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Conference Paper: Analysis of keratinocytes stiffness after desmosome disruption using Atomic Force Microscopy based nanomanipulation

TitleAnalysis of keratinocytes stiffness after desmosome disruption using Atomic Force Microscopy based nanomanipulation
Authors
KeywordsAFM
Cell stiffness
Nanomanipulation
Desmosome
Issue Date2009
Citation
2009 9th IEEE Conference on Nanotechnology, IEEE NANO 2009, 2009, p. 640-643 How to Cite?
AbstractDesmosomes are cell-cell junctions that provide mechanical strength for cells and maintain integrity of tissues in animal skins and hearts. Disruption of the desmosome like in some autoimmune diseases will therefore change the mechanical property of the anchoring cells and causing blistering. In the paper, we used Atomic Force Microscopy (AFM) to visualize the keratinocytes intercellular structure. The AFM based nanomanipulation system is employed to perform the nanoindentation experiment for measuring keratinocytes nanomechanical property under both physiological and pathophysiological conditions. Our demonstration of the use of AFM for in situ imaging and nanomanipulation for quantifying stiffness in nanoscale can facilitate the investigation of diseases related to blistering and development of therapeutic strategies accordingly. © 2009 IEEE NANO Organizers.
Persistent Identifierhttp://hdl.handle.net/10722/213103

 

DC FieldValueLanguage
dc.contributor.authorYang, Ruiguo-
dc.contributor.authorXi, Ning-
dc.contributor.authorKar, Carmen-
dc.contributor.authorFung, Man-
dc.contributor.authorWai, King-
dc.contributor.authorLai, Chiu-
dc.contributor.authorSeiffert-Sinha, Kristina-
dc.contributor.authorSinha, Amnish A.-
dc.date.accessioned2015-07-28T04:06:08Z-
dc.date.available2015-07-28T04:06:08Z-
dc.date.issued2009-
dc.identifier.citation2009 9th IEEE Conference on Nanotechnology, IEEE NANO 2009, 2009, p. 640-643-
dc.identifier.urihttp://hdl.handle.net/10722/213103-
dc.description.abstractDesmosomes are cell-cell junctions that provide mechanical strength for cells and maintain integrity of tissues in animal skins and hearts. Disruption of the desmosome like in some autoimmune diseases will therefore change the mechanical property of the anchoring cells and causing blistering. In the paper, we used Atomic Force Microscopy (AFM) to visualize the keratinocytes intercellular structure. The AFM based nanomanipulation system is employed to perform the nanoindentation experiment for measuring keratinocytes nanomechanical property under both physiological and pathophysiological conditions. Our demonstration of the use of AFM for in situ imaging and nanomanipulation for quantifying stiffness in nanoscale can facilitate the investigation of diseases related to blistering and development of therapeutic strategies accordingly. © 2009 IEEE NANO Organizers.-
dc.languageeng-
dc.relation.ispartof2009 9th IEEE Conference on Nanotechnology, IEEE NANO 2009-
dc.subjectAFM-
dc.subjectCell stiffness-
dc.subjectNanomanipulation-
dc.subjectDesmosome-
dc.titleAnalysis of keratinocytes stiffness after desmosome disruption using Atomic Force Microscopy based nanomanipulation-
dc.typeConference_Paper-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-77951009253-
dc.identifier.spage640-
dc.identifier.epage643-

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