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Conference Paper: An immunohistochemical comparison of ovarian and uterine endometrioid carcinoma, endometrioid carcinoma with clear cell change and clear cell carcinoma

TitleAn immunohistochemical comparison of ovarian and uterine endometrioid carcinoma, endometrioid carcinoma with clear cell change and clear cell carcinoma
Authors
KeywordsMedical sciences biology
Issue Date2014
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/
Citation
The 103rd Annual Meeting of the United States and Canadian Academy of Pathology (USCAP 2014), San Diego, CA., 1-7 March 2014. In Modern Pathology, 2014, v. 27 suppl. 2, p. 293A, abstract no. 1211 How to Cite?
AbstractBACKGROUND: Endometrioid and clear cell carcinomas(CCC) of the gynecological tract show distinct clinicopathological profi les. Occasionally, endometrioid carcinomas(EC) exhibit clear cell change, mimicking CCC. This study compares the immunoprofi les of ovarian and uterine EC, EC with clear cell change(EC-CC) and CCC. DESIGN: Representative sections were selected from 62 CCC(38 ovarian, 24 uterine), 33 FIGO grade 1-2 EC(22 ovarian, 11 uterine) and 33 EC-CC(5 ovarian, 28 uterine) and stained for HNF1β, BAF250a(ARID1a), NapsinA, ER and PR. EC-CC slides showed≥10% CC areas, comprising either of squamoid, secretory or non-specifi c(NOS) change. Intensity of staining was scored as 0 to 3+ and extent of staining was scored as: 1+=<1%; 2+=≥1%to<10%; 3+=≥10%to<50% and 4+=≥50%. Any nuclear or cytoplasmic staining was considered positive for (HNF1β, ER and PR) and NapsinA respectively. Loss of BAF250a was defi ned as lack of nuclear staining in >90% of cells. RESULTS: 55/62(88.7%)CCC, 14/33(42.4%)EC-CC and 17/33(51.5%)EC showed immunoreactivity for HNF1 β and staining was≥2+ in≥10% of cells in 49/55, 10/14 and 9/17 cases, respectively. 54/62(87.1%)CCC, 4/33(12.1%)EC-CC and 2/33(6.1%) EC stained for NapsinA. 49/54CCC and 2/4uterine-EC-CC (both with NOS CC) demonstrated≥2+ staining in≥10% of cells. Staining was 3+ in <1% of cells in 2 EC(ovarian). 11/62(17.7%)CCC, 4/33(12.1%)EC-CC and 2/33(6.1%)EC showed loss of BAF250a. Four EC-CC(uterine) showed decreased expression of BAF250a in CC areas (2 secretory and 2 NOS changes). ER was expressed in 10/62(16.1%)CCC, 29/33(87.9%)EC-CC and 31/33(93.9%)EC, while PR was positive in 9/62(14.5%) CCC, 25/33(75.8%)EC-CC and 32/33(97.0%)EC. Decreased ER and PR expression was identifi ed in CC areas of 13/24(54.2%) and 6/21 (28.6%) uterine EC-CC as well as 4/5(80%) and 2/4(50%) ovarian EC-CC. Differences in immunoexpression of HNF1β, NapsinA, ER and PR in CCC versus EC-CC/EC were statistically signifi cant(p<0.0001). EC-CC showed a statistically signifi cant reduced PR positivity when compared to EC(p=0.0268). Although EC-CC also demonstrated a trend towards loss of BAF250a and ER, the difference in expression between EC-CC versus EC was not statistically signifi cant(p=0.67). CONCLUSIONS: EC-CC and EC show similar immunoprofi les. Use of HNF1β, NapsinA, ER and PR can help distinguish EC-CC from CCC.
DescriptionSession - Gynecologic and Obstetric Pathology: no. 1211
This free journal suppl. contain abstracts of USCAP 2014 Annual Meeting
Persistent Identifierhttp://hdl.handle.net/10722/211473
ISSN
2015 Impact Factor: 5.485
2015 SCImago Journal Rankings: 2.803

 

