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Article: Investigation of angiotensin II type 1 receptor by atomic force microscopy with functionalized tip

TitleInvestigation of angiotensin II type 1 receptor by atomic force microscopy with functionalized tip
Authors
KeywordsAtomic force microscopy
Single-molecule recognition
Tip functionalization
Angiotensin II type 1 receptor
Issue Date2005
Citation
Nanomedicine: Nanotechnology, Biology, and Medicine, 2005, v. 1, n. 4, p. 306-312 How to Cite?
AbstractAlthough membrane proteins consist of a substantial amount of the human genome and are the main drug targets, the study of cell membrane proteins in situ is complicated by the technical limitations. The recent development of atomic force microscopy (AFM) opens a new way to study the functions of cell membrane proteins in situ at the single-molecule level. A detailed procedure for investigation of angiotensin II type 1 receptor by AFM with functionalized tip is introduced in this article. Some prospective methods to improve the imaging resolution are also discussed. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/212862
ISSN
2015 Impact Factor: 5.671
2015 SCImago Journal Rankings: 1.886

 

DC FieldValueLanguage
dc.contributor.authorLi, Guangyong-
dc.contributor.authorXi, Ning-
dc.contributor.authorWang, Donna H.-
dc.date.accessioned2015-07-28T04:05:15Z-
dc.date.available2015-07-28T04:05:15Z-
dc.date.issued2005-
dc.identifier.citationNanomedicine: Nanotechnology, Biology, and Medicine, 2005, v. 1, n. 4, p. 306-312-
dc.identifier.issn1549-9634-
dc.identifier.urihttp://hdl.handle.net/10722/212862-
dc.description.abstractAlthough membrane proteins consist of a substantial amount of the human genome and are the main drug targets, the study of cell membrane proteins in situ is complicated by the technical limitations. The recent development of atomic force microscopy (AFM) opens a new way to study the functions of cell membrane proteins in situ at the single-molecule level. A detailed procedure for investigation of angiotensin II type 1 receptor by AFM with functionalized tip is introduced in this article. Some prospective methods to improve the imaging resolution are also discussed. © 2005 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofNanomedicine: Nanotechnology, Biology, and Medicine-
dc.subjectAtomic force microscopy-
dc.subjectSingle-molecule recognition-
dc.subjectTip functionalization-
dc.subjectAngiotensin II type 1 receptor-
dc.titleInvestigation of angiotensin II type 1 receptor by atomic force microscopy with functionalized tip-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.nano.2005.10.004-
dc.identifier.pmid17292103-
dc.identifier.scopuseid_2-s2.0-33645663597-
dc.identifier.volume1-
dc.identifier.issue4-
dc.identifier.spage306-
dc.identifier.epage312-

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