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Article: Quantitative mechanical evaluation and analysis of Drosophila embryos through the stages of embryogenesis

TitleQuantitative mechanical evaluation and analysis of Drosophila embryos through the stages of embryogenesis
Authors
KeywordsYoung's modulus
Stiffness
Quantitative evaluation
Microinjection
Microforce
Mechanical impedance
Fruit fly Drosophila embryo
Embryogenesis stages
Issue Date2008
Citation
Birth Defects Research Part C - Embryo Today: Reviews, 2008, v. 84, n. 3, p. 204-214 How to Cite?
AbstractThe fruit fly Drosophila embryo is one of the most important model organisms in genetics and developmental biology research. To better understand the biomechanical properties involved in Drosophila embryo research, this work presents a mechanical characterization of living Drosophila embryos through the stages of embryogenesis. Measurements of the mechanical forces of Drosophila embryos are implemented using a novel, in situ, and minimally invasive force sensing tool with a resolution in the range of μN. The measurements offer an essential understanding of penetration force profiles during the microinjection of Drosophila embryos. Sequentially quantitative evaluation and analysis of the mechanical properties, such as Young's modulus, stiffness, and mechanical impedance of living Drosophila embryos are performed by extracting the force measurements throughout the stages of embryogenesis. Experimental results illustrate the changing mechanical properties of Drosophila embryos during development, and thus mathematical models are proposed. The evaluation provides a critical step toward better understanding of the biomechanical properties of Drosophila embryos during embryogenesis, and could contribute to more efficient and significant genetic and embryonic development research on Drosophila. © 2008 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/213006
ISSN
2015 Impact Factor: 3.12
2015 SCImago Journal Rankings: 1.513

 

DC FieldValueLanguage
dc.contributor.authorShen, Yantao-
dc.contributor.authorZhang, Rui-
dc.contributor.authorCozen, Scott-
dc.contributor.authorXi, Ning-
dc.contributor.authorWejinya, Uchechukwa C.-
dc.contributor.authorHao, Lina-
dc.date.accessioned2015-07-28T04:05:44Z-
dc.date.available2015-07-28T04:05:44Z-
dc.date.issued2008-
dc.identifier.citationBirth Defects Research Part C - Embryo Today: Reviews, 2008, v. 84, n. 3, p. 204-214-
dc.identifier.issn1542-975X-
dc.identifier.urihttp://hdl.handle.net/10722/213006-
dc.description.abstractThe fruit fly Drosophila embryo is one of the most important model organisms in genetics and developmental biology research. To better understand the biomechanical properties involved in Drosophila embryo research, this work presents a mechanical characterization of living Drosophila embryos through the stages of embryogenesis. Measurements of the mechanical forces of Drosophila embryos are implemented using a novel, in situ, and minimally invasive force sensing tool with a resolution in the range of μN. The measurements offer an essential understanding of penetration force profiles during the microinjection of Drosophila embryos. Sequentially quantitative evaluation and analysis of the mechanical properties, such as Young's modulus, stiffness, and mechanical impedance of living Drosophila embryos are performed by extracting the force measurements throughout the stages of embryogenesis. Experimental results illustrate the changing mechanical properties of Drosophila embryos during development, and thus mathematical models are proposed. The evaluation provides a critical step toward better understanding of the biomechanical properties of Drosophila embryos during embryogenesis, and could contribute to more efficient and significant genetic and embryonic development research on Drosophila. © 2008 Wiley-Liss, Inc.-
dc.languageeng-
dc.relation.ispartofBirth Defects Research Part C - Embryo Today: Reviews-
dc.subjectYoung's modulus-
dc.subjectStiffness-
dc.subjectQuantitative evaluation-
dc.subjectMicroinjection-
dc.subjectMicroforce-
dc.subjectMechanical impedance-
dc.subjectFruit fly Drosophila embryo-
dc.subjectEmbryogenesis stages-
dc.titleQuantitative mechanical evaluation and analysis of Drosophila embryos through the stages of embryogenesis-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1002/bdrc.20131-
dc.identifier.pmid18773458-
dc.identifier.scopuseid_2-s2.0-51949095283-
dc.identifier.volume84-
dc.identifier.issue3-
dc.identifier.spage204-
dc.identifier.epage214-

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