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Article: Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis

TitleCorrelation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis
Authors
Issue Date2013
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cdi/
Citation
Clinical & Developmental Immunology, 2013, v. 2013, article no. 345347 How to Cite?
AbstractIt was reported that IL-17 had been detected in the inflammatory infiltrates of patients with DM (dermatomyositis). In this study, we investigated the frequency of Th17 cells and the expression of microRNA-206 (miR-206) in DM patients. Firstly, we observed that the frequency of Th17 cells and the expression of transcription factors were increased significantly in the PBMCs of DM patients. Secondly, we found that there was a positive correlation between the percentages of Th17 cells and serum level of CK in DM patients. And the serum concentrations of IL-6, IL-1β, TGF-β, and IL-23, the important cytokines of Th17 differentiation, were increased in DM patients. It was predicted that Krüppel-like factor 4 (KLF4) is one of the multiple targets of miR-206. We detected the expression of miR-206 in DM patients, and it was decreased in the serum and PBMCs of DM patients. The augmented expression of KLF is accompanied by the attenuated expression of miR-206. Furthermore, a negative correlation between the percentages of Th17 cells and the expression of miR-206 in DM patients has been found. Taken together, these findings suggest the attenuated expression of miR-206, and the augmented frequency of Th17 cells in DM patients.
Persistent Identifierhttp://hdl.handle.net/10722/212115
ISSN
2015 Impact Factor: 3.603
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorTang, X-
dc.contributor.authorTian, X-
dc.contributor.authorZhang, Y-
dc.contributor.authorWu, W-
dc.contributor.authorTian, J-
dc.contributor.authorRui, K-
dc.contributor.authorTong, J-
dc.contributor.authorLu, L-
dc.contributor.authorXu, H-
dc.contributor.authorWang, S-
dc.date.accessioned2015-07-21T02:23:31Z-
dc.date.available2015-07-21T02:23:31Z-
dc.date.issued2013-
dc.identifier.citationClinical & Developmental Immunology, 2013, v. 2013, article no. 345347-
dc.identifier.issn1740-2522-
dc.identifier.urihttp://hdl.handle.net/10722/212115-
dc.description.abstractIt was reported that IL-17 had been detected in the inflammatory infiltrates of patients with DM (dermatomyositis). In this study, we investigated the frequency of Th17 cells and the expression of microRNA-206 (miR-206) in DM patients. Firstly, we observed that the frequency of Th17 cells and the expression of transcription factors were increased significantly in the PBMCs of DM patients. Secondly, we found that there was a positive correlation between the percentages of Th17 cells and serum level of CK in DM patients. And the serum concentrations of IL-6, IL-1β, TGF-β, and IL-23, the important cytokines of Th17 differentiation, were increased in DM patients. It was predicted that Krüppel-like factor 4 (KLF4) is one of the multiple targets of miR-206. We detected the expression of miR-206 in DM patients, and it was decreased in the serum and PBMCs of DM patients. The augmented expression of KLF is accompanied by the attenuated expression of miR-206. Furthermore, a negative correlation between the percentages of Th17 cells and the expression of miR-206 in DM patients has been found. Taken together, these findings suggest the attenuated expression of miR-206, and the augmented frequency of Th17 cells in DM patients.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cdi/-
dc.relation.ispartofClinical & Developmental Immunology-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleCorrelation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis-
dc.typeArticle-
dc.identifier.emailLu, L: liweilu@hkucc.hku.hk-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2013/345347-
dc.identifier.pmid24288551-
dc.identifier.pmcidPMC3830811-
dc.identifier.hkuros244998-
dc.identifier.volume2013-
dc.publisher.placeUnited States-

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