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Conference Paper: Aerobic exercise and yoga hold promises for improving neurocognition and symptom in early psychosis

TitleAerobic exercise and yoga hold promises for improving neurocognition and symptom in early psychosis
Authors
Issue Date2015
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
The 15th International Congress on Schizophrenia Research (ICOSR 2015), The Broadmoor, CO., 28 March-1 April 2015. In Schizophrenia Bulletin, 2015, v. 41 suppl. 1, p. S320 How to Cite?
AbstractBACKGROUND: The current study aims to explore the effects of aerobic exercise and mind-body exercise (yoga) on cognitive function and clinical symptom in female patients with early psychosis. The potential neuromechanism underlying the clinical consequences was also investigated. METHODS: Female patients (n=120) diagnosed with schizophrenia spectrum disorders and psychotic disorder were recruited from outpatient clinic. They were randomized into integrated yoga therapy group, aerobic exercise programme group, and waiting list as the control group. Both interventions were held three times weekly for 12 weeks. Neuro-cognition and clinical symptom were compared between baseline and 12 weeks among the three groups using repeated measures ANOVA . Structural MRI data was collected in 60 patients and analysed using FreeSurfer V5.1 and Qdec V1.4. RESULTS: Both yoga and aerobic exercise improved verbal memory (p<0.01) and working memory (p<0.01) with moderate to large effect sizes compared to control group. Additionally, yoga group showed enhanced attention and visual-motor coordination (p<0.05). Both yoga and aerobic exercise reduced overall symptom (p<0.05) and depressive symptom (p<0.05) after 12 weeks. Furthermore, yoga increased cortical thickness in post-central gyrus (p<0.001) and aerobic exercise increased cortical thickness in superior frontal gyrus (p<0.001). CONCLUSION: Both types of exercise improved cognition in early psychosis patients, with yoga having a superior effect on attention and visual-motor coordination. Observed increments in the cortical thicknesses may indicate improved neurogenesis. The present study indicates possible interventions for cognitive impairments in the patients with early psychosis, which are non-invasive and mostly safe. This project was supported by the Small Project Funding, The University of Hong Kong (Reference No. 201007176229), and General Research Fund (GRF), Hong Kong Research Grants Council (Reference No. C00240 / 762412). ID: 2087194
DescriptionSession - Therapeutics, Treatment Trials
This free journal suppl. entitled: Abstracts for the 15th International Congress on Schizophrenia Research
Persistent Identifierhttp://hdl.handle.net/10722/214264
ISSN
2015 Impact Factor: 7.757
2015 SCImago Journal Rankings: 4.051

 

DC FieldValueLanguage
dc.contributor.authorLin, JJX-
dc.contributor.authorLee, EHM-
dc.contributor.authorChang, WC-
dc.contributor.authorChan, SKW-
dc.contributor.authorTse, M-
dc.contributor.authorPhong, PL-
dc.contributor.authorChan, CLW-
dc.contributor.authorHoner, W-
dc.contributor.authorChen, EYH-
dc.date.accessioned2015-08-21T11:07:29Z-
dc.date.available2015-08-21T11:07:29Z-
dc.date.issued2015-
dc.identifier.citationThe 15th International Congress on Schizophrenia Research (ICOSR 2015), The Broadmoor, CO., 28 March-1 April 2015. In Schizophrenia Bulletin, 2015, v. 41 suppl. 1, p. S320-
dc.identifier.issn0586-7614-
dc.identifier.urihttp://hdl.handle.net/10722/214264-
dc.descriptionSession - Therapeutics, Treatment Trials-
dc.descriptionThis free journal suppl. entitled: Abstracts for the 15th International Congress on Schizophrenia Research-
dc.description.abstractBACKGROUND: The current study aims to explore the effects of aerobic exercise and mind-body exercise (yoga) on cognitive function and clinical symptom in female patients with early psychosis. The potential neuromechanism underlying the clinical consequences was also investigated. METHODS: Female patients (n=120) diagnosed with schizophrenia spectrum disorders and psychotic disorder were recruited from outpatient clinic. They were randomized into integrated yoga therapy group, aerobic exercise programme group, and waiting list as the control group. Both interventions were held three times weekly for 12 weeks. Neuro-cognition and clinical symptom were compared between baseline and 12 weeks among the three groups using repeated measures ANOVA . Structural MRI data was collected in 60 patients and analysed using FreeSurfer V5.1 and Qdec V1.4. RESULTS: Both yoga and aerobic exercise improved verbal memory (p<0.01) and working memory (p<0.01) with moderate to large effect sizes compared to control group. Additionally, yoga group showed enhanced attention and visual-motor coordination (p<0.05). Both yoga and aerobic exercise reduced overall symptom (p<0.05) and depressive symptom (p<0.05) after 12 weeks. Furthermore, yoga increased cortical thickness in post-central gyrus (p<0.001) and aerobic exercise increased cortical thickness in superior frontal gyrus (p<0.001). CONCLUSION: Both types of exercise improved cognition in early psychosis patients, with yoga having a superior effect on attention and visual-motor coordination. Observed increments in the cortical thicknesses may indicate improved neurogenesis. The present study indicates possible interventions for cognitive impairments in the patients with early psychosis, which are non-invasive and mostly safe. This project was supported by the Small Project Funding, The University of Hong Kong (Reference No. 201007176229), and General Research Fund (GRF), Hong Kong Research Grants Council (Reference No. C00240 / 762412). ID: 2087194-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/-
dc.relation.ispartofSchizophrenia Bulletin-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.titleAerobic exercise and yoga hold promises for improving neurocognition and symptom in early psychosis-
dc.typeConference_Paper-
dc.identifier.emailLin, JJX: jxlin@hku.hk-
dc.identifier.emailLee, EHM: edwinlhm@hku.hk-
dc.identifier.emailChang, WC: changwc@hku.hk-
dc.identifier.emailChan, SKW: kwsherry@hku.hk-
dc.identifier.emailChan, CLW: cecichan@hku.hk-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.authorityLee, EHM=rp01575-
dc.identifier.authorityChang, WC=rp01465-
dc.identifier.authorityChan, SKW=rp00539-
dc.identifier.authorityChan, CLW=rp00579-
dc.identifier.authorityChen, EYH=rp00392-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/schbul/sbv010-
dc.identifier.hkuros249149-
dc.identifier.volume41-
dc.identifier.issuesuppl. 1-
dc.identifier.spageS320-
dc.identifier.epageS320-
dc.publisher.placeUnited Kingdom-

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