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Conference Paper: Deletion of SIRT1 in perivascular adipose tissue accelerates obesity-induced endothelial dysfunction

TitleDeletion of SIRT1 in perivascular adipose tissue accelerates obesity-induced endothelial dysfunction
Authors
Issue Date2015
PublisherThe University of Hong Kong.
Citation
The 2015 ASCEPT-BPS Joint Scientific Meeting, The University of Hong Kong, Hong Kong, 19-21 May 2015. In Poster Abstracts, 2015, p. 22, abstract no. 507 How to Cite?
AbstractINTRODUCTION: Perivascular adipose tissue (PVAT) exhibits brown adipose features and its dysfunction is implicated in cardiovascular diseases. SIRT1 is key to adipocyte phenotypes and metabolism. AIMS: In the present study, we aim to investigate the role of SIRT1 within PVAT in modulating obesity-evoked endothelial dysfunction. Methods. Wild type (WT) and adipocyte-specific SIRT1 knockout mice (AKO) were fed with standard chow or westernized diet for 12 weeks. Endothelium-dependent relaxation (EDR) in aortic rings with or without PVAT was assessed by wire myograph. DHE staining was …
DescriptionConference Theme: Tomorrow’s medicines: pharmacology, patients and populations
Persistent Identifierhttp://hdl.handle.net/10722/213680

 

DC FieldValueLanguage
dc.contributor.authorGu, P-
dc.contributor.authorHui, HX-
dc.contributor.authorVanhoutte, PM-
dc.contributor.authorLam, KSL-
dc.contributor.authorXu, A-
dc.date.accessioned2015-08-11T07:47:50Z-
dc.date.available2015-08-11T07:47:50Z-
dc.date.issued2015-
dc.identifier.citationThe 2015 ASCEPT-BPS Joint Scientific Meeting, The University of Hong Kong, Hong Kong, 19-21 May 2015. In Poster Abstracts, 2015, p. 22, abstract no. 507-
dc.identifier.urihttp://hdl.handle.net/10722/213680-
dc.descriptionConference Theme: Tomorrow’s medicines: pharmacology, patients and populations-
dc.description.abstractINTRODUCTION: Perivascular adipose tissue (PVAT) exhibits brown adipose features and its dysfunction is implicated in cardiovascular diseases. SIRT1 is key to adipocyte phenotypes and metabolism. AIMS: In the present study, we aim to investigate the role of SIRT1 within PVAT in modulating obesity-evoked endothelial dysfunction. Methods. Wild type (WT) and adipocyte-specific SIRT1 knockout mice (AKO) were fed with standard chow or westernized diet for 12 weeks. Endothelium-dependent relaxation (EDR) in aortic rings with or without PVAT was assessed by wire myograph. DHE staining was …-
dc.languageeng-
dc.publisherThe University of Hong Kong.-
dc.relation.ispartofASCEPT-BPS Joint Scientific Meeting 2015-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleDeletion of SIRT1 in perivascular adipose tissue accelerates obesity-induced endothelial dysfunction-
dc.typeConference_Paper-
dc.identifier.emailGu, P: ping1976@hku.hk-
dc.identifier.emailHui, HX: hannahui@hkucc.hku.hk-
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.authorityVanhoutte, PM=rp00238-
dc.identifier.authorityLam, KSL=rp00343-
dc.identifier.authorityXu, A=rp00485-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros247633-
dc.identifier.spage22, abstract no. 507-
dc.identifier.epage22, abstract no. 507-
dc.publisher.placeHong Kong-

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