2015 Impact Factor: 4.855
2015 SCImago Journal Rankings: 2.165

 

DC FieldValueLanguage
dc.contributor.authorDong, Z-
dc.contributor.authorSu, L-
dc.contributor.authorEsmaili, S-
dc.contributor.authorIseli, TJ-
dc.contributor.authorRamezani-Moghadam, M-
dc.contributor.authorHu, L-
dc.contributor.authorXu, A-
dc.contributor.authorGeorge, J-
dc.contributor.authorWang, J-
dc.date.accessioned2015-08-21T11:15:00Z-
dc.date.available2015-08-21T11:15:00Z-
dc.date.issued2015-
dc.identifier.citationJournal of Molecular Medicine, 2015-
dc.identifier.issn0946-2716-
dc.identifier.urihttp://hdl.handle.net/10722/214327-
dc.description.abstractAdiponectin protects against liver fibrosis, but the mechanisms have not been fully elucidated. Here, we showed that adiponectin upregulated inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) and protein expression in hepatic non-parenchymal cells, particularly in hepatic stellate cells (HSCs), and increased nitric oxide (NO2-/NO3-) concentration in HSC-conditioned medium. Adiponectin attenuated HSC proliferation and migration but promoted apoptosis in a NO-dependent manner. More advanced liver fibrosis with decreased iNOS/NO levels was observed in adiponectin knockout mice comparing to wide-type mice when administered with CCI4 while NO donor supplementation rescued the phenotype. Further experiments demonstrated that adiponectin-induced iNOS/NO system activation is mediated through adipoR2-AMPK-JNK/Erk1/2-NF-κB signaling. These data suggest that adiponectin inhibits HSC function, further limiting the development of liver fibrosis at least in part through adiponectin-induced NO release. Therefore, adiponectin-mediated NO signaling may be a novel target for the treatment of liver fibrosis. KEY MESSAGES: • Adiponectin activates HSC iNOS/NO and SEC eNOS/NO systems. • Adiponectin inhibits HSC proliferation and migration but promotes its apoptosis. • Adiponectin inhibits CCL4-induced liver fibrosis by modulation of liver iNOS/NO. • Adiponectin stimulates HSC iNOS/NO via adipoR2-AMPK-JNK/ErK1/2-NF-κB pathway.-
dc.languageeng-
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/biomed/molecular/journal/109-
dc.relation.ispartofJournal of Molecular Medicine-
dc.titleAdiponectin attenuates liver fibrosis by inducing nitric oxide production of hepatic stellate cells-
dc.typeArticle-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.authorityXu, A=rp00485-
dc.identifier.doi10.1007/s00109-015-1313-z-
dc.identifier.hkuros246872-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats