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Article: Staging of nasopharyngeal carcinoma: From Ho's to the new UICC system

TitleStaging of nasopharyngeal carcinoma: From Ho's to the new UICC system
Authors
Issue Date1999
Citation
International Journal of Cancer, 1999, v. 84, n. 2, p. 179-187 How to Cite?
AbstractThe independent significance of different tumor factors in 4,514 patients with undifferentiated or non-keratinizing carcinoma of the nasopharynx irradiated at the Queen Elizabeth Hospital during 1976-1985 were analyzed retrospectively. Multivariate analyses showed that the most significant primary factors included cranial nerve palsy, erosion of base of skull and oropharynx. For tumors within the nasopharynx, there was no difference in survival between those with involvement of 1 site vs. more than 1 sites. Patients with cranial nerve palsy had significantly worse prognosis than those with bony erosion alone. Although the nodal characteristics (size, level of extension, fixation, laterality and multiplicity) were inter- related, their independent impact all reached statistical significance. However, the criteria used currently could be simplified: laterality should be revised to unilateral vs. bilateral, level to upper-mid vs. lower neck, and size to ≤6 cm vs. >6 cm. Grouping of N2 together with N3 into Stage IV was inappropriate as the former had significantly better prognosis. Our findings, together with review of the publications, provided clinical data for developing the current UICC staging system for nasopharyngeal carcinoma. Such major revision resulted not only in better distinction of hazards, but also more even distribution of cases between different stages.
Persistent Identifierhttp://hdl.handle.net/10722/213881
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657

 

DC FieldValueLanguage
dc.contributor.authorLee, Anne W M-
dc.contributor.authorFoo, William-
dc.contributor.authorLaw, Stephen C K-
dc.contributor.authorPoon, Y. F.-
dc.contributor.authorO, S. K.-
dc.contributor.authorTung, Stewart Y.-
dc.contributor.authorSze, W. M.-
dc.contributor.authorChappell, Rick-
dc.contributor.authorLau, W. H.-
dc.contributor.authorHo, John H C-
dc.date.accessioned2015-08-19T13:41:04Z-
dc.date.available2015-08-19T13:41:04Z-
dc.date.issued1999-
dc.identifier.citationInternational Journal of Cancer, 1999, v. 84, n. 2, p. 179-187-
dc.identifier.issn0020-7136-
dc.identifier.urihttp://hdl.handle.net/10722/213881-
dc.description.abstractThe independent significance of different tumor factors in 4,514 patients with undifferentiated or non-keratinizing carcinoma of the nasopharynx irradiated at the Queen Elizabeth Hospital during 1976-1985 were analyzed retrospectively. Multivariate analyses showed that the most significant primary factors included cranial nerve palsy, erosion of base of skull and oropharynx. For tumors within the nasopharynx, there was no difference in survival between those with involvement of 1 site vs. more than 1 sites. Patients with cranial nerve palsy had significantly worse prognosis than those with bony erosion alone. Although the nodal characteristics (size, level of extension, fixation, laterality and multiplicity) were inter- related, their independent impact all reached statistical significance. However, the criteria used currently could be simplified: laterality should be revised to unilateral vs. bilateral, level to upper-mid vs. lower neck, and size to ≤6 cm vs. >6 cm. Grouping of N2 together with N3 into Stage IV was inappropriate as the former had significantly better prognosis. Our findings, together with review of the publications, provided clinical data for developing the current UICC staging system for nasopharyngeal carcinoma. Such major revision resulted not only in better distinction of hazards, but also more even distribution of cases between different stages.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Cancer-
dc.titleStaging of nasopharyngeal carcinoma: From Ho's to the new UICC system-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1097-0215(19990420)84:2<179::AID-IJC15>3.0.CO;2-6-
dc.identifier.pmid10096252-
dc.identifier.scopuseid_2-s2.0-0033014779-
dc.identifier.hkuros265880-
dc.identifier.volume84-
dc.identifier.issue2-
dc.identifier.spage179-
dc.identifier.epage187-

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