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Article: Nasopharyngeal carcinoma in situ: Two cases of an emerging diagnostic entity

TitleNasopharyngeal carcinoma in situ: Two cases of an emerging diagnostic entity
Authors
KeywordsNasopharyngeal carcinoma in situ
In situ hybridization Epstein-Barr virus-encoded RNA
Preinvasive lesions
Issue Date1998
Citation
Cancer, 1998, v. 83, n. 6, p. 1069-1073 How to Cite?
AbstractBACKGROUND. The association of Epstein-Barr virus (EBV) with the oncogenesis of nasopharyngeal carcinoma (NPC) is well established. Latent infection by EBV with clonal proliferation has also been demonstrated in preinvasive lesions of NPC. In situ hybridization for EBV-encoded RNA (ISH EBER) now serves as an ancillary test in the definitive diagnosis of these lesions. METHODS. Two cases of nasopharyngeal carcinoma in situ (NPCIS) are presented in this study. Their biopsies were studied by ordinary light microscopy, the ISH EBER technique, and immunostaining for bcl-2. Tissue samples from 100 high risk subjects negative for NPC and NPCIS, who served as controls, were also studied using the ISH EBER technique. RESULTS. NPCIS was characterized by abnormal light microscopic appearance as well as positive staining by the ISH EBER technique; these features were not observed in samples from the 100 high risk subjects. Immunostaining for bcl-2 protein was positive but less specific. Postradiotherapy biopsies of the two patients were negative for NPCIS. CONCLUSIONS. With the help of the ISH EBER technique, the diagnosis of NPCIS is now possible in routine surgical pathology. As this entity is rare, it is necessary to have a high degree of suspicion when evaluating biopsies from high risk individuals. Radiotherapy for patients with NPCIS is justified in view of the risk of cancer progression and the possibility of a coexisting invasive carcinoma.
Persistent Identifierhttp://hdl.handle.net/10722/213912
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188

 

DC FieldValueLanguage
dc.contributor.authorCheung, Florence-
dc.contributor.authorPang, Siu Wah-
dc.contributor.authorHioe, Fei-
dc.contributor.authorCheung, Kin Nam-
dc.contributor.authorLee, Anne-
dc.contributor.authorYau, Tsz Kok-
dc.date.accessioned2015-08-19T13:41:11Z-
dc.date.available2015-08-19T13:41:11Z-
dc.date.issued1998-
dc.identifier.citationCancer, 1998, v. 83, n. 6, p. 1069-1073-
dc.identifier.issn0008-543X-
dc.identifier.urihttp://hdl.handle.net/10722/213912-
dc.description.abstractBACKGROUND. The association of Epstein-Barr virus (EBV) with the oncogenesis of nasopharyngeal carcinoma (NPC) is well established. Latent infection by EBV with clonal proliferation has also been demonstrated in preinvasive lesions of NPC. In situ hybridization for EBV-encoded RNA (ISH EBER) now serves as an ancillary test in the definitive diagnosis of these lesions. METHODS. Two cases of nasopharyngeal carcinoma in situ (NPCIS) are presented in this study. Their biopsies were studied by ordinary light microscopy, the ISH EBER technique, and immunostaining for bcl-2. Tissue samples from 100 high risk subjects negative for NPC and NPCIS, who served as controls, were also studied using the ISH EBER technique. RESULTS. NPCIS was characterized by abnormal light microscopic appearance as well as positive staining by the ISH EBER technique; these features were not observed in samples from the 100 high risk subjects. Immunostaining for bcl-2 protein was positive but less specific. Postradiotherapy biopsies of the two patients were negative for NPCIS. CONCLUSIONS. With the help of the ISH EBER technique, the diagnosis of NPCIS is now possible in routine surgical pathology. As this entity is rare, it is necessary to have a high degree of suspicion when evaluating biopsies from high risk individuals. Radiotherapy for patients with NPCIS is justified in view of the risk of cancer progression and the possibility of a coexisting invasive carcinoma.-
dc.languageeng-
dc.relation.ispartofCancer-
dc.subjectNasopharyngeal carcinoma in situ-
dc.subjectIn situ hybridization Epstein-Barr virus-encoded RNA-
dc.subjectPreinvasive lesions-
dc.titleNasopharyngeal carcinoma in situ: Two cases of an emerging diagnostic entity-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1097-0142(19980915)83:6<1069::AID-CNCR3>3.0.CO;2-3-
dc.identifier.pmid9740069-
dc.identifier.scopuseid_2-s2.0-3543029800-
dc.identifier.hkuros266422-
dc.identifier.volume83-
dc.identifier.issue6-
dc.identifier.spage1069-
dc.identifier.epage1073-

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