File Download
  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: Baseline clinical and functional correlates of first-episode psychosis patients presenting with Predominantly Negative Symptoms to the JCEP Project

TitleBaseline clinical and functional correlates of first-episode psychosis patients presenting with Predominantly Negative Symptoms to the JCEP Project
Authors
Issue Date2014
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://easap.asia/index.htm
Citation
The 2014 Regional Congress of the World Psychiatric Association (WPA), Hong Kong, 12-14 December 2014. In East Asian Archives of Psychiatry, 2014, v. 24 n. 4 suppl., p. 101-102, abstract G12 How to Cite?
AbstractOBJECTIVES: Negative symptoms are considered as the core feature of psychotic disorders. Prior research have found associations between negative symptoms and poorer functional outcomes. Relatively few studies have focused on the implications of negative symptoms on the early course of psychotic illnesses. This study aimed to examine first-episode patients in this respect. METHODS: A total of 360 patients aged 26 to 55 years presenting with first-episode psychosis (DSM-IV schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, brief psychotic disorder, psychosis not-otherwise-specified, or manic episodes with psychotic features) to the Jockey Club Early Psychosis (JCEP) project in Hong Kong were recruited. Patients were classified as either having or not having predominantly negative symptoms (PNS), which were defined as the presence of clinically significant negative symptoms (i.e. one or more global scores on the subscales of SANS on affect, alogia, apathy, or anhedonia-asociality were >2) with an exclusion of depression, extra-pyramidal signs, and clinically significant positive symptoms. Data on premorbid functioning and baseline clinical and cognitive profiles were obtained. RESULTS: Overall, 39 (10.8%) patients had PNS at study entry. The difference in overall premorbid functioning was insignificant. However, patients with PNS exhibited significantly poorer premorbid adjustment in the social domain (Premorbid Adjustment Scale social domain: t = 1.992, p < 0.05). These patients also showed significantly poorer insight (PANSS: χ²(1, N=360) = 11.513, p = 0.001) and global functioning (SOFAS rating: t = –2.057, p < 0.05; Role Functioning Scale: t = –3.209, p < 0.05). There was no significant difference between patients with and without PNS in demographics, duration of untreated psychosis, and cognitive performance. CONCLUSION: First-episode patients with PNS exhibited specific characteristics with respect to global functioning, insight and premorbid adjustment in the social domain. Follow-up studies should examine the predictive capacity of PNS on the development of persistent negative symptoms and the longitudinal relationships between negative symptoms and other social and cognitive correlates.
DescriptionCongress Theme: Yin and Yang of Mental Health in Asia - Balancing Polarities
Category G – Schizophrenia and Psychotic Disorders: no. G12
Persistent Identifierhttp://hdl.handle.net/10722/214256
ISSN
2015 SCImago Journal Rankings: 0.331

 

DC FieldValueLanguage
dc.contributor.authorChan, SI-
dc.contributor.authorChang, WC-
dc.contributor.authorXu, JQ-
dc.contributor.authorHui, LM-
dc.contributor.authorLin, JX-
dc.contributor.authorChan, KW-
dc.contributor.authorLee, EHM-
dc.contributor.authorChen, EYH-
dc.date.accessioned2015-08-21T11:04:38Z-
dc.date.available2015-08-21T11:04:38Z-
dc.date.issued2014-
dc.identifier.citationThe 2014 Regional Congress of the World Psychiatric Association (WPA), Hong Kong, 12-14 December 2014. In East Asian Archives of Psychiatry, 2014, v. 24 n. 4 suppl., p. 101-102, abstract G12-
dc.identifier.issn2078-9947-
dc.identifier.urihttp://hdl.handle.net/10722/214256-
dc.descriptionCongress Theme: Yin and Yang of Mental Health in Asia - Balancing Polarities-
dc.descriptionCategory G – Schizophrenia and Psychotic Disorders: no. G12-
dc.description.abstractOBJECTIVES: Negative symptoms are considered as the core feature of psychotic disorders. Prior research have found associations between negative symptoms and poorer functional outcomes. Relatively few studies have focused on the implications of negative symptoms on the early course of psychotic illnesses. This study aimed to examine first-episode patients in this respect. METHODS: A total of 360 patients aged 26 to 55 years presenting with first-episode psychosis (DSM-IV schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, brief psychotic disorder, psychosis not-otherwise-specified, or manic episodes with psychotic features) to the Jockey Club Early Psychosis (JCEP) project in Hong Kong were recruited. Patients were classified as either having or not having predominantly negative symptoms (PNS), which were defined as the presence of clinically significant negative symptoms (i.e. one or more global scores on the subscales of SANS on affect, alogia, apathy, or anhedonia-asociality were >2) with an exclusion of depression, extra-pyramidal signs, and clinically significant positive symptoms. Data on premorbid functioning and baseline clinical and cognitive profiles were obtained. RESULTS: Overall, 39 (10.8%) patients had PNS at study entry. The difference in overall premorbid functioning was insignificant. However, patients with PNS exhibited significantly poorer premorbid adjustment in the social domain (Premorbid Adjustment Scale social domain: t = 1.992, p < 0.05). These patients also showed significantly poorer insight (PANSS: χ²(1, N=360) = 11.513, p = 0.001) and global functioning (SOFAS rating: t = –2.057, p < 0.05; Role Functioning Scale: t = –3.209, p < 0.05). There was no significant difference between patients with and without PNS in demographics, duration of untreated psychosis, and cognitive performance. CONCLUSION: First-episode patients with PNS exhibited specific characteristics with respect to global functioning, insight and premorbid adjustment in the social domain. Follow-up studies should examine the predictive capacity of PNS on the development of persistent negative symptoms and the longitudinal relationships between negative symptoms and other social and cognitive correlates.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://easap.asia/index.htm-
dc.relation.ispartofEast Asian Archives of Psychiatry-
dc.relation.ispartof東亞精神科學志-
dc.rightsEast Asian Archives of Psychiatry. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleBaseline clinical and functional correlates of first-episode psychosis patients presenting with Predominantly Negative Symptoms to the JCEP Project-
dc.typeConference_Paper-
dc.identifier.emailChang, WC: changwc@hku.hk-
dc.identifier.emailHui, LM: christyh@hkucc.hku.hk-
dc.identifier.emailLin, JX: jxlin@hku.hk-
dc.identifier.emailChan, KW: kwsherry@hku.hk-
dc.identifier.emailLee, EHM: edwinlhm@hku.hk-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.authorityChang, WC=rp01465-
dc.identifier.authorityHui, LM=rp01993-
dc.identifier.authorityChan, KW=rp00539-
dc.identifier.authorityLee, EHM=rp01575-
dc.identifier.authorityChen, EYH=rp00392-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros249134-
dc.identifier.volume24-
dc.identifier.issue4 suppl.-
dc.identifier.spage101, abstract G12-
dc.identifier.epage102-
dc.publisher.placeHong Kong-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats