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Article: MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma

TitleMicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma
Authors
Issue Date2014
PublisherImpact Journals LLC. The Journal's web site is located at http://www.impactjournals.com/oncotarget/index.html
Citation
Oncotarget, 2014, v. 5 n. 22, p. 11669-11680 How to Cite?
AbstractMicroRNAs (miRNAs) play a critical role in development and progression of cancers. Deregulation of MicroRNA-9 (miR-9) has been documented in many types of cancers but their role in the development of esophageal squamous cell carcinoma (ESCC) has not been studied. This study aimed to investigate the effect of miR-9 in esophageal cancer metastasis. The up-regulation of miR-9 was frequently detected in primary ESCC tumor tissue, which was significantly associated with clinical progression (P = 0.022), lymph node metastasis (P = 0.007) and poor overall survival (P < 0.001). Functional study demonstrated that miR-9 promoted cell migration and tumor metastasis, which were effectively inhibited when expression of miR-9 was silenced. Moreover, we demonstrated that miR-9 interacted with the 3'-untranslated region of E-cadherin and down-regulated its expression, which induced beta-catenin nuclear translocation and subsequently up-regulated c-myc and CD44 expression. In addition, miR-9 induced epithelial-mesenchymal transition (EMT) in ESCC, a key event in tumor metastasis. Taken together, our study demonstrates that miR-9 plays an important role in ESCC metastasis by activating beta-catenin pathway and inducing EMT via targeting E-cadherin. Our study also suggests miR-9 can be served as a new independent prognostic marker and/or as a novel potential therapeutic target for ESCC.
Persistent Identifierhttp://hdl.handle.net/10722/210716
ISSN
2015 Impact Factor: 5.008
2015 SCImago Journal Rankings: 2.294
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSong, Y-
dc.contributor.authorLI, J-
dc.contributor.authorZhu, Y-
dc.contributor.authorDai, Y-
dc.contributor.authorZeng, T-
dc.contributor.authorLiu, L-
dc.contributor.authorLi, J-
dc.contributor.authorWang, H-
dc.contributor.authorQin, Y-
dc.contributor.authorZeng, M-
dc.contributor.authorGuan, X-
dc.contributor.authorLi, Y-
dc.date.accessioned2015-06-23T05:48:14Z-
dc.date.available2015-06-23T05:48:14Z-
dc.date.issued2014-
dc.identifier.citationOncotarget, 2014, v. 5 n. 22, p. 11669-11680-
dc.identifier.issn1949-2553-
dc.identifier.urihttp://hdl.handle.net/10722/210716-
dc.description.abstractMicroRNAs (miRNAs) play a critical role in development and progression of cancers. Deregulation of MicroRNA-9 (miR-9) has been documented in many types of cancers but their role in the development of esophageal squamous cell carcinoma (ESCC) has not been studied. This study aimed to investigate the effect of miR-9 in esophageal cancer metastasis. The up-regulation of miR-9 was frequently detected in primary ESCC tumor tissue, which was significantly associated with clinical progression (P = 0.022), lymph node metastasis (P = 0.007) and poor overall survival (P < 0.001). Functional study demonstrated that miR-9 promoted cell migration and tumor metastasis, which were effectively inhibited when expression of miR-9 was silenced. Moreover, we demonstrated that miR-9 interacted with the 3'-untranslated region of E-cadherin and down-regulated its expression, which induced beta-catenin nuclear translocation and subsequently up-regulated c-myc and CD44 expression. In addition, miR-9 induced epithelial-mesenchymal transition (EMT) in ESCC, a key event in tumor metastasis. Taken together, our study demonstrates that miR-9 plays an important role in ESCC metastasis by activating beta-catenin pathway and inducing EMT via targeting E-cadherin. Our study also suggests miR-9 can be served as a new independent prognostic marker and/or as a novel potential therapeutic target for ESCC.-
dc.languageeng-
dc.publisherImpact Journals LLC. The Journal's web site is located at http://www.impactjournals.com/oncotarget/index.html-
dc.relation.ispartofOncotarget-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleMicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma-
dc.typeArticle-
dc.identifier.emailGuan, X: xyguan@hkucc.hku.hk-
dc.identifier.authorityGuan, X=rp00454-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.18632/oncotarget.2581-
dc.identifier.pmid25375090-
dc.identifier.pmcidPMC4294333-
dc.identifier.scopuseid_2-s2.0-84917694835-
dc.identifier.hkuros243540-
dc.identifier.volume5-
dc.identifier.issue22-
dc.identifier.spage11669-
dc.identifier.epage11680-
dc.identifier.isiWOS:000348037400062-
dc.publisher.placeUnited States-

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