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Article: High prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients

TitleHigh prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients
Authors
Issue Date2015
PublisherSociety for General Microbiology. The Journal's web site is located at http://jmm.sgmjournals.org
Citation
Journal of Medical Microbiology, 2015, v. 64 n. 3, p. 243-247 How to Cite?
AbstractPrevious work on the subclones within Escherichia coli ST131 predominantly involved isolates from Western countries. This study assessed the prevalence and antimicrobial resistance attributed to this clonal group. A total of 340 consecutive, non-duplicated urinary E. coli isolates originating from four clinical laboratories in Hong Kong in 2013 were tested. ST131 prevalence among the total isolates was 18.5 % (63/340) and was higher among inpatient isolates (23.0 %) than outpatient isolates (11.8 %, P<0.001), and higher among isolates from patients aged ≥65 years than from patients aged 18–50 years and 51–64 years (25.4 vs 3.4 and 4.0 %, respectively, P<0.001). Of the 63 ST131 isolates, 43 (68.3 %) isolates belonged to the H30 subclone, whereas the remaining isolates belonged to H41 (n = 17), H54 (n = 2) and H22 (n = 1). All H30 isolates were ciprofloxacin-resistant, of which 18.6 % (8/43) belonged to the H30-Rx subclone. Twenty-six (41.3 %) ST131 isolates were ESBL-producers, of which 19 had bla CTX-M-14 (12 non-H30-Rx, two H30-Rx and five H41), six had bla CTX-M-15 (five non-H30-Rx and one H30-Rx) and one was bla CTX-M-negative (H30). In conclusion, ST131 accounts for a large share of the antimicrobial-resistant E. coli isolates from geriatric patients. Unlike previous reports, ESBL-producing ST131 strains mainly belonged to non-H30-Rx rather than the H30-Rx subclone, with bla CTX-M-14 as the dominant enzyme type.
Persistent Identifierhttp://hdl.handle.net/10722/213730
ISSN
2015 Impact Factor: 2.269
2015 SCImago Journal Rankings: 1.060
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, PL-
dc.contributor.authorChu, YPS-
dc.contributor.authorLo, WU-
dc.contributor.authorChow, KH-
dc.contributor.authorLaw, PYT-
dc.contributor.authorTse, CWS-
dc.contributor.authorNg, TK-
dc.contributor.authorCheng, VCC-
dc.contributor.authorQue, TL-
dc.date.accessioned2015-08-14T03:33:23Z-
dc.date.available2015-08-14T03:33:23Z-
dc.date.issued2015-
dc.identifier.citationJournal of Medical Microbiology, 2015, v. 64 n. 3, p. 243-247-
dc.identifier.issn0022-2615-
dc.identifier.urihttp://hdl.handle.net/10722/213730-
dc.description.abstractPrevious work on the subclones within Escherichia coli ST131 predominantly involved isolates from Western countries. This study assessed the prevalence and antimicrobial resistance attributed to this clonal group. A total of 340 consecutive, non-duplicated urinary E. coli isolates originating from four clinical laboratories in Hong Kong in 2013 were tested. ST131 prevalence among the total isolates was 18.5 % (63/340) and was higher among inpatient isolates (23.0 %) than outpatient isolates (11.8 %, P<0.001), and higher among isolates from patients aged ≥65 years than from patients aged 18–50 years and 51–64 years (25.4 vs 3.4 and 4.0 %, respectively, P<0.001). Of the 63 ST131 isolates, 43 (68.3 %) isolates belonged to the H30 subclone, whereas the remaining isolates belonged to H41 (n = 17), H54 (n = 2) and H22 (n = 1). All H30 isolates were ciprofloxacin-resistant, of which 18.6 % (8/43) belonged to the H30-Rx subclone. Twenty-six (41.3 %) ST131 isolates were ESBL-producers, of which 19 had bla CTX-M-14 (12 non-H30-Rx, two H30-Rx and five H41), six had bla CTX-M-15 (five non-H30-Rx and one H30-Rx) and one was bla CTX-M-negative (H30). In conclusion, ST131 accounts for a large share of the antimicrobial-resistant E. coli isolates from geriatric patients. Unlike previous reports, ESBL-producing ST131 strains mainly belonged to non-H30-Rx rather than the H30-Rx subclone, with bla CTX-M-14 as the dominant enzyme type.-
dc.languageeng-
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://jmm.sgmjournals.org-
dc.relation.ispartofJournal of Medical Microbiology-
dc.rightsJournal of Medical Microbiology. Copyright © Society for General Microbiology.-
dc.rightsThis is an author manuscript that has been accepted for publication in Journal of Medical Microbiology, copyright Society for General Microbiology, but has not been copy-edited, formatted or proofed. Cite this article as appearing in Journal of Medical Microbiology. This version of the manuscript may not be duplicated or reproduced, other than for personal use or within the rule of 'Fair Use of Copyrighted Materials' (section 17, Title 17, US Code), without permission from the copyright owner, Society for General Microbiology. The Society for General Microbiology disclaims any responsibility or liability for errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final copy-edited, published article, which is the version of record, can be found at http://jmm.sgmjournals.org, and is freely available without a subscription-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleHigh prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients-
dc.typeArticle-
dc.identifier.emailHo, PL: plho@hkucc.hku.hk-
dc.identifier.emailLo, WU: stephlo@hku.hk-
dc.identifier.emailChow, KH: khchowb@hku.hk-
dc.identifier.emailCheng, VCC: vcccheng@hkucc.hku.hk-
dc.identifier.authorityHo, PL=rp00406-
dc.identifier.authorityChow, KH=rp00370-
dc.description.naturepostprint-
dc.identifier.doi10.1099/jmm.0.000012-
dc.identifier.pmid25587081-
dc.identifier.scopuseid_2-s2.0-84923649687-
dc.identifier.hkuros246369-
dc.identifier.volume64-
dc.identifier.issue3-
dc.identifier.spage243-
dc.identifier.epage247-
dc.identifier.isiWOS:000355787600007-
dc.publisher.placeUnited Kingdom-

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