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Article: Predisposing factors, microbial characteristics, and clinical outcome of microbial keratitis in a tertiary centre in Hong Kong: a 10-year experience

TitlePredisposing factors, microbial characteristics, and clinical outcome of microbial keratitis in a tertiary centre in Hong Kong: a 10-year experience
Authors
KeywordsMedical sciences
Ophthalmology and optometry
Issue Date2015
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jop
Citation
Journal of Ophthalmology, 2015, v. 2015, article no. 769436, p. 1-10 How to Cite?
AbstractPURPOSE: To study the risk factors, microbial profile, antibiotic susceptibility pattern, and outcome for microbial keratitis over the past 10 years in a tertiary center in Hong Kong. METHODS: All cases with corneal scraping performed in Queen Mary Hospital, Hong Kong from January 2004 to December 2013 were included. Clinical outcome was defined as poor if the final visual acuity (VA) was abnormal or worse than presenting VA, a major complication occurred, or therapeutic keratoplasty was required. RESULTS: 347 scrapes were performed in the 10-year period growing 130 microorganisms (32.3% culture positive rate). Contact lens use was the commonest risk factor. The commonest isolates were coagulase-negative Staphylococcus and Pseudomonas aeruginosa. Fluoroquinolone susceptibility was tested in 47 Gram-negative bacteria with 93.6% susceptibility (100% for Pseudomonas). 90.7% of cases had good visual outcome.Multivariate logistic regression showed age (𝑝 = 0.03), trauma (𝑝 = 0.006), and ulcer size >3mm (𝑝 = 0.039) to be independently associated with poor outcome. CONCLUSION: There was no shifting trend in the isolate distribution or emergence of resistant strains in our study. Contact lens wear was the commonest risk factor, with Pseudomonas being the most frequent isolate in this group. It remained 100% susceptible to fluoroquinolones and 97% cases had good visual outcome. © Hindawi Publishing Corporation.
Persistent Identifierhttp://hdl.handle.net/10722/210652
ISSN
2015 Impact Factor: 1.463
2015 SCImago Journal Rankings: 0.870
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, ALK-
dc.contributor.authorTo, KKW-
dc.contributor.authorChoi, CCL-
dc.contributor.authorYuen, LH-
dc.contributor.authorYim, SM-
dc.contributor.authorChan, KSK-
dc.contributor.authorLai, JSM-
dc.contributor.authorWong, IYH-
dc.date.accessioned2015-06-23T01:53:16Z-
dc.date.available2015-06-23T01:53:16Z-
dc.date.issued2015-
dc.identifier.citationJournal of Ophthalmology, 2015, v. 2015, article no. 769436, p. 1-10-
dc.identifier.issn2090-004X-
dc.identifier.urihttp://hdl.handle.net/10722/210652-
dc.description.abstractPURPOSE: To study the risk factors, microbial profile, antibiotic susceptibility pattern, and outcome for microbial keratitis over the past 10 years in a tertiary center in Hong Kong. METHODS: All cases with corneal scraping performed in Queen Mary Hospital, Hong Kong from January 2004 to December 2013 were included. Clinical outcome was defined as poor if the final visual acuity (VA) was abnormal or worse than presenting VA, a major complication occurred, or therapeutic keratoplasty was required. RESULTS: 347 scrapes were performed in the 10-year period growing 130 microorganisms (32.3% culture positive rate). Contact lens use was the commonest risk factor. The commonest isolates were coagulase-negative Staphylococcus and Pseudomonas aeruginosa. Fluoroquinolone susceptibility was tested in 47 Gram-negative bacteria with 93.6% susceptibility (100% for Pseudomonas). 90.7% of cases had good visual outcome.Multivariate logistic regression showed age (𝑝 = 0.03), trauma (𝑝 = 0.006), and ulcer size >3mm (𝑝 = 0.039) to be independently associated with poor outcome. CONCLUSION: There was no shifting trend in the isolate distribution or emergence of resistant strains in our study. Contact lens wear was the commonest risk factor, with Pseudomonas being the most frequent isolate in this group. It remained 100% susceptible to fluoroquinolones and 97% cases had good visual outcome. © Hindawi Publishing Corporation.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jop-
dc.relation.ispartofJournal of Ophthalmology-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciences-
dc.subjectOphthalmology and optometry-
dc.titlePredisposing factors, microbial characteristics, and clinical outcome of microbial keratitis in a tertiary centre in Hong Kong: a 10-year experience-
dc.typeArticle-
dc.identifier.emailNg, ALK: nlk008@hku.hk-
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hk-
dc.identifier.emailYuen, LH: lhyuen@hku.hk-
dc.identifier.emailYim, SM: smyim@hkucc.hku.hk-
dc.identifier.emailChan, KSK: keith1@hkucc.hku.hk-
dc.identifier.emailLai, JSM: laism@hku.hk-
dc.identifier.emailWong, IYH: wongyhi@hku.hk-
dc.identifier.authorityNg, ALK=rp01842-
dc.identifier.authorityTo, KKW=rp01384-
dc.identifier.authorityLai, JSM=rp00295-
dc.identifier.authorityWong, IYH=rp01467-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2015/769436-
dc.identifier.pmid26167295-
dc.identifier.pmcidPMC4488544-
dc.identifier.scopuseid_2-s2.0-84934324355-
dc.identifier.hkuros244255-
dc.identifier.volume2015-
dc.identifier.spage1-
dc.identifier.epage10-
dc.identifier.isiWOS:000357214500001-
dc.publisher.placeUnited States-

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