DC FieldValueLanguage
dc.contributor.authorLim, D-
dc.contributor.authorIp, P-
dc.contributor.authorCheung, A-
dc.contributor.authorKiyokawa, T-
dc.contributor.authorOliva, E-
dc.date.accessioned2015-07-15T03:23:54Z-
dc.date.available2015-07-15T03:23:54Z-
dc.date.issued2014-
dc.identifier.citationThe 103rd Annual Meeting of the United States and Canadian Academy of Pathology (USCAP 2014), San Diego, CA., 1-7 March 2014. In Modern Pathology, 2014, v. 27 suppl. 2, p. 293A, abstract no. 1211-
dc.identifier.issn0893-3952-
dc.identifier.urihttp://hdl.handle.net/10722/211473-
dc.descriptionSession - Gynecologic and Obstetric Pathology: no. 1211-
dc.descriptionThis free journal suppl. contain abstracts of USCAP 2014 Annual Meeting-
dc.description.abstractBACKGROUND: Endometrioid and clear cell carcinomas(CCC) of the gynecological tract show distinct clinicopathological profi les. Occasionally, endometrioid carcinomas(EC) exhibit clear cell change, mimicking CCC. This study compares the immunoprofi les of ovarian and uterine EC, EC with clear cell change(EC-CC) and CCC. DESIGN: Representative sections were selected from 62 CCC(38 ovarian, 24 uterine), 33 FIGO grade 1-2 EC(22 ovarian, 11 uterine) and 33 EC-CC(5 ovarian, 28 uterine) and stained for HNF1β, BAF250a(ARID1a), NapsinA, ER and PR. EC-CC slides showed≥10% CC areas, comprising either of squamoid, secretory or non-specifi c(NOS) change. Intensity of staining was scored as 0 to 3+ and extent of staining was scored as: 1+=<1%; 2+=≥1%to<10%; 3+=≥10%to<50% and 4+=≥50%. Any nuclear or cytoplasmic staining was considered positive for (HNF1β, ER and PR) and NapsinA respectively. Loss of BAF250a was defi ned as lack of nuclear staining in >90% of cells. RESULTS: 55/62(88.7%)CCC, 14/33(42.4%)EC-CC and 17/33(51.5%)EC showed immunoreactivity for HNF1 β and staining was≥2+ in≥10% of cells in 49/55, 10/14 and 9/17 cases, respectively. 54/62(87.1%)CCC, 4/33(12.1%)EC-CC and 2/33(6.1%) EC stained for NapsinA. 49/54CCC and 2/4uterine-EC-CC (both with NOS CC) demonstrated≥2+ staining in≥10% of cells. Staining was 3+ in <1% of cells in 2 EC(ovarian). 11/62(17.7%)CCC, 4/33(12.1%)EC-CC and 2/33(6.1%)EC showed loss of BAF250a. Four EC-CC(uterine) showed decreased expression of BAF250a in CC areas (2 secretory and 2 NOS changes). ER was expressed in 10/62(16.1%)CCC, 29/33(87.9%)EC-CC and 31/33(93.9%)EC, while PR was positive in 9/62(14.5%) CCC, 25/33(75.8%)EC-CC and 32/33(97.0%)EC. Decreased ER and PR expression was identifi ed in CC areas of 13/24(54.2%) and 6/21 (28.6%) uterine EC-CC as well as 4/5(80%) and 2/4(50%) ovarian EC-CC. Differences in immunoexpression of HNF1β, NapsinA, ER and PR in CCC versus EC-CC/EC were statistically signifi cant(p<0.0001). EC-CC showed a statistically signifi cant reduced PR positivity when compared to EC(p=0.0268). Although EC-CC also demonstrated a trend towards loss of BAF250a and ER, the difference in expression between EC-CC versus EC was not statistically signifi cant(p=0.67). CONCLUSIONS: EC-CC and EC show similar immunoprofi les. Use of HNF1β, NapsinA, ER and PR can help distinguish EC-CC from CCC.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/-
dc.relation.ispartofModern Pathology-
dc.subjectMedical sciences biology-
dc.titleAn immunohistochemical comparison of ovarian and uterine endometrioid carcinoma, endometrioid carcinoma with clear cell change and clear cell carcinoma-
dc.typeConference_Paper-
dc.identifier.emailIp, P: philipip@hku.hk-
dc.identifier.emailCheung, A: anycheun@hkucc.hku.hk-
dc.identifier.authorityIp, P=rp01890-
dc.identifier.authorityCheung, A=rp00542-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/modpathol.2014.15-
dc.identifier.hkuros244967-
dc.identifier.volume27-
dc.identifier.issuesuppl. 2-
dc.identifier.spage293A, abstract no. 1211-
dc.identifier.epage293A, abstract no. 1211-
dc.publisher.placeUnited Kingdom-

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