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Article: Follicular dendritic cell tumors of the oral cavity

TitleFollicular dendritic cell tumors of the oral cavity
Authors
Issue Date1994
Citation
American Journal of Surgical Pathology, 1994, v. 18, n. 2, p. 148-157 How to Cite?
AbstractFollicular dendritic cell tumors are uncommon, and all the reported cases have occurred as primary lymph node tumors. We report two cases in the oral cavity, one in the soft palate and one in the tonsil. The tumors were characterized by sheets, whorls, and storiform arrays of spindly and syncytial-appearing cells with oval nuclei, fine chromatin, distinct nucleoli, and occasional nuclear pseudoinclusions. Multinucleated forms were present and were prominent in one case. An unusual feature was the presence of irregular pseudovascular spaces, which could raise a concern for vascular neoplasm. Because the tumors showed cohesive growth and a sharp interface with the fibrous stroma, they could also be mistaken for carcinoma, sarcoma, or melanoma. After radiation therapy, the palatal tumor showed a greater degree of nuclear pleomorphism, numerous nuclear pseudoinclusions, and striking nuclear grooving and foldings, mimicking interdigitating reticulum cell tumors. The diagnosis in both cases was confirmed by immunoreactivity with CD21 and CD35 and by ultrastructural demonstration of interdigitating cell processes with desmosomes. Both tumors also showed unexpected immunoreactivity with muscle-specific actin. Follicular dendritic cell tumor merits wider recognition of its possible extranodal occurrence as well as its full morphological spectrum in order to better define its behavior.
Persistent Identifierhttp://hdl.handle.net/10722/213853
ISSN
2015 Impact Factor: 4.951
2015 SCImago Journal Rankings: 2.393

 

DC FieldValueLanguage
dc.contributor.authorChan, J. K C-
dc.contributor.authorTsang, W. Y W-
dc.contributor.authorNg, C. S.-
dc.contributor.authorTang, S. K.-
dc.contributor.authorYu, H. C.-
dc.contributor.authorLee, A. W M-
dc.date.accessioned2015-08-19T13:40:57Z-
dc.date.available2015-08-19T13:40:57Z-
dc.date.issued1994-
dc.identifier.citationAmerican Journal of Surgical Pathology, 1994, v. 18, n. 2, p. 148-157-
dc.identifier.issn0147-5185-
dc.identifier.urihttp://hdl.handle.net/10722/213853-
dc.description.abstractFollicular dendritic cell tumors are uncommon, and all the reported cases have occurred as primary lymph node tumors. We report two cases in the oral cavity, one in the soft palate and one in the tonsil. The tumors were characterized by sheets, whorls, and storiform arrays of spindly and syncytial-appearing cells with oval nuclei, fine chromatin, distinct nucleoli, and occasional nuclear pseudoinclusions. Multinucleated forms were present and were prominent in one case. An unusual feature was the presence of irregular pseudovascular spaces, which could raise a concern for vascular neoplasm. Because the tumors showed cohesive growth and a sharp interface with the fibrous stroma, they could also be mistaken for carcinoma, sarcoma, or melanoma. After radiation therapy, the palatal tumor showed a greater degree of nuclear pleomorphism, numerous nuclear pseudoinclusions, and striking nuclear grooving and foldings, mimicking interdigitating reticulum cell tumors. The diagnosis in both cases was confirmed by immunoreactivity with CD21 and CD35 and by ultrastructural demonstration of interdigitating cell processes with desmosomes. Both tumors also showed unexpected immunoreactivity with muscle-specific actin. Follicular dendritic cell tumor merits wider recognition of its possible extranodal occurrence as well as its full morphological spectrum in order to better define its behavior.-
dc.languageeng-
dc.relation.ispartofAmerican Journal of Surgical Pathology-
dc.titleFollicular dendritic cell tumors of the oral cavity-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.pmid8291653-
dc.identifier.scopuseid_2-s2.0-0028125814-
dc.identifier.hkuros265803-
dc.identifier.volume18-
dc.identifier.issue2-
dc.identifier.spage148-
dc.identifier.epage157-

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