File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Predictors of treatment resistant schizophrenia-spectrum disorder: 10-year retrospective study of first-episode psychosis

TitlePredictors of treatment resistant schizophrenia-spectrum disorder: 10-year retrospective study of first-episode psychosis
Authors
KeywordsMedical sciences
Psychiatry and neurology
Issue Date2014
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1751-7885&site=1
Citation
The 9th International Conference on Early Psychosis (IEPA 2014), Tokyo, Japan, 17-19 November 2014. In Early Intervention in Psychiatry, 2014, v. 8 suppl. S1, p. 78, abstract no. A56 How to Cite?
AbstractBACKGROUND: Schizophrenia is a serious mental illness that affects approximately 1% of the general population. While pharmacological treatment has been the main intervention for patients, evidence has suggested that around 20–30% of patients do not respond to antipsychotic medication and are considered as treatment resistant. The present study aimed to explore the prevalence and patterns of treatment resistant schizophrenia, and predictive factors associated with its development. METHODS: Seven hundred patients with first-episode psychosis (Mage: 34.92, SD: 3.74) presented to the Early Intervention Service in Hong Kong from January 1998 August 2003 were studied. Socio-demographics, duration of untreated psychosis, age of first presentation and medication history were collected via systematic medical file review. Treatment resistant status was defined as ever been treated with Clozapine. RESULTS: Of all 700 patients studied, 69 (9.9%) are treatment resistant. Of the 69 patients, 2 (0.3%) were recorded dead. Logistic regression analysis revealed that age of first presentation (p = 0.001), number of relapse during the first three years (p < 0.001) and duration of atypical antipsychotics prescription over the initial three years (p < 0.05) reliably predicted clozapine status. CONCLUSION: The preliminary results showed that younger age of first onset, more number of relapse and longer duration of atypical antipsychotics prescription over the initial three years are associated with increased risk of developing treatment-resistant. These suggested the contribution of both neurodevelopmental and neurodegenerative factors. Further studies should focus on detail understanding of the role of these factors in the longitudinal progression of the illness.
DescriptionConference Theme: To the New Horizon
Poster Session A: Basic Neuroscience - Psychopharmacology: no. A56
This free Journal suppl. entitled: Special Issue: 9th International Conference on Early Psychosis – To the New Horizon ... Tokyo Japan
Persistent Identifierhttp://hdl.handle.net/10722/214241
ISSN
2015 Impact Factor: 2.889
2015 SCImago Journal Rankings: 1.071

 

DC FieldValueLanguage
dc.contributor.authorChan, SKW-
dc.contributor.authorChan, WY-
dc.contributor.authorHui, CLM-
dc.contributor.authorChang, WC-
dc.contributor.authorLee, EHM-
dc.contributor.authorChen, EYH-
dc.date.accessioned2015-08-21T10:59:34Z-
dc.date.available2015-08-21T10:59:34Z-
dc.date.issued2014-
dc.identifier.citationThe 9th International Conference on Early Psychosis (IEPA 2014), Tokyo, Japan, 17-19 November 2014. In Early Intervention in Psychiatry, 2014, v. 8 suppl. S1, p. 78, abstract no. A56-
dc.identifier.issn1751-7885-
dc.identifier.urihttp://hdl.handle.net/10722/214241-
dc.descriptionConference Theme: To the New Horizon-
dc.descriptionPoster Session A: Basic Neuroscience - Psychopharmacology: no. A56-
dc.descriptionThis free Journal suppl. entitled: Special Issue: 9th International Conference on Early Psychosis – To the New Horizon ... Tokyo Japan-
dc.description.abstractBACKGROUND: Schizophrenia is a serious mental illness that affects approximately 1% of the general population. While pharmacological treatment has been the main intervention for patients, evidence has suggested that around 20–30% of patients do not respond to antipsychotic medication and are considered as treatment resistant. The present study aimed to explore the prevalence and patterns of treatment resistant schizophrenia, and predictive factors associated with its development. METHODS: Seven hundred patients with first-episode psychosis (Mage: 34.92, SD: 3.74) presented to the Early Intervention Service in Hong Kong from January 1998 August 2003 were studied. Socio-demographics, duration of untreated psychosis, age of first presentation and medication history were collected via systematic medical file review. Treatment resistant status was defined as ever been treated with Clozapine. RESULTS: Of all 700 patients studied, 69 (9.9%) are treatment resistant. Of the 69 patients, 2 (0.3%) were recorded dead. Logistic regression analysis revealed that age of first presentation (p = 0.001), number of relapse during the first three years (p < 0.001) and duration of atypical antipsychotics prescription over the initial three years (p < 0.05) reliably predicted clozapine status. CONCLUSION: The preliminary results showed that younger age of first onset, more number of relapse and longer duration of atypical antipsychotics prescription over the initial three years are associated with increased risk of developing treatment-resistant. These suggested the contribution of both neurodevelopmental and neurodegenerative factors. Further studies should focus on detail understanding of the role of these factors in the longitudinal progression of the illness.-
dc.languageeng-
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1751-7885&site=1-
dc.relation.ispartofEarly Intervention in Psychiatry-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectMedical sciences-
dc.subjectPsychiatry and neurology-
dc.titlePredictors of treatment resistant schizophrenia-spectrum disorder: 10-year retrospective study of first-episode psychosis-
dc.typeConference_Paper-
dc.identifier.emailChan, SKW: kwsherry@hku.hk-
dc.identifier.emailHui, CLM: christyh@hkucc.hku.hk-
dc.identifier.emailChang, WC: changwc@hku.hk-
dc.identifier.emailLee, EHM: edwinlhm@hku.hk-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.authorityChan, SKW=rp00539-
dc.identifier.authorityHui, CLM=rp01993-
dc.identifier.authorityChang, WC=rp01465-
dc.identifier.authorityLee, EHM=rp01575-
dc.identifier.authorityChen, EYH=rp00392-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/eip.12199-
dc.identifier.hkuros249098-
dc.identifier.volume8-
dc.identifier.issuesuppl. S1-
dc.identifier.spage78, abstract no. A56-
dc.identifier.epage78, abstract no. A56-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats