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Article: T1 nasopharyngeal carcinoma: The effect of waiting time on tumor control

TitleT1 nasopharyngeal carcinoma: The effect of waiting time on tumor control
Authors
KeywordsNasopharyngeal carcinoma
Probability of tumor control
Unperturbed tumor growth
Waiting time
Issue Date1994
Citation
International Journal of Radiation Oncology - Biology - Physics, 1994, v. 30, n. 5, p. 1111-1117 How to Cite?
AbstractPurpose: To study the effect of unperturbed tumor growth on the control of nasopharyngeal carcinoma. Methods and Materials: This is a retrospective analysis of 290 patients with T1Na0-3M0 disease (Ho's classification) treated by the same technique and dose schedule to the nasopharyngeal region. The median interval from diagnosis to commencement of irradiation was 26 days (range: 8-68 days). Cox proportional hazards analyses were performed to study the independent effect of waiting time on the probability of failure at various sites. Actuarial failure-free survival of patients with delay < 22 days, 22-28 days and > 28 days were also compared to illustrate the clinical observation. Results: Both tests showed that waiting time had no significant impact on local failure: The N-stage stratified hazard ratio was 0.985 per day, and the 10-year local failure-free survival for the three groups was 76%, 80%, and 82%, respectively. A similar result was obtained for nodal control in patients with our scheduled neck irradiation. Although the p value of all tests failed to reach statistical significance, the N-stage stratified hazard ratio for distant failure was 1.020 per day, and the corresponding metastasis-free survival in patients with N2-3 disease was 70%, 65%, and 52%, respectively. For node-negative patients without elective neck irradiation, the hazard ratio was 1.019 per day, with the corresponding regional failure-free rates at 57%, 62%, and 33%, respectively. Conclusion: Delay in initiation of treatment to the primary target (within the range observed) did not affect the control rate at irradiated sites, but there was a trend (though statistically insignificant) towards increase in failures at untreated sites that were clinically too serious to be ignored. © 1994.
Persistent Identifierhttp://hdl.handle.net/10722/213854
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274

 

DC FieldValueLanguage
dc.contributor.authorLee, Anne W M-
dc.contributor.authorChan, David K K-
dc.contributor.authorFowler, Jack F.-
dc.contributor.authorPooh, Y. F.-
dc.contributor.authorLaw, Stephen C K-
dc.contributor.authorFoo, William-
dc.contributor.authorO, S. K.-
dc.contributor.authorTung, Stewart Y.-
dc.contributor.authorCheung, Fred K.-
dc.contributor.authorHo, John H C-
dc.contributor.authorChappell, Rick-
dc.date.accessioned2015-08-19T13:40:58Z-
dc.date.available2015-08-19T13:40:58Z-
dc.date.issued1994-
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 1994, v. 30, n. 5, p. 1111-1117-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/213854-
dc.description.abstractPurpose: To study the effect of unperturbed tumor growth on the control of nasopharyngeal carcinoma. Methods and Materials: This is a retrospective analysis of 290 patients with T1Na0-3M0 disease (Ho's classification) treated by the same technique and dose schedule to the nasopharyngeal region. The median interval from diagnosis to commencement of irradiation was 26 days (range: 8-68 days). Cox proportional hazards analyses were performed to study the independent effect of waiting time on the probability of failure at various sites. Actuarial failure-free survival of patients with delay < 22 days, 22-28 days and > 28 days were also compared to illustrate the clinical observation. Results: Both tests showed that waiting time had no significant impact on local failure: The N-stage stratified hazard ratio was 0.985 per day, and the 10-year local failure-free survival for the three groups was 76%, 80%, and 82%, respectively. A similar result was obtained for nodal control in patients with our scheduled neck irradiation. Although the p value of all tests failed to reach statistical significance, the N-stage stratified hazard ratio for distant failure was 1.020 per day, and the corresponding metastasis-free survival in patients with N2-3 disease was 70%, 65%, and 52%, respectively. For node-negative patients without elective neck irradiation, the hazard ratio was 1.019 per day, with the corresponding regional failure-free rates at 57%, 62%, and 33%, respectively. Conclusion: Delay in initiation of treatment to the primary target (within the range observed) did not affect the control rate at irradiated sites, but there was a trend (though statistically insignificant) towards increase in failures at untreated sites that were clinically too serious to be ignored. © 1994.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physics-
dc.subjectNasopharyngeal carcinoma-
dc.subjectProbability of tumor control-
dc.subjectUnperturbed tumor growth-
dc.subjectWaiting time-
dc.titleT1 nasopharyngeal carcinoma: The effect of waiting time on tumor control-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0360-3016(94)90317-4-
dc.identifier.pmid7961019-
dc.identifier.scopuseid_2-s2.0-0028170952-
dc.identifier.hkuros265836-
dc.identifier.volume30-
dc.identifier.issue5-
dc.identifier.spage1111-
dc.identifier.epage1117-

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