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Article: Recommendation for a contouring method and atlas of organs at risk in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy

TitleRecommendation for a contouring method and atlas of organs at risk in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy
Authors
KeywordsNasopharyngeal carcinoma
Intensity modulated radiotherapy
Atlas
Organs at risk
Issue Date2014
Citation
Radiotherapy and Oncology, 2014, v. 110, n. 3, p. 390-397 How to Cite?
AbstractBackground and purpose To recommend contouring methods and atlas of organs at risk (OARs) for nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy, in order to help reach a consensus on interpretations of OARs delineation. Methods and materials Two to four contouring methods for the middle ear, inner ear, temporal lobe, parotid gland and spinal cord were identified via systematic literature review; their volumes and dosimetric parameters were compared in 41 patients. Areas under the receiver operating characteristic curves for temporal lobe contouring were compared in 21 patients with unilateral temporal lobe necrosis (TLN). Results Various contouring methods for the temporal lobe, middle ear, inner ear, parotid gland and spinal cord lead to different volumes and dosimetric parameters (P < 0.05). For TLN, D1 of PRV was the most relevant dosimetric parameter and 64 Gy was the critical point. We suggest contouring for the temporal lobe, middle ear, inner ear, parotid gland and spinal cord. A CT-MRI fusion atlas comprising 33 OARs was developed. Conclusions Different dosimetric parameters may hinder the dosimetric research. The present recommendation and atlas, may help reach a consensus on subjective interpretation of OARs delineation to reduce inter-institutional differences in NPC patients. © 2013 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/213864
ISSN
2015 Impact Factor: 4.817
2015 SCImago Journal Rankings: 2.654

 

DC FieldValueLanguage
dc.contributor.authorSun, Ying-
dc.contributor.authorYu, Xiao Li-
dc.contributor.authorLuo, Wei-
dc.contributor.authorLee, Anne W M-
dc.contributor.authorWee, Joseph Tien Seng-
dc.contributor.authorLee, Nancy-
dc.contributor.authorZhou, Guan Qun-
dc.contributor.authorTang, Ling Long-
dc.contributor.authorTao, Chang Juan-
dc.contributor.authorGuo, Rui-
dc.contributor.authorMao, Yan Ping-
dc.contributor.authorZhang, Rong-
dc.contributor.authorGuo, Ying-
dc.contributor.authorMa, Jun-
dc.date.accessioned2015-08-19T13:41:00Z-
dc.date.available2015-08-19T13:41:00Z-
dc.date.issued2014-
dc.identifier.citationRadiotherapy and Oncology, 2014, v. 110, n. 3, p. 390-397-
dc.identifier.issn0167-8140-
dc.identifier.urihttp://hdl.handle.net/10722/213864-
dc.description.abstractBackground and purpose To recommend contouring methods and atlas of organs at risk (OARs) for nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy, in order to help reach a consensus on interpretations of OARs delineation. Methods and materials Two to four contouring methods for the middle ear, inner ear, temporal lobe, parotid gland and spinal cord were identified via systematic literature review; their volumes and dosimetric parameters were compared in 41 patients. Areas under the receiver operating characteristic curves for temporal lobe contouring were compared in 21 patients with unilateral temporal lobe necrosis (TLN). Results Various contouring methods for the temporal lobe, middle ear, inner ear, parotid gland and spinal cord lead to different volumes and dosimetric parameters (P < 0.05). For TLN, D1 of PRV was the most relevant dosimetric parameter and 64 Gy was the critical point. We suggest contouring for the temporal lobe, middle ear, inner ear, parotid gland and spinal cord. A CT-MRI fusion atlas comprising 33 OARs was developed. Conclusions Different dosimetric parameters may hinder the dosimetric research. The present recommendation and atlas, may help reach a consensus on subjective interpretation of OARs delineation to reduce inter-institutional differences in NPC patients. © 2013 Elsevier Ireland Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofRadiotherapy and Oncology-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectNasopharyngeal carcinoma-
dc.subjectIntensity modulated radiotherapy-
dc.subjectAtlas-
dc.subjectOrgans at risk-
dc.titleRecommendation for a contouring method and atlas of organs at risk in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.radonc.2013.10.035-
dc.identifier.pmid24721546-
dc.identifier.scopuseid_2-s2.0-84899553019-
dc.identifier.hkuros266380-
dc.identifier.volume110-
dc.identifier.issue3-
dc.identifier.spage390-
dc.identifier.epage397-
dc.identifier.eissn1879-0887-

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