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Article: Retrospective analysis of patients with nasopharyngeal carcinoma treated during 1976-1985: Survival after local recurrence

TitleRetrospective analysis of patients with nasopharyngeal carcinoma treated during 1976-1985: Survival after local recurrence
Authors
KeywordsRecurrent nasopharyngeal carcinoma
Long-term local control and survival
Late radiation-induced complications
Associated regional/distant failures
Aggressive reirradiation
Issue Date1993
Citation
International Journal of Radiation Oncology - Biology - Physics, 1993, v. 26, n. 5, p. 773-782 How to Cite?
AbstractPurpose: To study the value of re-irradiation, the overall survival and pattern of failures for patients with nasopharyngeal recurrence. Methods and Materials: All the 891 patients with local recurrence following radiotherapy for nasopharyngeal carcinoma during 1976-1981 were retrospectively analyzed. Only 70% of them had local failure alone at the time of detection, and the T-stage distribution (by Ho's system) was 31% rT1, 16% rT2, 51% rT3, and 1% rT?. Seven hundred and six (79%) patients had been reirradiated with various techniques and doses. Among those who failed, 50 had further irradiation. Results: The overall 5- and 10-year actuarial cancer-specific survival rates were 14% and 9%, respectively. Patients with rT3 disease had the worst prognosis. Successful local salvage was achieved in 32% of those re-irradiated (26% of the whole series). The highest control rate was achieved by those treated with external radiotherapy to 60 Gy (equivalent) or above. Only 8 50 patients responded to the third course of radiotherapy. The cumulative incidence of late post-reirradiation sequelae was 24%, and the treatment mortality rate 1.8%. Besides local failure, 54% had regional relapse and/or distant metastasis. Thus, only 16% of recurrent patients were totally disease-free at final assessment. Conclusion: The overall prognosis for patients with nasopharyngeal recurrence was grave. High dose re-irradiation could achieve successful local salvage in a substantial number of patients with early recurrence, but late complications did occur. Furthermore, high incidence of failure at other sites was observed. © 1993.
Persistent Identifierhttp://hdl.handle.net/10722/213850
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274

 

DC FieldValueLanguage
dc.contributor.authorLee, Anne W M-
dc.contributor.authorLaw, Stephen C K-
dc.contributor.authorFoo, William-
dc.contributor.authorPooh, Y. F.-
dc.contributor.authorCheung, Fred K.-
dc.contributor.authorChan, David K K-
dc.contributor.authorTung, Stewart Y.-
dc.contributor.authorThaw, Myo-
dc.contributor.authorHo, John H C-
dc.date.accessioned2015-08-19T13:40:57Z-
dc.date.available2015-08-19T13:40:57Z-
dc.date.issued1993-
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 1993, v. 26, n. 5, p. 773-782-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/213850-
dc.description.abstractPurpose: To study the value of re-irradiation, the overall survival and pattern of failures for patients with nasopharyngeal recurrence. Methods and Materials: All the 891 patients with local recurrence following radiotherapy for nasopharyngeal carcinoma during 1976-1981 were retrospectively analyzed. Only 70% of them had local failure alone at the time of detection, and the T-stage distribution (by Ho's system) was 31% rT1, 16% rT2, 51% rT3, and 1% rT?. Seven hundred and six (79%) patients had been reirradiated with various techniques and doses. Among those who failed, 50 had further irradiation. Results: The overall 5- and 10-year actuarial cancer-specific survival rates were 14% and 9%, respectively. Patients with rT3 disease had the worst prognosis. Successful local salvage was achieved in 32% of those re-irradiated (26% of the whole series). The highest control rate was achieved by those treated with external radiotherapy to 60 Gy (equivalent) or above. Only 8 50 patients responded to the third course of radiotherapy. The cumulative incidence of late post-reirradiation sequelae was 24%, and the treatment mortality rate 1.8%. Besides local failure, 54% had regional relapse and/or distant metastasis. Thus, only 16% of recurrent patients were totally disease-free at final assessment. Conclusion: The overall prognosis for patients with nasopharyngeal recurrence was grave. High dose re-irradiation could achieve successful local salvage in a substantial number of patients with early recurrence, but late complications did occur. Furthermore, high incidence of failure at other sites was observed. © 1993.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physics-
dc.subjectRecurrent nasopharyngeal carcinoma-
dc.subjectLong-term local control and survival-
dc.subjectLate radiation-induced complications-
dc.subjectAssociated regional/distant failures-
dc.subjectAggressive reirradiation-
dc.titleRetrospective analysis of patients with nasopharyngeal carcinoma treated during 1976-1985: Survival after local recurrence-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0360-3016(93)90491-D-
dc.identifier.pmid8344845-
dc.identifier.scopuseid_2-s2.0-0027203745-
dc.identifier.hkuros265788-
dc.identifier.volume26-
dc.identifier.issue5-
dc.identifier.spage773-
dc.identifier.epage782-

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