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Article: Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease

TitleMiddle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease
Authors
Issue Date2015
PublisherAmerican Society for Microbiology.
Citation
Clinical Microbiology Reviews, 2015, v. 28 n. 2, p. 465-522 How to Cite?
AbstractThe source of the severe acute respiratory syndrome (SARS) epidemic was traced to wildlife market civets and ultimately to bats. Subsequent hunting for novel coronaviruses (CoVs) led to the discovery of two additional human and over 40 animal CoVs, including the prototype lineage C betacoronaviruses, Tylonycteris bat CoV HKU4 and Pipistrellus bat CoV HKU5; these are phylogenetically closely related to the Middle East respiratory syndrome (MERS) CoV, which has affected more than 1,000 patients with over 35% fatality since its emergence in 2012. All primary cases of MERS are epidemiologically linked to the Middle East. Some of these patients had contacted camels which shed virus and/or had positive serology. Most secondary cases are related to health care-associated clusters. The disease is especially severe in elderly men with comorbidities. Clinical severity may be related to MERS-CoV's ability to infect a broad range of cells with DPP4 expression, evade the host innate immune response, and induce cytokine dysregulation. Reverse transcription-PCR on respiratory and/or extrapulmonary specimens rapidly establishes diagnosis. Supportive treatment with extracorporeal membrane oxygenation and dialysis is often required in patients with organ failure. Antivirals with potent in vitro activities include neutralizing monoclonal antibodies, antiviral peptides, interferons, mycophenolic acid, and lopinavir. They should be evaluated in suitable animal models before clinical trials. Developing an effective camel MERS-CoV vaccine and implementing appropriate infection control measures may control the continuing epidemic. © 2015, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/211848
ISSN
2015 Impact Factor: 16.187
2015 SCImago Journal Rankings: 8.741
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, JFW-
dc.contributor.authorLau, SKP-
dc.contributor.authorTo, KKW-
dc.contributor.authorCheng, VCC-
dc.contributor.authorWoo, PCY-
dc.contributor.authorYuen, KY-
dc.date.accessioned2015-07-21T02:13:24Z-
dc.date.available2015-07-21T02:13:24Z-
dc.date.issued2015-
dc.identifier.citationClinical Microbiology Reviews, 2015, v. 28 n. 2, p. 465-522-
dc.identifier.issn0893-8512-
dc.identifier.urihttp://hdl.handle.net/10722/211848-
dc.description.abstractThe source of the severe acute respiratory syndrome (SARS) epidemic was traced to wildlife market civets and ultimately to bats. Subsequent hunting for novel coronaviruses (CoVs) led to the discovery of two additional human and over 40 animal CoVs, including the prototype lineage C betacoronaviruses, Tylonycteris bat CoV HKU4 and Pipistrellus bat CoV HKU5; these are phylogenetically closely related to the Middle East respiratory syndrome (MERS) CoV, which has affected more than 1,000 patients with over 35% fatality since its emergence in 2012. All primary cases of MERS are epidemiologically linked to the Middle East. Some of these patients had contacted camels which shed virus and/or had positive serology. Most secondary cases are related to health care-associated clusters. The disease is especially severe in elderly men with comorbidities. Clinical severity may be related to MERS-CoV's ability to infect a broad range of cells with DPP4 expression, evade the host innate immune response, and induce cytokine dysregulation. Reverse transcription-PCR on respiratory and/or extrapulmonary specimens rapidly establishes diagnosis. Supportive treatment with extracorporeal membrane oxygenation and dialysis is often required in patients with organ failure. Antivirals with potent in vitro activities include neutralizing monoclonal antibodies, antiviral peptides, interferons, mycophenolic acid, and lopinavir. They should be evaluated in suitable animal models before clinical trials. Developing an effective camel MERS-CoV vaccine and implementing appropriate infection control measures may control the continuing epidemic. © 2015, American Society for Microbiology. All Rights Reserved.-
dc.languageeng-
dc.publisherAmerican Society for Microbiology.-
dc.relation.ispartofClinical Microbiology Reviews-
dc.rightsClinical Microbiology Reviews. Copyright © American Society for Microbiology.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleMiddle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease-
dc.typeArticle-
dc.identifier.emailChan, JFW: jfwchan@hku.hk-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hk-
dc.identifier.emailCheng, VCC: vcccheng@hkucc.hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityChan, JFW=rp01736-
dc.identifier.authorityLau, SKP=rp00486-
dc.identifier.authorityTo, KKW=rp01384-
dc.identifier.authorityWoo, PCY=rp00430-
dc.identifier.authorityYuen, KY=rp00366-
dc.description.naturepostprint-
dc.identifier.doi10.1128/CMR.00102-14-
dc.identifier.pmid25810418-
dc.identifier.scopuseid_2-s2.0-84959851955-
dc.identifier.hkuros245619-
dc.identifier.volume28-
dc.identifier.issue2-
dc.identifier.spage465-
dc.identifier.epage522-
dc.identifier.isiWOS:000356359400007-
dc.publisher.placeUnited States-

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